Search results for "TRANSFORMATION"
showing 10 items of 1634 documents
Recent results on syntactic groups of prefix codes
2012
International audience; We give a simplified presentation of groups in transformation monoids. We use this presentation to describe two recent results on syntactic groups of prefix codes. The first one uses Sturmian words to build finite bifix codes with a given permutation group as syntactic group. The second one describes a class of prefix codes such that all their syntactic groups are cyclic.
Exclusion of PAX9 and MSX1 mutation in six families affected by tooth agenesis. A genetic study and literature review
2013
Objectives: In the present study, it is described the phenotypical analysis and the mutational screening, for genes PAX9 and MSX1, of six families affected by severe forms of tooth agenesis associated with other dental anomalies and systemic entities. Study Design: Six families affected by severe tooth agenesis associated with other dental anomalies and systemic entities were included. Oral exploration, radiological examination, medical antecedents consideration and mutational screening for PAX9 and MSX1 were carried out. Results: No mutations were discovered despite the fact that numerous teeth were missing. An important phenotypical variability was observed within the probands, not being …
Diagnóstico en educación y transiciones
2014
RESUMENEl artículo presenta una reflexión sobre el papel del Diagnóstico en Educación en las transiciones. Las premisas clásicas del diagnóstico tradicional se desmoronan con la incorporación de nuevas consideraciones relacionadas con el carácter procesual, la impredecibilidad del futuro y cambios sociales y con las nuevas tendencias metodológicas del diagnóstico. Desde una perspectiva sistémica, se sugiere un diagnóstico centrado en dos áreas prioritarias: a) la exploración de las causas que impiden el desarrollo de los individuos y el proceso de transformación de sus habilidades y, b) el compromiso paralelo con una transformación educativa y social. Asimismo, el artículo repasa el sentido…
Friction forces and patient-centredness: Understanding how established logics endure during infrastructure transformation
2017
n this article, we examine three cases of e-health solutions for patients in Norway. For the analysis of the three cases, we focused on friction forces that come into play when different established arrangements need to change to accommodate novelty. We argue that the design of new technologies was shaped by friction related to institutionalised practices, regulatory regimes and entrenched patient roles. These friction forces connect the past with the present, come into action when aiming for novelty and result to the perpetuation of constituents of the past during change processes. Specifically, the e-health solutions under study were strongly influenced by established healthcare provision…
The Role of Business Models in Developing Business Networks
2008
Business models have received a substantial amount of interest recently. Also, various research studies have discussed business models, especially in the context of a single company operating in mass markets. Unfortunately, these models often are not applicable for complex products or services that build on long-term knowledge about customer tastes, facilities, and skills. Especially on global markets, the asset specificity and vast geographical distances make it difficult for any single company to provide this kind of service cost-efficiently on a large scale. Instead, it calls for cooperation among multiple firms. Creation of a joint business model for a collaborative network is a necessa…
Applying a Dynamic Performance Management Framework to Wicked Issues: How Coproduction Helps to Transform Young People's Services in Surrey County Co…
2017
This article explores how a dynamic performance management (DPM) approach can give policy makers a more integrated, time-related understanding of how to address wicked problems successfully. The article highlights how an outcome-based approach to solving wicked policy problems has to balance three very contrasting objectives of stakeholders in the policy making process-improving service quality, improving quality of life outcomes and improving conformity to the principles of public governance. Simultaneous achievement of these three objectives may not be feasible, as they may form an interactive dynamic system. However the balancing act between them may be achieved by the use of DPM. Policy…
Information Infrastructures for eHealth
2017
This chapter provides an introductory overview of healthcare information systems, followed by a more detailed discussion on two types of core components in a public eHealth infrastructure: e-prescription solutions and governmental patient-oriented platforms. E-prescription solutions support the electronic flow of information for prescribed medications between prescribers, pharmacies and insurers that handle related payments. E-prescription solutions aim for cost containment, enhancement of patient safety, control over doctors’ prescription patterns and process quality assurance. Governmental platforms for patient- or citizen-oriented eHealth services typically offer patients access to gener…
Run-time profiling of functional logic programs
2005
In this work, we introduce a profiling scheme for modern functional logic languages covering notions like laziness, sharing, and non-determinism. Firstly, we instrument a natural (big-step) semantics in order to associate a symbolic cost to each basic operation (e.g., variable updates, function unfoldings, case evaluations). While this cost semantics provides a formal basis to analyze the cost of a computation, the implementation of a cost-augmented interpreter based on it would introduce a huge overhead. Therefore, we also introduce a sound transformation that instruments a program such that its execution—under the standard semantics—yields not only the corresponding results but also the a…
Therapeutic targeting of apoptotic pathways in cancer.
2006
Programmed cell death (apoptosis) is a key tumor suppressor mechanism. Consequently, most if not all cancers develop mechanisms to abolish or circumvent this genetic program. Besides enabling malignant transformation and tumor progression, defects in apoptosis can result in resistance to cytotoxic cancer therapies. Much progress has been made in the delineation of the molecular pathways leading to apoptosis. This allows the identification of target molecules and lead compounds to develop novel therapies, which make use of this intrinsic death program for the treatment of cancer. Here, we review the current understanding of apoptotic signal transduction pathways, and strategies of their ther…
Iron Metabolism in the Tumor Microenvironment-Implications for Anti-Cancer Immune Response
2021
New insights into the field of iron metabolism within the tumor microenvironment have been uncovered in recent years. Iron promotes the production of reactive oxygen species, which may either trigger ferroptosis cell death or contribute to malignant transformation. Once transformed, cancer cells divert tumor-infiltrating immune cells to satisfy their iron demand, thus affecting the tumor immunosurveillance. In this review, we highlight how the bioavailability of this metal shapes complex metabolic pathways within the tumor microenvironment and how this affects both tumor-associated macrophages and tumor-infiltrating lymphocytes functions. Furthermore, we discuss the potentials as well as th…