Search results for "TMP"
showing 10 items of 22 documents
Comprehensive analysis of a Vibrio parahaemolyticus strain extracellular serine protease VpSP37
2015
Proteases play an important role in the field of tissue dissociation combined with regenerative medicine. During the years new sources of proteolytic enzymes have been studied including proteases from different marine organisms both eukaryotic and prokaryotic. Herein we have purified a secreted component of an isolate of Vibrio parahaemolyticus, with electrophoretic mobilities corresponding to 36 kDa, belonging to the serine proteases family. Sequencing of the N-terminus enabled the in silico identification of the whole primary structure consisting of 345 amino acid residues with a calculated molecular mass of 37.4 KDa. The purified enzyme, named VpSP37, contains a Serine protease domain be…
Integrative clinical transcriptome analysis reveals TMPRSS2-ERG dependency of prognostic biomarkers in prostate adenocarcinoma.
2019
In prostate adenocarcinoma (PCa), distinction between indolent and aggressive disease is challenging. Around 50% of PCa are characterized by TMPRSS2‐ERG (T2E)‐fusion oncoproteins defining two molecular subtypes (T2E‐positive/negative). However, current prognostic tests do not differ between both molecular subtypes, which might affect outcome prediction. To investigate gene‐signatures associated with metastasis in T2E‐positive and T2E‐negative PCa independently, we integrated tumor transcriptomes and clinicopathological data of two cohorts (total n = 783), and analyzed metastasis‐associated gene‐signatures regarding the T2E‐status. Here, we show that the prognostic value of biomarkers in PCa…
TMPRSS4: a novel tumor prognostic indicator for the stratification of stage IA tumors and a liquid biopsy biomarker for NSCLC patients
2019
Relapse rates in surgically resected non-small-cell lung cancer (NSCLC) patients are between 30% and 45% within five years of diagnosis, which shows the clinical need to identify those patients at high risk of recurrence. The eighth TNM staging system recently refined the classification of NSCLC patients and their associated prognosis, but molecular biomarkers could improve the heterogeneous outcomes found within each stage. Here, using two independent cohorts (MDA and CIMA-CUN) and the eighth TNM classification, we show that TMPRSS4 protein expression is an independent prognostic factor in NSCLC, particularly for patients at stage I: relapse-free survival (RFS) HR, 2.42 (95% CI, 1.47&ndash
Increasing the probability of finding an interaction in work stress research: A two-wave longitudinal test of the triple-match principle
2010
Research into work stress has attempted to identify job resources that can moderate the effects of job demands on strain. The recently developed triple-match principle (TMP) proposes that job demands, resources, and strain can be conceptualized as being composed of cognitive, emotional, and physical dimensions. When a psychological imbalance is induced by job demands, individuals activate corresponding resources to reduce the effects of the demands. A closer match occurs when the resources are processed in the same psychological domain as the demands. The further away from a match, the less likely an interactive effect will become. Put simply, the likelihood of finding an interactive effect…
Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
2014
Increased expression of metalloprotease meprin β is associated with fibrotic syndromes and Alzheimer's disease (AD). Hence, regulation of meprin activity might be a suitable strategy for the treatment of these conditions. Meprin β is a type 1 transmembrane protein, but can be released from the cell surface by ectodomain shedding. The protease is expressed as an inactive zymogen and requires proteolytic maturation by tryptic serine proteases. In the present study, we demonstrate, for the first time, the differences in the activation of soluble and membrane bound meprin β and suggest transmembrane serine protease 6 [TMPRSS6 or matriptase-2 (MT2)] as a new potent activator, cleaving off the pr…
Evaluation and comparison of satellite precipitation estimates with reference to a local area
2011
Precipitation is one major variable for many applications. Satellite retrieval systems, raingauge network and radar systems are complement to each other in terms of their coverage and capability of monitoring precipitation. Satellite rainfall estimates systems produce data with global coverage that can provide information in areas for which data from other sources are unavailable.Without referring to ground measurement, satellite-based estimates can be bias. Although some gauged adjusted satellite precipitation products are developed, an effective way of integrating multi-sources of precipitation information is still a challenge. In this study we select a specific area in Sicily (Italy) hav…
Dialoghi tra antico e contemporaneo. Dal Bouleuterion greco alla grande Barricaia di Rocca di Frassinello
2021
La cantina Rocca di Frassinello, progettata da Renzo Piano nel cuore della Maremma Toscana, costituisce uno dei massimi esempi di come la contemporaneità, nelle sue forme più essenziali, possa fondersi perfettamente con il paesaggio naturale circostante senza alterarne gli equilibri e la storia ma anzi valorizzandolo in maniera magistrale. Il centro pulsante della cantina è la grande barricaia ipogea nella quale riposano fino a 2.500 barriques di rovere francese disposte su gradinate digradanti. La particolare configurazione a gradoni della barricaia sembra richiamare l'impianto planimetrico di una forma architettonica legata all'antica Grecia, il bouleuterion. Un'iscrizione da Teos attesta…
Factors affecting social integration and transversal skills of college students: a preliminary study
2015
International audience; This research, as a part of a PhD thesis in educational sciences relates to the social network and the transversal skills developed by the Bachelor's degree students ("Licence") in a French college. Overall, this work aims at identifying and estimating origins and effects of student social integration and transversal skills within the college careers. Four areas of student social integration and ten skills stemming from a reference table are measured by an original questionnaire. In this paper, the first preliminary results of this work are presented and reveal the influence of various personal and contextual factors on the integration and skills scores stated by stu…
Implicaciones clínicopatologicas del gen TMPRSS2-ERG y perfil molecular asociado en cáncer de próstata
2013
El cáncer de próstata (CaP) es un problema sanitario de primer orden. Mundialmente, cada año se diagnostican aproximadamente 700.000 casos, de los cuales, 13.300 corresponden a España. En cuanto al manejo clínico, esta enfermedad presenta una serie de problemas que conducen tanto al infraestadiaje como al sobretratamiento de un porcentaje significativo de tumores. En este contexto, en 2005 se descubrió un gen quimérico formado por TMPRSS2 y ERG, presente en aproximadamente la mitad de tumores prostáticos y totalmente específico de este tipo de cáncer. La presente tesis, caracteriza clínica y biológicamente este reordenamiento y un perfil de expresión de genes relacionados a fin de mejorar e…
New Thermoshrinkable Materials of Radiation Modified Polypropylene-Elastomer Composites with Cross-Linking Agents
2014
In this work, electron beam modified heterogeneous composites of isotactic polypropylene (PP) with chlorinated polyethylene (CPE) have been investigated. The PP/CPE blend composites with an excess of elastomer (30/70 wt%) have been modified with trimethylolpropane triacrylate (TMPTA) and bisphenol-A-dimethacrylate (BPDMA) cross-linking agents and have been irradiated with accelerated electrons up to ionizing radiation doses from 25 to 150 kGy. The internal stresses characterizing the thermoshrinkage properties (TMP) thermorelaxation stresses formed in thermal heating and the residual stresses resulting in the process of full setting and cooling of materials have been investigated for radiat…