Search results for "TP"
showing 10 items of 4688 documents
Poly(hydroxyalkanoate) synthase genes in pseudomonads strains, isolation and heterologous expression
2010
S1/3 The stator stalk of Escherichia coli ATP synthase
2008
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
Graphical abstract
P2Y-mediated contractile responses in the longitudinal muscle of mouse distal colon: distinct signaling pathways
2008
Activation of P2Y receptors by ATP and by its analogue, ADPbetaS, triggers two calcium signal pathways in the longitudinal muscle of mouse distal col…
2008
Our previous research showed that ATP and adenosine 5'-O-2-thiodiphosphate (ADPbetaS) induce contractile effects in the longitudinal muscle of mouse distal colon via activation of P2Y receptors which are not P2Y(1) or P2Y(12) subtypes. This study investigated the nature of the P2Y receptor subtype(s) and the mechanisms leading to the intracellular calcium concentration increase necessary to trigger muscular contraction. Motor responses of mouse colonic longitudinal muscle to P2Y receptor agonists were examined in vitro as changes in isometric tension. ATP or ADPbetaS induced muscular contraction, which was not affected by P2Y(11) or P2Y(13) selective antagonists. Calcium-free solution or th…
Agonist-specific Ca2+ signaling at P2Y receptors
2008
Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon
2007
BACKGROUND AND PURPOSE: This study analysed the contribution of the purinergic system to enteric neurotransmission in the longitudinal muscle of mouse distal colon. EXPERIMENTAL APPROACH: Motor responses to exogenous ATP and to nerve stimulation in vitro were assessed as changes in isometric tension. KEY RESULTS: ATP induced a concentration-dependent contraction, reduced by 4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzene disulphonic acid (PPADS), suramin, P2Y purinoreceptor desensitisation with adenosine 5'-O-2-thiodiphosphate (ADPbetaS), and atropine, but unaffected by P2X purinoceptor desensitisation with alpha,beta-methylene ATP (alpha,beta-meATP) an…
1,4-Dihidropiridīnu atvasinājumu nanodaļiņu toksiskuma novērtējums mikroorganismos
2017
1,4 Dihidropiridīnu (1,4 DHP) atvasinājumi ir plaša organisko vielu grupa, kurā arvien tiek sintezēti jauni savienojumi ar plašām pielietojuma iespējām. Jauno savienojumu toksicitātes raksturojums ir nepieciešams, lai paredzētu to pielietojuma iespējas un novērtētu to iedarbību uz vidi un dzīvajiem organismiem. Darbā pielāgota universāla un efektīva atšķaidījumu metode, lai noteiktu deviņu katjono amfifilo 1,4 DHP atvasinājumu toksicitātes robežkoncentrācijas sešām baktērijām un vienam raugam. Papildus noteikta 1,4 DHP atvasinājumu ietekme uz iekššūnas ATP daudzumu, skābekļa patēriņa ātrumu un etīdija bromīda transportu šūnās. Noskaidrojot toksicitātes robežkoncentrācijas un gūstot ieskatu …
Conversion of the Ca2+-ATPase from Rhodospirillum rubrum into a Mg2+-dependent enzyme by 1,N6-etheno ATP
1980
Nucleoside triphosphate hydrolysis of R.rubrum ATPase complexes can be changed from Ca2+-dependence to Mg2+-dependence by replacing ATP with 1,N6-etheno ATP. Four ATPase complexes which have been prepared by different procedures hydrolyze ATP and 1,N6-etheno ATP at different rates in dependence on the added metal ions. These differences allow an easy distinction of the various enzyme forms.
The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots
2005
*† ‡ § Summary Since copper (Cu) is essential in key physiological oxidation reactions, organisms have developed strategies for handling Cu while avoiding its potentially toxic effects. Among the tools that have evolved to cope with Cu is a network of Cu homeostasis factors such as Cu-transporting P-type ATPases that play a key role in transmembrane Cu transport. In this work we present the functional characterization of an Arabidopsis Cutransporting P-type ATPase, denoted heavy metal ATPase 5 (HMA5), and its interaction with Arabidopsis metallochaperones. HMA5 is primarily expressed in roots, and is strongly and specifically induced by Cu in whole plants. We have identified and characteriz…