Search results for "TOXICITY"

Hypotensive Effect ofPistacia lentiscusL

1987

AbstractThe present studies were undertaken to confirm the hypotensive effect of Pistacia lentiscus L. in normotensive urethane anaesthetized Wistar rats. It was shown that lyophilized aqueous extract caused a dose-dependent decreased of the systemic arterial blood pressure. Acute toxicity was also determined. Phytochemical analysis revealed the presence of steroids-triterpenes, catechin tannins, flavonoids, sugars, resins and saponins.

Medicinally Used Asarum Species: High-Resolution LC-MS Analysis of Aristolochic Acid Analogs and In vitro Toxicity Screening in HK-2 Cells

2017

Species of Asarum are used in traditional Chinese medicine and, similar to members of the genus Aristolochia, they contain aristolochic acid analogs (AAAs). These compounds are known for their nephrotoxic and carcinogenic effects. So far, the phytochemistry and nephrotoxicity of species of Asarum is not well studied. A high-resolution LC-MS-based metabolomic approach was used to study the phytochemical variation in medicinally used Asarum species. The cytotoxicity of the samples was assessed using human kidney (HK-2) cells. The majority of samples contained potentially nephrotoxic AAAs, including 9-methoxy aristolactam (AL) IV, AL I, and AL IV. These compounds were present in methanol as we…

The analgesic-antiinflammatory extract fromAraujia sericifera lacks ulcerogenic activity on stress-gastric damage model

1995

The present study evaluates the ulcerogenic activity of the hexane extract from dry fruits of Araujia sericifera in an experimental model of cold-restraint stress. Treatment of rats with 200 mg/kg (i.p.) of hexane extract did not affect the gastric lesions induced by cold-restraint stress. However, it was confirmed that a dose of 300 mg/kg (i.p.) of acetylsalicylic acid (ASA) which induced a similar analgesic-antiinflammatory effect, increased significantly the level of gastric damage. Thus, the hexane extract from the fruits of A. sericifera seems to possess analgesic-antiinflammatory properties which are not linked to gastrolesive effects.

Isolated myocardiocytes and DNA synthesis: a possible experimental model to predict the in vivo cardiotoxicity

1989

Dissimilar effects of doxorubicin and isoproterenol on morphology, H2O2 content and catalase activity in mouse heart

1988

Cardiac lysosomes in doxorubicin cardiotoxicity: An ultrastructural study

1988

Effects of verapamil and N-acetylcysteine on doxorubicin or isoproterenol cardiotoxicity in mice

1989

Contribution of oxidative stress to excitotoxicity-induced deleterious iNOS in the CNS.

1999

Phytotoxic Lignans from Artemisia arborescens

2018

A systematic bioassay-guided fractionation of methylene chloride extracts of the aerial part of Artemisia arborescens was performed in order to identify its phytotoxic compounds Two lignans were isolated, sesamin and ashantin, that inhibited growth of Agrostis stolonifera (bentgrass), a monocot, and Lactuca sativa (lettuce), a dicot, at 1 mg mL–1. In a dose-response screening of these lignans for growth inhibition against Lemna paucicostata (duckweed), ashantin was the most active with an IC50 of ca. 224 μM. The mode of action of these compounds is still unknown. In mosquito larvicidal bioassays the pure compounds sesamin and ashantin did not cause mortality at the highest dose of 125 mg/L…

Perfil de toxicidad y adherencia del esquema farmacoterapéutico gemcitabina-carboplatino en cáncer de pulmón no microcítico

2011

Objective: To analyse the relationship between doses of gemcitabine-carboplatin (GEM-CARBO) administered and incidence and level of haematological and renal toxicity, and the adherence to the treatment in patients with non-small cell lung cancer. Methods: Retrospective study which lasted for 37 months. We were able to obtain the minimum set of data needed to carry out the follow-up with the help of Farmis-Oncofarm® software and the medical and pharmacotherapeutic records. The haematological toxicity was assessed in accordance with the Common Toxicity Criteria 3.0. Renal toxicity was evaluated using serum creatinine levels and creatinine clearance. Results: Thirty-one patients were included …