Search results for "TEP"
showing 10 items of 712 documents
Experimental and theoretical evidence for bilayer-by-bilayer surface melting of crystalline ice
2017
On the surface of water ice, a quasi-liquid layer (QLL) has been extensively reported at temperatures below its bulk melting point at 273 K. Approaching the bulk melting temperature from below, the thickness of the QLL is known to increase. To elucidate the precise temperature variation of the QLL, and its nature, we investigate the surface melting of hexagonal ice by combining noncontact, surface-specific vibrational sum frequency generation (SFG) spectroscopy and spectra calculated from molecular dynamics simulations. Using SFG, we probe the outermost water layers of distinct single crystalline ice faces at different temperatures. For the basal face, a stepwise, sudden weakening of the hy…
In vivo efficacy of verteporfin loaded gold nanorods for combined photothermal/photodynamic colon cancer therapy.
2022
The high incidence of cancer recurrences and the frequent occurrence of multidrug resistance often stem from a poorly selective and inefficient antineoplastic therapy, responsible for the onset of undesired side effects as well. A combination of minimal-invasive approaches could thus be a useful strategy to surmount these shortcomings, achieving a safe and solid cancer therapy. Herein, a multi-therapeutic nanotool was designed by merging the photothermal properties of gold nanorods (AuNRs) with the photodynamic activity of the photosensitizer ver-teporfin. AuNRs were coated with the natural materials lipoic acid and gellan gum (AuNRs_LA,GG) and subse-quently loaded with verteporfin (AuNRs_L…
Low effective population sizes and limited connectivity inxerothermic beetles: implications for the conservation ofan endangered habita
2014
Fragmentation and isolation may have detrimental effects on the viability of populations. Xerothermic grasslands, which are extra-zonal analogues of steppes, are among Europe's most endangered natural environments. Information about connectivity between the remaining habitat patches is critical for effective conservation planning. However, very little is known about the actual levels of isolation of individual xerothermic patches at the inter-regional and local scale. In this study, 16 microsatellite loci were used to investigate genetic diversity, structuring, effective sizes (Ne), and connectivity among populations of the weevil Centricnemus leucogrammus at various geographic scales. Anal…
Análisis de la interacciones parásito-hospedador en el modelo Echinostoma caproni-roedor, con énfasis en los factores que determinan el curso de la i…
2015
En la presente Tesis Doctoral se analizan diferentes parámetros implicados en las relaciones parásito-hospedador en helmintiasis intestinales mediante la utilización del modelo experimental Echinostoma caproni-roedor. Con esta finalidad se estudian diversos aspectos inmunológicos, además de las alteraciones intestinales inducidas por la infección en dos sistemas parásito-hospedador: E. caproni-ratón y E. caproni-rata. Los resultados obtenidos ponen de manifiesto que el IFN-γ y el óxido nítrico son mediadores fundamentales en el desarrollo de infecciones crónicas en ratón, induciendo disfunción mitocondrial en las células del epitelio intestinal e hiperplasia tisular. No obstante, se sugiere…
Permeability of the bladder mucosa to thiotepa, adriamycin, and daunomycin in men and rabbits.
1976
The permeability of the bladder mucosa to thiotepa and to the anthraquinonic antibiotics, adriamycin and daunomycin, was investigated both in humans and in experimental animals. Instillations in rabbits were performed either in intact males or in animals with ligated ureters. Absorption of thiotepa was significantly higher than that of the antibiotics both in men and in rabbits. Furthermore, a qualitative difference was observed in rabbits in relation to time and with regard to fixation to vesical tissues. In man, absorption was highest after transurethral surgery. It was also increased in cases with extensive anaplastic tumours or in the presence of acute inflammatory reactions.
Parameters analysis of FitzHugh-Nagumo model for a reliable simulation
2014
International audience; Derived from the pioneer ionic Hodgkin-Huxley model and due to its simplicity and richness from a point view of nonlinear dynamics, the FitzHugh-Nagumo model has been one of the most successful neuron / cardiac cell model. It exists many variations of the original FHN model. Though these FHN type models help to enrich the dynamics of the FHN model. The parameters used in these models are often in biased conditions. The related results would be questionable. So, in this study, the aim is to find the parameter thresholds for one of the commonly used FHN model in order to pride a better simulation environment. The results showed at first that inappropriate time step and…
Non-cooperative game theory based stepwise power tariff model using Monte-Carle simulation for agricultural consumers
2019
Abstract In the present study the concept of non-cooperative game theory is proposed in the retail electricity market for introducing stepwise power tariff model (SPT) for agricultural consumers. The objective of the paper is to increase the energy generation through green energy generation sources (GEGS), introduction of plug-in hybrid electric vehicles, education of families, standard wiring and appliance efficiency in tariffs for agricultural consumers with non-cooperative game theory. Agricultural consumers are able to generate a huge amount of electricity through GEGS and are able to control the consumption in their own way, and the non-cooperative game theory is introduced. Energy con…
Fuzzy Control Strategy for Cooperative Non-holonomic Motion of Cybercars with Passengers Vibration Analysis
2021
The cybercars are electric road wheeled non-holonomic vehicles with fully automated driving capabilities. They contribute to sustainable mobility and are employed as passenger vehicles. Non-holonomic mechanics describes the motion of the cybercar constrained by non-integrable constraints, i.e. constraints on the system velocities that do not arise from constraints on the configuration alone. First of all there are thus with dynamic nonholonomic constraints, i.e. constraints preserved by the basic Euler-Lagrange equations (Bloch, 2000; Melluso, 2007; Raimondi & Melluso, 2006-a). Of course, these constraints are not externally imposed on the system but rather are consequences of the equations…
Generalized differential transform method for nonlinear boundary value problem of fractional order
2015
Abstract In this paper the generalized differential transform method is applied to obtain an approximate solution of linear and nonlinear differential equation of fractional order with boundary conditions. Several numerical examples are considered and comparisons with the existing solution techniques are reported. Results show that the method is effective, easier to implement and very accurate when applied for the solution of fractional boundary values problems.
Step-by-step integration for fractional operators
2018
Abstract In this paper, an approach based on the definition of the Riemann–Liouville fractional operators is proposed in order to provide a different discretisation technique as alternative to the Grunwald–Letnikov operators. The proposed Riemann–Liouville discretisation consists of performing step-by-step integration based upon the discretisation of the function f(t). It has been shown that, as f(t) is discretised as stepwise or piecewise function, the Riemann–Liouville fractional integral and derivative are governing by operators very similar to the Grunwald–Letnikov operators. In order to show the accuracy and capabilities of the proposed Riemann–Liouville discretisation technique and th…