Search results for "TLE"

Bovine Serum Albumin protofibril-like aggregates formation: Solo but not simple mechanism

2011

We report an experimental study on the model protein Bovine Serum Albumin (BSA), with the aim of elucidating the mechanisms by which a fully folded globular protein undergoes different aggregation pathways leading to the formation of amyloid fibrils or amorphous aggregates. We observe thermally induced formation of fibrillar structures at pH far from the protein isoelectric point. The increase of electrostatic repulsion results in protein destabilization and in modifications of inter and intra-molecular interactions leading to the growth of fibril-like aggregates stabilized by inter-molecular-β sheets. The aggregation kinetics is studied by means of fluorescence techniques, light scattering…

Calorimetric and structural investigation of the interaction between bovine serum albumin and high molecular weight dextran in water.

2005

This work studies specific interactions between a small globular protein and a highly flexible, branched polysaccharide using differential scanning calorimetry (DSC), circular dichroism (CD), fluorescence, and turbidimetry measurements. It uses the system water/bovine serum albumin (BSA)/dextran (D 2000) as a model. Dextran molecules are able to form interpolymeric complexes with BSA in water at both low and high temperatures if the polysaccharide is in excess and if the protein exists in its associated state. It leads to a partial destabilization of the secondary and tertiary structures of the protein and an additional exposure of the hydrophobic tryptophan residues to the surface of globu…

Thermal aggregation and ion-induced cold-gelation of bovine serum albumin

2009

Protein cold-gelation has recently received particular attention for its relevance in bio and food technology. In this work, we report a study on bovine serum albumin cold-gelation induced by copper or zinc ions. Metal-induced cold-gelation of proteins requires two steps: during the first one, the heat treatment causes protein partial unfolding and aggregation; then, after cooling the solution to room temperature, gels are formed upon the addition of metal ions. The thermally induced behaviour has been mainly investigated through different techniques: Fourier transform infrared (FTIR) spectroscopy, circular dichroism, dynamic light scattering (DLS) and rheology. Data have shown that the agg…

Cittadinizzazione e policy migratorie nella Sicilia occidentale : Progettare servizi innovativi rafforzando le Pubbliche Amministrazioni in attuazion…

2021

L’accesso ai servizi della pubblica amministrazione è spesso, per la popolazione migrante, un cercare la chiave giusta fra un numero spropositato di chiavistelli. Evidenziare come l’inserimento di alcuni servizi innovativi, fra i quali gli sportelli Mi.Main (Migration Mainstreaming) progettati e implementati da giovani laureati all’interno degli uffici della P.A., abbia di fatto favorito processi di “cittadinizzazione”, è stato lo scopo di questo volume. Preliminari ad ogni processo di inclusione sono infatti gli “atti di cittadinanza” che attraversano e ancorano l’universalità dei diritti umani al riconoscimento dei bisogni e delle priorità della persona. Questo volume, descrive come due t…

Rural settlement in the territorium of Ilici: the Roman farm of The Cabezo-Clot de Galvany (Elx, Alicante)

2015

Situado en el territorium de Ilici, en el paraje de El Clot de Galvany (Elx), junto a un humedal de tierras pobres, presentamos una granja romana (ss. I-III d.C.). Su posición periférica respecto al área centuriada ilicitana, los restos materiales aparecidos (molinos, ausencia de estructuras de transformación, aislamiento relativo) y la gran simplicidad estructural y funcional del conjunto remarcan el carácter autosuficiente de este núcleo. El área arqueológica tras la época romana queda deshabitada y sólo volvió a frecuentarse a partir del s. XVII, coincidiendo con el crecimiento demográfico de época moderna, como muestra la construcción de una ermita. Todo ello nos lleva a plantear cuesti…

Relative sea-level rise and potential submersion risk for 2100 on 16 coastal plains of the mediterranean sea

2020

The coasts of the Mediterranean Sea are dynamic habitats in which human activities have been conducted for centuries and which feature micro-tidal environments with about 0.40 m of range. For this reason, human settlements are still concentrated along a narrow coastline strip, where any change in the sea level and coastal dynamics may impact anthropic activities. In the frame of the RITMARE and the Copernicus Projects, we analyzed light detection and ranging (LiDAR) and Copernicus Earth Observation data to provide estimates of potential marine submersion for 2100 for 16 small-sized coastal plains located in the Italian peninsula and four Mediterranean countries (France, Spain, Tunisia, Cypr…

Genome-wide detection of signatures of selection in three Valdostana cattle populations

2020

International audience; The Valdostana is a local dual purpose cattle breed developed in Italy. Three populations are recognized within this breed, based on coat colour, production level, morphology and temperament: Valdostana Red Pied (VPR), Valdostana Black Pied (VPN) and Valdostana Chestnut (VCA). Here, we investigated putative genomic regions under selection among these three populations using the Bovine 50K SNP array by combining three different statistical methods based either on allele frequencies (F-ST) or extended haplotype homozygosity (iHS and Rsb). In total, 8, 5 and 8 chromosomes harbouring 13, 13 and 16 genomic regions potentially under selection were identified by at least tw…

Natural reduction of willow carrot aphids by Coccinellidae on a carrot crop

1993

The impact of the Little ice age on coccolithophores in the central Mediterranea Sea

2010

The Little Ice Age (LIA) is the last episode of a series of Holocene climatic anomalies. There is still little knowledge on the response of the marine environment to the pronounced cooling of the LIA and to the transition towards the 20th century global warming. Here we present decadal-scale coccolithophore data from four short cores recovered from the central Mediterranean Sea (northern Sicily Channel and Tyrrhenian Sea), which on the basis of <sup>210</sup>Pb activity span the last 200–350 years. The lowermost part of the record of one of the cores from the Sicily Channel, Station 407, which extends down to 1650 AD, is characterized by drastic changes in productivity. Specific…

Could Europe Apply a Suitable Control Method for the Small Hive Beetle (Coleoptera: Nitidulidae)?

2022

Abstract The European bee, Apis mellifera L. (Hymenoptera: Apidae), is a fundamental resource for the pollination of a great variety of botanical species used by humans for sustenance. Over the last few decades, bee colonies have become vulnerable to a new pest that has advanced beyond its native sub-Saharan territory: the small hive beetle, Aethina tumida Murray (Coleoptera: Nitidulidae). This currently presents a pressing problem in the United States and Australia, but it has also been recorded in Portugal and Italy and it is likely to spread in the rest of Europe too. This study represents a systematic review, based on EFSA guidelines, of the various control treatments for small hive bee…