Search results for "TERT"
showing 10 items of 1210 documents
Preparation and characterization of new low melting ammonium-based ionic liquids with ether functionality
2009
Abstract Eighteen new and three previously known but insufficiently characterized RR´3N+A− and R2R´2N+A− type (R = 2-ethoxyethyl or 4-methoxybenzyl, R´ = methyl, ethyl, n-propyl, n-butyl, n-pentyl or n-hexyl, A = Br, BF4 or PF6) quaternary ammonium (QA) salts were synthesized and characterized by using 1H and 13C NMR techniques, mass spectroscopy and elemental analysis. The bromide salts were synthesized either by treating dimethyl formamide with an ether functionalized alkyl bromide in the presence of potassium carbonate or by treating a tertiary amine with an ether functionalized alkyl bromide. The QA tetrafluoroborates and hexafluorophosphates were synthesized by metathesis reaction betw…
The Procedural Approach to Texts
2016
The intention of this chapter is to show the peculiarities of the point of view of Dressler and de Beaugrande, expressed in their work. The position taken by the two authors in their Introduction is a veiled criticism against van Dijk and Petőfi, which are accused of excessive rigour. Dressler and de Beaugrande’s procedural approach avoids the use of logical bases and they propose a point of view closer to cognitive science. According to Dressler and de Beaugrande, the heart of the procedural approach is semantics. In their view, knowledge and meaning are sensitive to the situation in which they are used. So, the two authors believe that framing the texts and the knowledge about the real wo…
Design e narrazioni
2022
Il testo nasce dall’esigenza di mettere a fuoco le implicazioni cognitive, metodologiche e progettuali del concetto di narrazione, sempre più ricorrente nella nostra esperienza quotidiana soprattutto per le molteplici forme di comunicazione e di produzioni culturali che vi si ispirano; si tratta di un concetto che anche nella riflessione teorica e nella progettualità del design sta alimentando dimensioni fortemente innovative ed evolutive nella costruzione, comunicazione di significati, contenuti immateriali, esperienze e valori emozionali che si sovrappongono e s’intrecciano all’espressione tangibile e funzionale degli oggetti, degli artefatti comunicativi, degli spazi. Si propone un perco…
Total Synthesis of the Glycopeptide Recognition Domain of the P-Selectin Glycoprotein Ligand 1
2008
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun
2003
The AP-1 transcription factor c-Jun is a prototypical nuclear effector of the JNK signal transduction pathway. The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in c-Jun is essential for signal-dependent target gene activation. We show that c-Jun phosphorylation mediates dissociation of an inhibitory complex, which is associated with histone deacetylase 3 (HDAC3). The subsequent events that ultimately cause increased mRNA synthesis are independent of c-Jun phosphorylation and its interaction with JNK. These findings provide an 'activation by de-repression' model as an explanation for the stimulatory function of JNK on c-Jun.
Fantasme et représentation dans l'oeuvre d'Alain Robbe-Grillet
2013
The aim of this Thesis is to examine and interpret the two main notions of Robbe-Grillet’s overall work which are “Fantasy” and “Representation”. This will mainly be demonstrated by the different relationships that are developing between the two concepts and the way they edify the work of the Nouveau Romancier. The fashion in which Robbe-Grillet characterizes fantasy will be the central argument of this Thesis Dissertation, but we will also discuss the idea of representation through the motive of theatre. In fact, the characters of Robbe-Grillet’s movies and books keep on playing stereotypical roles (a spy, a prostitute, a sadist doctor etc…) and the places represented at the beginning of t…
Fluorescence Properties of the Chromophore-Binding Domain of Bacteriophytochrome from Deinococcus radiodurans
2013
Fluorescent proteins are versatile tools for molecular imaging. In this study, we report a detailed analysis of the absorption and fluorescence properties of the chromophore-binding domain from Deinococcus radiodurans and its D207H mutant. Using single photon counting and transient absorption techniques, the average excited state lifetime of both studied systems was about 370 ps. The D207H mutation slightly changed the excited state decay profile but did not have a considerable effect on the average decay time of the system or the shape of the absorption and emission spectra of the biliverdin chromophore. We confirmed that the fluorescence properties of both samples are very similar in vivo…
Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor.
2004
The Trk family of receptor tyrosine kinases and the p75 receptor (p75NTR) mediate the effects of neurotrophins on neuronal survival, differentiation and synaptic plasticity. The neurotrophin BDNF and its cognate receptor tyrosine kinase, TrkB.FL, are highly expressed in neurons of the central nervous system. At later stages in postnatal development the truncated TrkB splice variants (TrkB.T1, TrkB.T2) become abundant. However, the signalling and function of these truncated receptors remained largely elusive.We show that overexpression of TrkB.T1 in hippocampal neurons induces the formation of dendritic filopodia, which are known precursors of synaptic spines. The induction of filopodia by T…
Inhibitory influence of chromogranin A N-terminal fragment (vasostatin-1) on the spontaneous contractions of rat proximal colon
2005
Very little is known about the role played by CGA and its fragments in the gastrointestinal physiology. We have studied the role of CGA N-terminal fragments in the regulation of intestinal smooth muscle contractility by measuring the influence of recombinant CGA 1-78 (VS-1) and synthetic CGA 7-57 peptides on the spontaneous mechanical activity of rat proximal colon in vitro. The mechanical activity was recorded as changes in the intraluminal pressure. VS-1 (0.1-30 nM) and CGA 7-57 (10-300 nM) produced concentration-dependent inhibitory effects, characterized by a progressive decrease in the mean amplitude of circular muscle spontaneous contractions, without affecting the resting tone. The r…