Search results for "TRES"
showing 10 items of 6927 documents
Dendritic cells lentivirally engineered to overexpress interleukin-10 inhibit contact hypersensitivity responses, despite their partial activation in…
2010
Background Dendritic cells (DCs) constitute an attractive target for immunotherapeutic approaches. Because DCs are largely refractory to transfection with plasmid DNA, several viral transduction protocols were established. The potential side-effects of lentiviral transduction on the phenotype and activation state of DCs left unstimulated after transduction have not been assessed. There is a need to analyse these parameters as a result of the requirement of using DCs with a low activation state for therapeutic strategies intended to induce tolerance. Methods Lentivirally-transduced bone marrow (BM)-derived DCs (LV-DCs) in comparison with mock-transduced (Mock-DCs) and untreated DCs were anal…
Stability of radial head and neck fractures: a biomechanical study of six fixation constructs with consideration of three locking plates.
2007
Open reduction and internal fixation of radial neck fractures can lead to secondary loss of reduction and nonunion due to insufficient stability. Nevertheless, there are only a few biomechanical studies about the stability achieved by different osteosynthesis constructs.Forty-eight formalin-fixed, human proximal radii were divided into 6 groups according to their bone density (measured by dual-energy x-ray absorptiometry). A 2.7-mm gap osteotomy was performed to simulate an unstable radial neck fracture, which was fixed with 3 nonlocking implants: a 2.4-mm T plate, a 2.4-mm blade plate, and 2.0-mm crossed screws, and 3 locking plates: a 2.0-mm LCP T plate, a 2.0-mm 6x2 grid plate, and a 2.0…
Saikne starp stresu un darbaspējām māsām un medicīnas personālam
2018
Pētījuma mērķis tika sasniegts izpildot pētījuma uzdevumus, kuri iekļauj trīs pamatdaļas: 1. starptautiskas aptaujas validēšanu un pielāgošanu Latvijas populācijai; 2. aptaujas veikšanu medicīnas darbinieku vidē saskaņā ar starptautisku protokolu; 3. sasniegto atbilžu statistisko apstrādi un secinājumu veidošanu. Pētījuma hipotēzes: 1. Pastāv negatīva saikne starp darba stresu un darbaspējām medicīnas darbinieku vidē; 2. Darba vides stresa ietekme uz māsu un medicīnas darbinieku darbaspējām dažādās vecuma grupās ir atšķirīga. Izvirzītās hipotēzes apstiprinājās. Pētījuma rezultāti: Pētījuma kvalitatīvajā daļā tika paradītas atšķirības, anketas jautājumu izpratnē, starp latviski un krieviski …
Stress un izdegšana medicīnas un psiholoģijas studentiem
2022
Bakalaura darba pētījuma mērķis bija izpētīt uztvertā akadēmiskā stresa un akadēmiskās izdegšanas saistību medicīnas un psiholoģijas studentiem, kā arī noskaidrot vai pastāv nozīmīgas atšķirības starp medicīnas un psiholoģijas studentu uztvertā akadēmiskā stresa līmeni un akadēmiskās izdegšanas risku. Pētījumā piedalījās 66 respondenti, (59 sievietes, 7 vīrieši), vecumā no 19 līdz 46 gadiem (M=23,27; SD=22,24). Datu ievākšanai tika izmantotas divas aptaujas, Uztvertā akadēmiskā stresa aptauja (Perception of Academic Stress (PAS); Bedewy & Gabriel, 2015) un Maslakas izdegšanas sindroma aptauja- Studentu versija (Maslach Burnout Inventory-Student Survey (MBI-SS); Schaufeli, Martinez, Pinto, S…
Medicīnas studentu empātijas, uztvertā stresa un subjektīvās labklājības saistības
2020
Medicīniskā izglītība ir plaši zināma kā lielus resursus pieprasošs process, kas var izraisīt dažādas psiholoģiskās problēmas, kas, savukārt, var samazināt studentu empātijas un apmierinātības ar dzīvi līmeni. Bakalaura darba mērķis bija apkopot šobrīd zināmo informāciju par empātiju, uztverto stresu, subjektīvo labklājību un šo konstruktu saistībām; noteikt, vai starp medicīnas studentu dzimumu un studiju kursu pastāv atšķirības šo trīs mainīgo mērījumu rezultātos; noskaidrot, vai starp tiem pastāv saistības; balstoties uz saistību ciešumu, atlasīt tos mainīgos lielumus, kas vislabāk izskaidro apmierinātību ar dzīvi šajā izlasē un šajā pētījumā. Pētījuma izlasi veido 216 studenti no medicī…
What we learn about bipolar disorder from large-scale neuroimaging
2020
Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Workin…
Sex-specific effects of natural and sexual selection on the evolution of life span and ageing in Drosophila simulans
2014
Summary Variation in the strength of age-dependent natural selection shapes differences in ageing rates across species and populations. Likewise, sexual selection can promote divergent patterns of senescence across the sexes. However, the effects of these processes on the evolution of ageing have largely been considered independently, and interactions between them are poorly understood. We use experimental evolution to investigate how natural and sexual selection affect life span and ageing in Drosophila simulans. Replicate populations were evolved under lifetime monogamy (relaxed sexual selection) or lifetime polyandry (elevated sexual selection) and at one of two temperatures, 25 °C (rela…
Antioxidant effect of melanoidins after induction of oxidative stress in isolated rat hepatocytes
2002
Se estudia el efecto de las melanoidinas en el estrés oxidativo inducido por adriamicina en hepatocitos aislados de rata. Las melanoidinas presentan un efecto protector, incrementando la viabilidad celular y protegiendo a los lípidos y a las proteínas del estrés oxidativo Melanoidins have a protective effect over macromolecules. They increase cellular viability and protect lipids and proteins from oxidative stress
Ecophysiological and molecular processes involved in water stress memory in pea: from gene expression regulation to plant hydromineral nutrition
2022
Climate change induces increasingly frequent periods of water deficits during the crop cycle. These periods of water stress negatively impact the plant, notably by limiting the availability of resources (water, mineral elements) and by limiting carbon fixation by the plant. In this context, several studies highlighted the beneficial effect of “priming” of a first stress on the response to a second stress by the induction of a transcriptional memory. This memory depends on epigenetic modifications implemented during the first stress. These modifications can regulate the expression of genes known as “memory genes” which have been characterized in the aerial parts of Arabidospsis and maize. Ho…
Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset
2019
ObjectiveMany cancer patients complain about cognitive dysfunction. While cognitive deficits have been attributed to the side effects of chemotherapy, there is evidence for impairment at disease onset, prior to cancer-directed therapy. Further debated issues concern the relationship between self-reported complaints and objective test performance and the role of psychological distress.MethodWe assessed performance on neuropsychological tests of attention and memory and obtained estimates of subjective distress and quality of life in 27 breast cancer patients and 20 healthy controls. Testing in patients took place shortly after the initial diagnosis, but prior to subsequent therapy.ResultsWhi…