Search results for "TERT"
showing 10 items of 1210 documents
Containment of a Large SARS-CoV-2 Outbreak Among Healthcare Workers in a Pediatric Intensive Care Unit.
2020
Objective Healthcare workers (HCWs) are particularly exposed SARS-CoV-2 because they are critical in preventing viral transmission and treating COVID-19 patients. Within HCWs, personnel of intensive care units (ICUs) are at the forefront of treating patients with a severe course of COVID-19 infection and therefore represent an extremely vulnerable group. Thus, our objective is to contribute to establish means of infection control protecting HCWs in the frontline of the current pandemic. Design An outbreak of SARS-CoV-2 was detected and contained in a pediatric ICU (PICU). The first positive case was identified with a point-of-care diagnostic system on site. Real-time PCR-based testing syste…
Characterization of two Lactococcus lactis zinc membrane proteins, Llmg_0524 and Llmg_0526, and role of Llmg_0524 in cell wall integrity
2015
Background Due to its extraordinary chemical properties, the cysteine amino acid residue is often involved in protein folding, electron driving, sensing stress, and binding metals such as iron or zinc. Lactococcus lactis, a Gram-positive bacterium, houses around one hundred cysteine-rich proteins (with the CX2C motif) in the cytoplasm, but only a few in the membrane. Results In order to understand the role played by this motif we focused our work on two membrane proteins of unknown function: Llmg_0524 and Llmg_0526. Each of these proteins has two CX2C motifs separated by ten amino-acid residues (CX2CX10CX2C). Together with a short intervening gene (llmg_0525), the genes of these two protein…
Evaluation of microbiological screening in a neonatal intensive care unit to optimize empiric antibiotic use.
2019
Impact of systematic whole-body 18F-fluorodeoxyglucose PET/CT on the management of patients suspected of infective endocarditis: the prospective mult…
2021
AbstractBackgroundDiagnostic and patients’ management modifications induced by whole-body 18F-FDG-PET/CT had not been evaluated so far in prosthetic valve (PV) or native valve (NV) infective endocarditis (IE)-suspected patients.MethodsIn sum, 140 consecutive patients in 8 tertiary care hospitals underwent 18F-FDG-PET/CT. ESC-2015-modified Duke criteria and patients’ management plan were established jointly by 2 experts before 18F-FDG-PET/CT. The same experts reestablished Duke classification and patients’ management plan immediately after qualitative interpretation of 18F-FDG-PET/CT. A 6-month final Duke classification was established.ResultsAmong the 70 PV and 70 NV patients, 34 and 46 wer…
Moninkertainen mies : maskuliinisuudet ja kerronta Petri Tammisen teoksissa Elämiä, Miehen ikävä, Väärä asenne ja Piiloutujan maa
2005
Intertextualidad y metaficción en Trazo de tiza de Miguelanxo Prado
2009
Este artículo desarrolla el análisis de la obra Trazo de tiza (Prado, 1993) del ilustrador y autor de cómics Miguelanxo Prado, que obtuvo los premios “Alph-Art al Mejor Álbum Extranjero” en el Festival del Cómic de Angoulême en 1994 y el de “Mejor obra” en el Saló Internacional del Còmic de Barcelona de 1994. En primer lugar se centrará la atención en la explícita red intertextual que la obra plantea: la estructura narrativa de Trazo de tiza surge a partir de una reflexión extraída del cuento de Jorge Luis Borges “Tlön, Uqbar, Orbis Tertius” (Ficciones, 1944). El entramado se completa con otros dos textos: La invención de Morel, novela de Bioy Casares, y Dama de Porto Pim, libro de relatos …
The transnational migration of mindfulness: a call for reflective pause in sport and exercise psychology
2021
Abstract Objectives Research on transnational migration has flourished in recent years, but the transnational movement of ideas, practices, and cultural norms, especially within the sport and exercise psychology community, has received scant attention. We explored the transnational migration of mindfulness to understand how the concept has been culturally adapted to fit the mainstream sport and exercise psychology research and practice. Method Sport-based mindfulness interventions, journal articles in Psychology of Sport and Exercise in 2008–2020, and sessions of the FEPSAC 2019 Congress were examined to reflect on the current positionality of mindfulness within sport and exercise psycholog…
A DYNAMIC PERSPECTIVE ON THE MINOR’S RIGHT TO SELF DETERMINATION: THE LESSON FROM THE CONVENTION ON THE RIGHTS OF THE CHILD (CRC) AND SOME PRACTICAL …
2019
This article aims to investigate the legal status of the minor with particular reference to the profiles of autonomy and determination. Specifically, it analyses the most significant provisions of the Convention on the Rights of the Child (hereinafter CRC) regarding the participation and the role of the minor in the society and the recognition - in terms of legally binding decisions related to his/her life - of his/her decision-taking powers.
Nitric oxide inhibits the ATPase activity of the chaperone-like AAA+ ATPase CDC48, a target for S-nitrosylation in cryptogein signalling in tobacco c…
2012
NO has important physiological functions in plants, including the adaptative response to pathogen attack. We previously demonstrated that cryptogein, an elicitor of defence reaction produced by the oomycete Phytophthora cryptogea , triggers NO synthesis in tobacco. To decipher the role of NO in tobacco cells elicited by cryptogein, in the present study we performed a proteomic approach in order to identify proteins undergoing S-nitrosylation. We provided evidence that cryptogein induced the S-nitrosylation of several proteins and identified 11 candidates, including CDC48 (cell division cycle 48), a member of the AAA+ ATPase (ATPase associated with various cellular activities) family. In vit…
The use of low-resolution phasing followed by phase extension from 7.6 to 2.5 Å resolution with noncrystallographic symmetry to solve the structure o…
2011
P2, the major capsid protein of bacteriophage PM2, adopts the double β-barrel fold characteristic of the PRD1-adenoviral lineage. The 2.5 Å resolution X-ray data obtained by analysis of the two major lattices of a multiple crystal of P2 were phased by molecular replacement, using as a search model structure factors to 7.6 Å resolution obtained from electron density cut from the map of the entire PM2 virion. Phase extension to 2.5 Å resolution used solely sixfold cycling averaging and solvent flattening. This represents an atypical example of an oligomeric protein for which the structure has been determined at high resolution by bootstrapping from low-resolution initial phases.