Search results for "TRIP"
showing 10 items of 2134 documents
Crystal structure of the tripeptideN-(benzyloxycarbonyl)glycylglycyl-L-norvaline
2015
The title tripeptide, C17H23N3O6, contains a nonproteinogenic C-terminal amino acid residue, norvaline, which is an isomer of the amino acid valine. Norvaline, unlike valine, has an unbranched side chain. The molecule has a Gly–Gly segment which adopts an extended conformation. The norvaline residue also adopts an extended backbone conformation while its side chain has ag+tconformation. In the crystal lattice, N—H...O and O—H...O hydrogen bonds stabilize the packing. Molecules translated along the crystallographicaaxis associate through an N—H...O hydrogen bond. The remaining three hydrogen bonds are between molecules related by a21screw axis.
Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.
2013
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…
¿Cómo impulsa la Comunicación Integrada de Marketing la satisfacción del huésped?: una propuesta a través del conocimiento ecológico y la co-creación…
2022
[ES] La creciente necesidad de aumentar la eficacia de las estrategias de comunicación en el sector hotelero impulsa la investigación acerca de cómo es posible intensificar sus efectos. De entre las distintas alternativas, el enfoque CIM basado en la sostenibilidad empieza a adquirir cada vez más importancia. El presente trabajo tiene como objetivo examinar las relaciones entre la CIM para la sostenibilidad, el conocimiento ecológico, la co-creación de valor y la satisfacción. Sobre la base de los efectos en cadena que se investigan, se propone un modelo teórico, que se contrasta a partir de un estudio empírico con una muestra de 303 huéspedes, en hoteles de Kyiv (Ucrania). Los resultados r…
The first catalytic method for Heck alkynylation of unactivated aryl bromides (copper-free Sonogashira) in an ionic liquid: 1 mol-percent palladium/t…
2007
Herein we report the studies of Heck alkynylation (copper-free Sonogashira) with aryl halides (I, Br, Cl) employing various metallic precursors, tertiary phosphanes and bases in [BMIM][BF4] as the solvent. As a result, we provide the first method that allows the coupling of a large array of substrates, either activated or deactivated bromides in an ionic liquid. Furthermore, the system of highest efficiency is unexpectedly the simplest and cheaper combination that employs [Pd(η3-C3H5)Cl]2/PPh3 at only a 1 mol-% loading with pyrrolidine as the base and in the absence of a copper salt. The coupling of sterically and electronically deactivated bromides bearing different functional groups to ar…
Crystal structure ofcis-1-phenyl-8-(pyridin-2-ylmethyl)dibenzo[1,2-c:2,1-h]-2,14-dioxa-8-aza-1-borabicyclo[4.4.0]deca-3,8-diene
2017
The present work describes the synthesis and crystal structure of the new B-phenyloxazaborocine, C26H23BN2O2. The title compound adopts a zwitterionic form with a significant intramolecular N→B dative bond and intermolecular C—H⋯O interactions connecting molecules parallel to the b axis.
Crystal structure of a low-spin poly[di-μ3-cyanido-di-μ2-cyanido-bis(μ2-2-ethylpyrazine)dicopper(I)iron(II)]
2019
In the title metal–organic framework, [Fe(C6H8N2)2{Cu(CN)2}2] n , the low-spin FeII ion lies at an inversion centre and displays an elongated octahedral [FeN6] coordination environment. The axial positions are occupied by two symmetry-related bridging 2-ethylpyrazine ligands, while the equatorial positions are occupied by four N atoms of two pairs of symmetry-related cyanide groups. The CuI centre is coordinated by three cyanide carbon atoms and one N atom of a bridging 2-ethylpyrazine molecule, which form a tetrahedral coordination environment. Two neighbouring Cu atoms have a short Cu...Cu contact [2.4662 (7) Å] and their coordination tetrahedra are connected through a common edge between…
A propósito de la localización de una pintura sobre tabla de ?La Virgen de la Leche?, del siglo XIV, atribuida a Bernabé de Módena, que perteneció al…
2020
The castle's Hermitage of Yecla (Region of Murcia) constituted during the 13th to 16th centuries the first parish of the population, hosting a triptych-shaped altarpiece presided over by a tempera painting on wood of Our Lady of Humility or "Virgo Lactans", dated around 1370 and attributed to the painter Barnaba da Modena, which was the titular image of the mentioned temple under the title of Our Lady of the Incarnation, until at the end of the 18th century it changed ownership for the Conception of Our Lady. The table at averages of the eight hundred was placed in an a loft, appropriating it at the beginning of the 20th century by the retired military Pascual Spuche y Lacy, who sold it aro…
CCDC 1985146: Experimental Crystal Structure Determination
2020
Related Article: Adrien T. Normand, E. Daiann Sosa Carrizo, Corentin Magnoux, Esteban Lobato, Hélène Cattey, Philippe Richard, Stéphane Brandès, Charles H. Devillers, Anthony Romieu, Pierre Le Gendre, Paul Fleurat-Lessard|2021|Chemical Science|12|253|doi:10.1039/D0SC04736H
Conocimiento del déficit Alfa1-antitripsina y de la discinesia ciliar primaria por estudiantes de medicina y profesionales sanitarios
2015
El déficit de alfa-1-antitripsina (DAAT) y la discinesia ciliar primaria (DCP), se engloban dentro de las enfermedades raras, siendo sin embargo trastornos genéticos y hereditarios con una prevalencia nada desdeñable. En ellas, el infradiagnóstico y el retraso diagnóstico son una constante y característica común. Dado que una de las posibles causas de este problema puede ser el bajo grado de conocimiento de ambas enfermedades por parte de los profesionales que atienden a este tipo de pacientes, y al hecho de que un diagnóstico tardío va a impedir la adopción precoz de medidas preventivas que podrían mejorar su evolución, creímos importante focalizar esta cuestión sobre el grupo de profesion…
CCDC 1942682: Experimental Crystal Structure Determination
2019
Related Article: Xiting Yuan, Cunfa Sun, Xihua Li, Sami Malola, Boon K. Teo, Hannu Häkkinen, Lan-Sun Zheng, Nanfeng Zheng|2019|J.Am.Chem.Soc.|141|11905|doi:10.1021/jacs.9b03009