Search results for "TX"
showing 10 items of 509 documents
Improving Brain Creatine Uptake by Klotho Protein Stimulation: Can Diet Hit the Big Time?
2021
Creatine plays a pivotal role in cellular bioenergetics, acting as a temporal and spatial energy buffer in cells with high and fluctuating energy requirements (1). Jeopardizing delicate creatine homeostasis can be detrimental to many energy-demanding tissues, including the brain. For instance, cerebral creatine hypometabolism accompanies various neurological conditions, including a number of developmental disorders (2, 3), neurodegenerative and cerebrovascular diseases (4, 5), and brain cancer (6). A reduced creatine availability in the brain has been thus recognized as an apposite therapeutic target, and supplying exogenous creatine to compensate for a disease-driven shortfall emerged as a…
Estudios clínicos sobre la enfermedad celíaca (2014-2019): revisión sistemática de la prevalencia de la presentación clínica y enfermedades asociadas…
2020
Introducción: La enfermedad celíaca (EC) se caracteriza por una gran variedad de signos, síntomas y enfermedades asociadas en su forma de presentación, incluso puede cursar de forma asintomática. Recientes estudios muestran la variación del espectro clínico según la edad. En niños y niñas pequeñas predomina la forma clásica con síntomas como distensión abdominal, disminución del apetito, diarrea y pérdida de peso. Las manifestaciones atípicas frecuentes en niños mayores son dolor abdominal, estreñimiento, reflujo, vómitos, fatiga, talla baja. En adultos se observa una reducción de la forma de presentación clásica e incremento de la no clásica.Material y métodos: Se realizó una revisión sist…
Deploying Genome Editing Tools for Dissecting the Biology of Nut Trees
2019
Walnuts are among the most important nut crops grown in temperate regions of the world. Commercial production in California, and increasingly worldwide, relies on only few clonally grafted scion genotypes, particularly “Chandler,” and more recently clonally propagated disease-resistant rootstocks. Diseases, nematodes, insect pests, abiotic stresses, and other nutritional and environmental factors, can reduce walnut productivity and quality, affecting grower profitability. The California Walnut Breeding Program at UC Davis has developed and released scion cultivars and rootstocks to help address some of these problems. Sequencing of the walnut genome is expected to speed walnut breeding by f…
Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity Habits
2020
While the detrimental effects of a chronic positive energy balance due to a sedentary lifestyle have been well established, the impacts of a short period of abruptly reduced physical activity and overeating arising from strict confinement due to the COVID-19 pandemic will soon start to emerge. To reasonably anticipate major consequences according to the available evidence, we hereby review the literature for studies that have explored the health impacts of several weeks of a reduction in physical activity and daily step-count combined with modified eating habits. These studies identify as main metabolic consequences increases in insulin resistance, total body fat, abdominal fat and inflamma…
Anti-proliferative effect of main dietary phytosterols and β-cryptoxanthin alone or combined in human colon cancer Caco-2 cells through cytosolic Ca+…
2015
β-cryptoxanthin (β-Cx) and phytosterols (Ps) have potential against different cancer types, including colon cancer. However, their combined action has not been reported so far. Human colon cancer Caco-2 cells were treated 24 h with β-Cx and/or main dietary Ps (β-sitosterol, campesterol and stigmasterol), alone or in combination, at concentrations compatible with physiological human serum levels. A decrease in cell viability due to apoptosis (rise in sub-G1 population and exposure of membrane phosphatidylserine) was accompanied with dephosphorylation of BAD, mitochondrial depolarization and caspase 3-dependent PARP cleavage, with intracellular Ca2+ influx and increase of RONS levels as initi…
Lifetime total and beverage specific - alcohol intake and prostate cancer risk: a case-control study
2004
Abstract Background We investigated lifetime alcohol consumption and prostate cancer risk in a case-control study conducted in Buffalo, NY (1998–2001). Methods The study included 88 men, aged 45 to 85 years with incident, histologically-confirmed prostate cancer and 272 controls. We conducted extensive in-person interviews regarding lifetime alcohol consumption and other epidemiologic data. Results Prostate cancer risk was not associated with lifetime intake of total and beverage specific ethanol. In addition we found no association with number of drinks per day (average drinks per day over the lifetime) or drinks per drinking day (average drinks per day on drinking days only over the lifet…
BMI-BFMNU: A structural index linked to fat mass
2021
Abstract Introduction: Body mass index (BMI) provides little information on body composition. For example, two people with the same BMI might have different body compositions. In this sense, the development of a new BMI able to provide body composition information is of clinical and scientific interest. The aim of the study was to suggest a new modified BMI formula. Material and Methods: A total of 108 subject, females 56 and males 52, 0-73 years old, in various physiopathological conditions were evaluated. Data were collected and processed by a program that through anthropometric measurements calculates classic BMI, volume, surface, V/S (that we can defined like a body-thickness “pse…
Estudio del estado nutricional de estudiantes de educación primaria y secundaria de la provincia de Valencia y su relación con la adherencia a la Die…
2014
Introducción: La obesidad infantil está alcanzando cifras muy elevadas entre la población infantil española favoreciendo la obesidad en la edad adulta. El objetivo del presente estudio es conocer el estado nutricional de estudiantes de seis colegios de la provincia de Valencia y su grado de adhesión a la Dieta Mediterránea (DM).Material y métodos: Estudio transversal en el que participaron 777 estudiantes, 49,9% eran chicos y 50,1% chicas con edades comprendidas entre 8 y 16 años. Se determinó el peso y la altura de cada participante y se calculó el Índice de Masa Corporal (IMC). A partir del IMC se calculó el Z-score. Para determinar el grado de adhesión a la DM se utilizó el test KidMed.R…
Mirando hacia atrás para vislumbrar el futuro de la Revista Española de Nutrición Humana y Dietética: líneas estratégicas 2017
2016
Se realiza una valoración de los logros alcanzados por la revista RENHyD en estos últimos años, así como por aquellas acciones desarrolladas que han conllevado resultados no satisfactorios. Las lecciones aprendidas, en este recorrido, han ayudado a definir las líneas estratégicas a desarrollar en este próximo año. Estas líneas que se presentan tienen por finalidad incrementar la calidad formal de la revista de acuerdo con los estándares internacionales, lo cual posibilitará la indexación en más bases de datos bibliográficas de ámbito internacional.