Search results for "TPP"
showing 10 items of 11 documents
Guanxin Danshen Formulation Protects against Myocardial Ischemia Reperfusion Injury-Induced Left Ventricular Remodeling by Upregulating Estrogen Rece…
2017
Background: Guanxin Danshen formulation (GXDSF) is a traditional Chinese herbal recipe recorded in the Chinese Pharmacopoeia since 1995 edition, which consists of Salviae miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and Dalbergiae odoriferae Lignum. Our previous research suggested GXDSF had positive effect on cardiovascular disease. Therefore, the aim of this study was to elucidate the effects of GXDSF on myocardial ischemia reperfusion injury-induced left ventricular remodelling (MIRI-LVR). Methods: The effects of GXDSF on cardiac function were detected by haemodynamics and echocardiograms. The effects of GXDSF on biochemical parameters (AST, LDH and CK-MB) were analysed. H…
The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated fr…
2016
It is not known if the mitochondria-targeted antioxidants such as mitoquinone (MitoQ) can modulate oxidative stress and leukocyte-endothelium interactions in T2D patients. We aimed to evaluate the beneficial effect of MitoQ on oxidative stress parameters and leukocyte-endothelium interactions in leukocytes of T2D patients. The study population consisted of 98 T2D patients and 71 control subjects. We assessed metabolic and anthropometric parameters, mitochondrial reactive oxygen species (ROS) production, glutathione peroxidase 1 (GPX-1), NFκB-p65, TNFα and leukocyte-endothelium interactions. Diabetic patients exhibited higher weight, BMI, waist circumference, SBP, DBP, glucose, insulin, HOMA…
Investigation of the aqueous transmetalation of π-allylpalladium with indium salt: the use of the Pd(OAc)2–TPPTS catalyst
2005
pi-Allylpalladium complexes could be generated in water by the palladium(0) water soluble catalyst prepared in situ from palladium acetate and TPPTS. These complexes were transmetalated with indium to react with benzaldehyde. The aqueous solution of Pd(0)(TPPTS)(n) could be reused without deterioration of the catalyst in the first and second recycling. The system proved to be efficient with primary and secondary allylic substrates. The stereochemical outcome of the allylation through umpolung of allylpalladium, was also studied using models with a restraint conformation.
An ANN model to correlate roughness and structural performance in asphalt pavements
2017
Abstract In this paper, using a large database from the Long Term Pavement Performance program, the authors developed an Artificial Neural Network (ANN) to estimate the structural performance of asphalt pavements from roughness data. Considering advantages of modern high-performance survey devices in the acquisition of road pavement functional parameters, it would be of practical significance if the structural state of a pavement could be estimated from its functional conditions. To differentiate various road section conditions, several significant input parameters, related to traffic, weather, and structural aspects, have been included in the analysis. The results are very interesting and …
Everything you wanted to know about phase and reference frequency in one- and two-dimensional NMR spectroscopy
2019
The fundamental concept of phase discussed in this tutorial aimed at providing students with an explanation of the delays and processing parameters they may find in nuclear magnetic resonance (NMR) pulse programs. We consider the phase of radio-frequency pulses, receiver, and magnetization and how all these parameters are related to phases and offsets of signals in spectra. The impact of the off-resonance effect on the phase of the magnetization is discussed before presenting an overview of how adjustment of the time reference of the free induction decay avoids first-order correction of the phase of spectra. The main objective of this tutorial is to show how the relative phase of a pulse an…
ASV starptautiskās tirdzniecības politikas maiņa no daudzpusējiem uz divpusējiem līgumiem
2019
Maģistra darba nosaukums ir “ASV starptautiskās tirdzniecības politikas maiņa no daudzpusējiem uz divpusējiem līgumiem”. Darba mērķis ir noskaidrot ASV politikas maiņas potenciālo ietekmi uz tās ekonomiku un politiku, izstājoties no Klusā okeāna partnerības. Autors ir izvirzījis hipotēzi - īstenojot šādu starptautiskās tirdzniecības politikas maiņu ASV ekonomiski un politiski būs lielāka zaudētāja nekā TPP līguma dalībvalstis. Dotā darba uzdevumi: apskatīt ASV tirdzniecības politiku pēc Aukstā kara, apskatīt jau esošo daudzpusējo līgumus un izvērtēt to ietekmi uz dalībvalstu ekonomiku. Pētījuma secinājumi un rezultāti norāda uz to, ka ASV ir zaudētāja izstājoties no TPP un izvirzītā hipotēz…
Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy
2008
Cancer continues to be one of the major health and socio-economic problems worldwide, despite considerable efforts to improve its early diagnosis and treatment. The identification of new constituents as biomarkers for early diagnosis of neoplastic cells and the discovery of new type of drugs with their mechanistic actions are crucial to improve cancer therapy. New drugs have entered the market, thanks to industrial and legislative efforts ensuring continuity of pharmaceutical development. New targets have been identified, but cancer therapy and the anti-cancer drug market still partly depend on anti-mitotic agents. The objective of this paper is to show the effects of KAR-2, a potent anti-m…
Orthometalation of Tris(3-sodium sulfonatophenyl)phosphine with Dirhodium(II) Acetate
1998
Tetraacetatodirhodium(II) reacts with tris(3-sodium sulfonatophenyl)phosphine (TPPTS) giving [Rh2(μ-OOCCH3)3{μ-(3-NaO3SC6H3)P(C6H4SO3Na-3)2}(HOOCCH3)]·6H2O (1) and [Rh2(μ-OOCCH3)2{μ-(3-NaO3SC6H3)P(C6H4SO3Na-3)2}2(HOOCCH3)]·12H2O (2). Their structures and properties have been studied by electronic, IR, and 31P{1H}, 1H, 1H{31P}, and 13C{1H} NMR spectroscopies. In compound 1, one of the acetate bridges is replaced by a phosphine ligand, orthometalated via the C2 carbon atom of the phenyl ring. One axial site of the Rh24+ core is occupied by a sulfonato group of the metalated ring and another one by a labile molecule of acetic acid. 1H NMR spectroscopy shows that chemical shifts of the aromatic…
Using exomarkers to assess mitochondrial reactive species in vivo
2014
Background:\ud The ability to measure the concentrations of small damaging and signalling molecules such as reactive oxygen species (ROS) in vivo is essential to understanding their biological roles. While a range of methods can be applied to in vitro systems, measuring the levels and relative changes in reactive species in vivo is challenging.\ud \ud Scope of review:\ud One approach towards achieving this goal is the use of exomarkers. In this, exogenous probe compounds are administered to the intact organism and are then transformed by the reactive molecules in vivo to produce a diagnostic exomarker. The exomarker and the precursor probe can be analysed ex vivo to infer the identity and a…
Ideas, conceptos y dilemas para la implementación de una plataforma nacional de ODR en materia de consumo en Chile desde la perspectiva UE
2019
En la presente tesis hemos desarrollado una extensiva investigación monográfica en busca del concepto de ODR (online dispute resolution), el cual se encuentra en un constante desarrollo en el quehacer jurídico procesal comparado, sobre todo en materia del derecho de consumidor en el espacio de integración de la Unión Europea, con el impulso otorgado a la materia por la directiva 2011/2013 EU y el Reglamento 534/2013 EU,y la consecuente transposición de dichas normas a las tradiciones jurídicas de los Estados miembros. La búsqueda para generar un marco jurídico cada vez más proclive al consumidor dentro del mercado único europeo, ha impulsado el desarrollo de la legislación comunitaria, y la…