Search results for "TERT"
showing 10 items of 1210 documents
Análisis de materiales didácticos digitales para guiar y/o apoyar el proceso de enseñanza - aprendizaje de las matemáticas
2018
Las tecnologías digitales han supuesto una revolución en todos los ámbitos de la vida: tecnológico, empresarial, comunicativo, cultural, e incluso en el conocimiento y el entretenimiento. En el panorama educativo tiene también su reflejo y las metodologías y recursos se han redibujado, en cuanto a los diferentes soportes, canales, lenguajes, narrativas,? Estos cambios, sustantivos y profundos, afectan simultáneamente al profesorado, alumnado y familias, pero otros agentes como las administraciones educativas y el sector editorial también se ve involucrado. En esta investigación analizamos una muestra de portales institucionales y plataformas comerciales que ofertan recursos didácticos digit…
Two New Retigerane-Type Sesterterpenoids from the Lichen Leprocaulon microscopicum
2016
International audience; Two new sesterterpenes, 1 and 2, have been isolated from the lichen Leprocaulon microscopicum. In addition to classic chromatographic methods, a liquid-liquid chromatography technique, namely centrifugal partition chromatography (CPC) was applied for the purification of compound 2. The structures were determined by analyses of mass spectrometry and 1D- and 2D-NMR data. The relative configuration of the isolated compounds was assigned on the basis of 2D-NOESY experiments. The two compounds possess a rare pentacyclic carbon skeleton typical for lichen metabolism, and quite unusual in the vegetal kingdom.
Internationalisation process of Spanish banks: strategic orientation after the mergers
2003
The present globalisation of the economy is one of the main forces driving the internationalisation process of firms, a phenomenon that has been one of the most widely studied in the literature and which has given rise to numerous explanatory theories. The manufacturing sectors of machinery, food, textiles, furniture have already consolidated their presence in international markets, induced by the increased competition deriving from liberalisation of foreign trade and the desire to conquer new markets. If in manufacturing sectors globalisation has been high, the service sector has not been far behind. One of the sectors that has been most influenced by changes in the competitive framework i…
Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors.
2014
Outer segments (OS) of rod photoreceptors are cellular compartments specialized in the conversion of light into electrical signals. This process relies on the light-triggered change in the intracellular levels of cyclic guanosine monophosphate (cGMP), which in turn controls the activity of cyclic nucleotide-gated (CNG) channels in the rod OS plasma membrane. The rod CNG channel is a macromolecular complex that in its core harbors the ion-conducting CNGA1 and CNGB1a subunits. To identify additional proteins of the complex that interact with the CNGB1a core subunit we applied affinity purification of mouse retinal proteins followed by mass spectrometry. In combination with in vitro and in viv…
Habitat geometry of benthic substrata: effects on arrival and settlement of mobile epifauna
1996
Abstract The effect of substratum complexity on the early stages of colonization by mobile epifauna was assessed through a comparative study based on the architecture of artificial substrata. We conducted field observations over 4 years, on six types of small plastic substrata placed in the low intertidal zone of an exposed rocky shore, for varied immersion periods (1, 2, 4 and 12 wk). The use of artificial substrata allowed us to manipulate independently structural and spatial features of the habitat, such as total area, amount of folds, intercepting area, total volume, and interstitial volume. The invertebrate fauna colonizing over 300 sample units was recorded, and their densities compar…
Umberto Eco's The Name of the Rose and Intertextuality : Eastern Themes
2020
Abstract The Name of the Rose , first novel by Umberto Eco, the Italian novelist and semiotician was published in 1980. The story happens in the Middle Ages (14th century) in an abbey, having a large and wonderful library. This historical detective story is a complicated novel full of intricate signs and symbols. In this paper, some of the themes of The Name of the Rose found in Eastern texts are discussed that indicate intertextuality and the immense amount of knowledge that Eco had of literature. It is stated that the frame tale is very much similar to Kalila va Demna and some of the subplots of the novel have similarities with stories from ancient Iran and the Middle East. Keywords: The …
Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells.
2014
Abstract Ethnopharmacological relevance The dried rhizome of Coptis chinensis Franch. (family Ranunculaceae ) is traditionally used in Chinese medicine for the treatment of inflammatory diseases and diabetes. Recent studies showed a variety of activities of Coptis chinensis Franch. alkaloids, including neuroprotective, neuroregenerative, anti-diabetic, anti-oxidative and anti-inflammatory effects. However, there is no report on the neuroprotective effect of Coptis chinensis Franch. watery extract against tert -butylhydroperoxide ( t -BOOH) induced oxidative damage. The aim of the study is to investigate neuroprotective properties of Coptis chinensis Franch. rhizome watery extract (CRE) and …
The C-terminal region of the Hot1 transcription factor binds GGGACAAA-related sequences in the promoter of its target genes
2015
Response to hyperosmotic stress in the yeast Saccharomyces cerevisiae involves the participation of the general stress response mediated by Msn2/4 transcription factors and the HOG pathway. One of the transcription factors activated through this pathway is Hot1, which contributes to the control of the expression of several genes involved in glycerol synthesis and flux, or in other functions related to adaptation to adverse conditions. This work provides new data about the interaction mechanism of this transcription factor with DNA. By means of one-hybrid and electrophoretic mobility assays, we demonstrate that the C-terminal region, which corresponds to amino acids 610-719, is the DNA-bindi…
The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans.
2004
After screening a Candida albicans genome data base, the product of an open reading frame (IPF 19760/CA2574) with 41% identity to Saccharomyces cerevisiae vacuolar acid trehalase (Ath1p) was identified and named Atc1p. The deduced amino acid sequence shows that Atc1p contains an N-terminal hydrophobic signal peptide and 20 potential sites for N-glycosylation. C. albicans homozygous mutants that lack acid trehalase activity were constructed by gene disruption at the two ATC chromosomal alleles. Analysis of these null mutants shows that Atc1p is localized in the cell wall and is required for growth on trehalose as a carbon source. An Atc1p endowed with acid trehalase activity was obtained by …
Heart beat rate adaptations to varying salinity of two intertidal Mediterranean bivalves: The invasiveBrachidontes pharaonisand the nativeMytilaster …
2011
Abstract Changes in heart beat rates (HBR) of Brachidontes pharaonis (an invasive Lessepsian species) and Mytilaster minimus (a native Mediterranean species) in response to changes in salinity values from brackish (20) to extreme hyper-saline (75) were investigated both in situ and in the laboratory. The two species displayed different responses to varying salinity, with clear differences in HBR observed between groups investigated at different salinities and between groups originating from different environments. The native species, adapted to narrow salinity changes as those observed in the superficial waters of the Mediterranean Sea, showed signs of stress at salinities slightly above 37…