Search results for "TG"
showing 10 items of 2275 documents
¿Qué habría pintado monet si hubiera sido chino? análisis de recursos pictóricos y gramaticales
2022
El acto de hablar es tan antiguo como el de dibujar, ambos forman parte de las expresiones humanas más instintivas. Para la adquisición del chino como L2 por parte de los hablantes nativos de castellano es conveniente elaborar una estrategia que no radique solo en la explicación gramatical y en ejercicios orales o escritos, es decir, que no debe limitarse a actividades basadas exclusivamente en las lenguas implicadas, la materna y la lengua meta. Como señaló Ciesielkiewitz (2009) 'la lengua nativa parece orientar, e incluso controlar el desarrollo de un nuevo proceso de aprendizaje lingüístico, puesto que el nuevo conocimiento parece someterse a un estricto control o revisión bajo los pará…
A look at ethical issues in action research in education
2015
This reflective contribution covers a wide range of ethical issues which are bound to arise when teacher-researchers engage in technical, practical or critical models of action research. Once these three models are briefly explained, the paper proceeds to justify why ethical dilemmas are an intrinsic part of action research, precisely on account of its collaborative nature and of the diverse motivations, perspectives, and institutional roles held by its participants. As a result, questions around power and control are also likely to arise. Hence, we stress the need for action researchers to anticipate these ethical issues and be prepared to handle them through sincere and respectful dialogu…
Association of ADHD with genetic variants in the 5'-region of the dopamine transporter gene: evidence for allelic heterogeneity.
2008
Contains fulltext : 69953.pdf (Publisher’s version ) (Closed access) Multiple studies have reported an association between attention deficit hyperactivity disorder (ADHD) and the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region (3'UTR) of the dopamine transporter gene (DAT1). Yet, recent meta-analyses of available data find little or no evidence for this association; although there is strong evidence for heterogeneity between datasets. This pattern of findings could arise for several reasons including the presence of relatively rare risk alleles on common haplotype backgrounds or the functional interaction of two or more loci within the g…
Atgremotāju klīniskā materiāla Listeria innocua izolātu ģenētiskais raksturojums
2019
Silva Gradovska (2019): Atgremotāju klīniskā materiāla Listeria innocua izolātu ģenētiskais raksturojums. Listeria ģints baktērijas ir plaši vidē un pārtikas produktos sastopamas baktērijas, no kurām daļa spēj ierosināt listeriozi. Listeria innocua ir Gram-pozitīva vides baktērija, kas ir radniecīga patogēnajai Listeria monocytogenes. Darba mērķis bija raksturot L. innocua izolātus, kas iegūti no atgremotāju klīniskā materiāla un, izmantojot pilna genoma sekvenēšanu, veikt genoma analīzi. Bakalaura darba izstrādes laikā no 70 Listeria innocua atgremotāju klīniskajiem izolātiem, kas ievākti laika periodā no 2012. līdz 2018. gadam, un no kuriem izdalīta DNS, tika sekvenēti ar Illumina MiSeq. …
Retórica forense y ars dictaminis en Lo somni, de Bernat Metge
2014
Resumen: Partiendo de la existencia de un propósito de autodefensa en el origen de Lo somni, y tomando como base la evidente formación retórica y dictaminal de su autor, es posible señalar numerosos elementos que se encuadran dentro del género retórico, concretamente del forense o judicial, y también otros pertenecientes al ars dictaminis, ambos géneros cargados de aspectos formales y a priori difícilmente adaptables a un texto de ficción literaria. Estos rasgos retóricos y dictaminales están tan integrados en el estilo del autor que fluyen de forma completamente natural en el texto, en un bello ejemplo de fusión literaria, jurídica y dictaminal. Palabras clave: autodefensa, retórica, ars d…
J. V. Foix i la ironia romàntica
2016
Resum: L’article es basa en el convenciment que la comprensió usual de la ironia no pot ser aplicada a les obres de J. V. Foix, les quals més aviat han de ser enteses en el context de la ironia romàntica tal com va ser concebuda per Friedrich Schlegel i més tard documentada en la investigació d’Ingrid Strohschneider-Kohrs. Es descriu el terme «reflexió» com l’autonegació de l’absolut per a després analitzar alguns poemes en prosa del poeta, en què tal classe d’ironia pot ser identificada. En els escrits de Foix les freqüents metareflexions sobre poesia o pintura fan aparèixer els textos o els quadres com a il·legibles o dotats d’un gran poder subversiu. Una peça com «El Roc pertús» deconstr…
Systematic Modulation of the Supramolecular Gelation Properties of Bile Acid Alkyl Amides
2018
The self-assembly properties of nine low-molecular-weight gelators (LMWGs) based on bile acid alkyl amides were studied in detail. Based on the results, the number of hydroxyl groups attached to the steroidal backbone plays a major role in the gelation, although the nature of the aliphatic side chain also modulates the gelation abilities. Of the 50 gel systems studied, 35 are based on lithocholic acid and 15 on cholic acid derivatives. The deoxycholic acid derivatives did not form any gels. The gelation occurred primarily in aromatic solvents and the gels manifested typical fibrous or spherical morphologies. The 13C cross-polarized magic angle spinning (CPMAS) NMR spectra measured on the cr…
TGF-β2 silencing to target biliary-derived liver diseases
2020
ObjectiveTGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from bile duct ligated and MDR2 knockout (KO) mouse models for human cholestatic liver disease suggested an involvement of TGF-β2 in biliary-derived liver diseases.DesignAs we also found upregulated TGFB2 in liver tissue of patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), we now fathomed the positive prospects of targeting TGF-β2 in early stage biliary liver disease using the MDR2-KO mice. Specifically, the influence of TgfB2 silencing on the fibrotic and inflammatory niche was analysed on m…
Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices
2019
Fibrosis is the hallmark of pathologic tissue remodelling in most chronic diseases. Despite advances in our understanding of the mechanisms of fibrosis, it remains uncured. Fibrogenic processes share conserved core cellular and molecular pathways across organs. In this study, we aimed to elucidate shared and organ-specific features of fibrosis using murine precision-cut tissue slices (PCTS) prepared from small intestine, liver and kidneys. PCTS displayed substantial differences in their baseline gene expression profiles: 70% of the extracellular matrix (ECM)-related genes were differentially expressed across the organs. Culture for 48 h induced significant changes in ECM regulation and trig…
GDF11 induces mild hepatic fibrosis independent of metabolic health
2020
BACKGROUND & AIMS: Growth Differentiation Factor 11 (GDF11) is an anti-aging factor, yet its role in liver diseases is not established. We evaluated the role of GDF11 in healthy conditions and in the transition from non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH). RESULTS: GDF11 mRNA levels positively correlated with NAFLD activity score and with CPT1, SREBP, PPAR? and Col1A1 mRNA levels, and associated to portal fibrosis, in morbidly obese patients with NAFLD/NASH. GDF11-treated mice showed mildly exacerbated hepatic collagen deposition, accompanied by weight loss and without changes in liver steatosis or inflammation. GDF11 triggered ALK5-dependent SMAD2/…