Search results for "TERT"

A Theoretical Study on the Low-Lying Excited States of 2,2′:5′,2′′-Terthiophene and 2,2′:5′,2′′:5′′,2′′′-Quaterthiophene

2005

The nature and properties of the low-lying singlet and triplet valence excited states of 2,2':5',2-terthiophene (terthiophene) and 2,2':5',2:5,2'-quictterthiophene (tetrdthiophene) are discussed on the basis of high-level ab initio. computations. The spectrascopic features determined experimentally for short α-oligothiophenes are rationalised on theoretical grounds. Special attention is devoted to the nonradiative decay process through intersystem crossing (ISC) from the singlet to the triplet manifold, which is known to be relatively less efficient in tetrathiophene. Along the geometry relaxation of the S 1 state of terthiophene, the S' 1 and T 2 states become degenerate, which leads. to a…

Postmodernisma iezīmes Andželas Kārteres stāstu izlasē "Asiņainais kambaris"

2016

Šajā pētījumā aplūkotas postmodernisma iezīmes Andželas Kārteres stāstu izlasē Asiņainais kambaris. Padziļināti tiek apskatīta intertekstualitāte, stilizācija, un fragmentācija, un to izpausmes, lai secinātu kā šīs iezīmes veido postmodernisma stāstu. Šis pētījums izstrādāts veicot ar postmodernisma tēmu saistīto teorētisko materiālu un A.Kārteres stāstu analīzi. Pētījuma aktualitāti ietekmē, pirmkārt, postmodernisma literatūras problemātika – sarežģītā literatūras perioda definīcijas izstrāde, izcelsmes un literārās pēctecības noteikšana. Pētījuma specifiskais fokuss ir aktuāls, jo līdz šim postmodernisma iezīmju izpausmes stāstu izlasē Asiņainais kambaris ir vērtētas, lielākoties, tikai n…

Intertekstuālais aspekts I. Saburovas grāmatā „Par mums”.

2016

Bakalaura darba tēma – “Intertekstuālais aspekts Irinas Saburovas grāmatā “Par mums””. Šī darba mērķis ir intertekstuālā aspekta un interteksta izpēte Irinas Saburovas grāmatā “Par mums”. Šis darbs sastāv no divām daļām. Pirmā, teorētiskā daļa sastāv no vienas nodaļas un piecām apakšnodaļām. Teorētiskajā daļā tiek aplūkots jautājums par intertekstualitāti filoloģiskos pētījumos, intertekstualitātes teorijas rašanās un attīstība, intertekstuālās funkcijas. Tālāk ir intertekstualitātes pazīmju analīze Irinas Saburovas darbos un viņas daiļrades analīze mūsdienu literatūrkritikā. Otrā, praktiskā daļa sastāv no vienas nodaļas un divām apakšnodaļām. Tajā tiek analizēta intertekstualitātes atainoš…

Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressions

2017

A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds were then evaluated for their ability to downregulate the secretion of the VEGF protein and the expression of the VEGF, hTERT, and c-Myc genes; the two latter involved in the activation of telomerase in tumoral cells. Some of the synthetized derivatives showed promising pharmacological features as they exhibited IC50 values in low micromolar range, good therapeutic margins, and a multiple mode of action on tumor cells based on the inhibition of VEGF and, at the same time, of the…

Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tub…

2020

Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3&prime

The rebirth of an image : transformation in the construction of meaning in painting : a case study of Diego Velázquez' and Francis Bacon's papal por…

2006

Trophic structure and functioning of vermetid reef community based on carbon and nitrogen stable isotope analysis.

2009

Membrane topology and post-translational modification of the Saccharomyces cerevisiae essential protein Rot1.

2007

ROT1 is an essential gene that has been related to cell wall biosynthesis, the actin cytoskeleton and protein folding. In order to help to understand its molecular function, we carried out a characterization of the Rot1 protein. It is primarily located at the endoplasmic reticulum-nuclear membrane facing the lumen. Rot1 migrates more slowly than expected, which might suggest post-translational modification. Our results indicate that Rot1 is a protein that is neither GPI-anchored nor O-glycosylated. In contrast, it is N-glycosylated. By a directed mutagenesis of several Asn residues, we identified that the protein is simultaneously glycosylated at N103, N107 and N139. Although the mutation o…

Reading Victory Garden : Competing Interpretations and Loose Ends

2000

A Molecular Dynamics-Shared Pharmacophore Approach to Boost Early-Enrichment Virtual Screening: A Case Study on Peroxisome Proliferator-Activated Rec…

2016

Molecular dynamics (MD) simulations can be used, prior to virtual screening, to add flexibility to proteins and study them in a dynamic way. Furthermore, the use of multiple crystal structures of the same protein containing different co-crystallized ligands can help elucidate the role of the ligand on a protein's active conformation, and then explore the most common interactions between small molecules and the receptor. In this work, we evaluated the contribution of the combined use of MD on crystal structures containing the same protein but different ligands to examine the crucial ligand-protein interactions within the complexes. The study was carried out on peroxisome proliferator-activat…