Search results for "TYR"
showing 10 items of 2017 documents
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and …
2009
Heme oxygenase-1 (HO-1) is highly protective in various pathophysiological states such as cardiovascular and neurodegenerative diseases. HO-1-derived bilirubin is an efficient scavenger of reactive oxygen and nitrogen species (RONS). It remains to determine whether conversion of biliverdin to bilirubin is an essential step for HO-1-conferred protection of endothelial cells. RONS scavenging activities of biliverdin versus bilirubin were assessed by different RONS generating systems and detection techniques. We also silenced the biliverdin reductase (BVR) or HO-1 gene in cultured primary human endothelial cells (HUVECs) and measured the effect on RONS formation upon stimulation with lipopolys…
Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promot…
1997
Interleukin-12 (IL-12) is a proinflammatory cytokine produced by antigen-presenting cells in response to many microbial infections. IL-12 plays an important role in the generation of T helper type-1 cells, which favor cell-mediated immune response. IL-12 is composed of two different subunits, p40 and p35, whose expression can be regulated concomitantly or differentially. Monocytic cells, the major producers of IL-12, can be primed by interferon-gamma (IFN-gamma) to produce optimal amounts of IL-12 in response to LPS stimulation as a consequence of bacterial infection. The priming effect is exerted primarily at the transcriptional level on the p40 promoter in conjunction with the effects of …
Estimation of the size of liposomes by modified HDC
1991
Internal calibration in modified hydrodynamic chromatography has been realized by the approach of Prieve and Hoysan, i.e. the use of polystyrene monodisperse latexes to evaluate the equivalent capillary radius, R. The value obtained has been used to estimate the average sizes of a variety of liposome samples from egg yolk lecithin.
Phase I metabolites (organic acids) of gamma‐hydroxybutyric acid–validated quantification using GC–MS and description of endogenous concentration ran…
2020
Gamma-hydroxybutyric acid (GHB) is a sedative drug used in drug-facilitated crimes. Its detection window is very short. GHB undergoes intensive phase I metabolism to organic acids (glycolic acid, succinic acid, dihydroxybutyric acids). These could be potential analytical targets to broaden the detection window. The aim of the present study was to enable the detection of endogenous levels of these metabolites in biological samples (blood and urine). A gas chromatographic-mass spectrometric method using liquid-liquid extraction and derivatization with N-methyl-N-tri-methylsilyltrifluoracetamide was developed for the quantification. Validation results were consistent with international guideli…
The cloud of Thecla and the construction of her character as a virgin (παρθένος), martyr (μάρτυς) and apostle (ἀπόστολος)
2019
In the Acts of Paul and Thecla (APTh) a cloud appears in the most important scenes of the tale. This motif is used to highlight the protection offered by God on behalf of the young woman and echoes that cloud appearing in Exodus guiding and protecting the Israelites. Thanks to these kinds of echoes, the author of the APTh tries to establish a connection between both scenes in his readers’ minds and builds, at the same time, the character of Thecla, portrayed as a virgin, a martyr or an apostle in different scenes of the narration. En los Hechos de Pablo y Tecla (APlTh) aparece una nube en algunas de las escenas más importante de la narración. Este motivo es utilizado para resaltar la protec…
‘Non humana viscera sed centies sestertium comesse’ (Petr. Sat. 141,7): Philomela and the Cannibal Heredipetae in the Crotonian Section of Petronius’…
2013
The connection between the themes of money and death is widespread in Petronius' Satyricon, and is definitely not limited to the Cena Trimalchionis, where it has been widely examined. The aim of my paper is to consider the peculiar form that the motif takes in the Crotonian section of Petronius' Satyricon, and its connections with the mythical memory of the Procne and Philomela story. The theme of corpses dismemberment appears at the end of the episode of the shipwreck, the one immediately preceding the Crotonian section, through Encolpius' reflections on the sepultura practice and the destiny of human bodies after our death (Petronius, Satyricon 115, 6-19); the same theme closes the introd…
IMAGINED REBELLION: WHAT DOESN'T HAPPEN IN THE WINTER'S TALE
2014
International audience; Shakespeare's The Winter's Tale features a pattern of violent rebellion that only just fails to happen. Such moments of near-rebellion, best interpreted through the play's master trope of the moving statue, constitute an exploration of the causes of political rebellion and how best to avert it. Thanks to the close integration of its romance aesthetics and political realism, The Winter's Tale can be read as a "Mirror for Kings".
Dendritic cells in liver injury and fibrosis: shortcomings and promises.
2013
SummaryThe phenotype and function of liver dendritic cells (LDCs) are poorly understood. This Snapshot summarizes our current knowledge on LDCs in the healthy and injured liver, and their role in fibrosis progression and reversal. It also draws attention to various pitfalls in the current experimental design and conclusions based on available data.
MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease
2015
Background & Aim Homozygosity for a common non-coding rs4374383 G>A polymorphism in MERTK (myeloid-epithelial-reproductive tyrosine kinase) has been associated with the protection against fibrosis progression in chronic hepatitis C. The main study objective was to assess whether MERTK AA genotype influences liver fibrosis, and secondarily MERTK expression in patients with non-alcoholic fatty liver disease (NAFLD). We also investigated whether MERTK is expressed in human hepatic stellate cells (HSC) and in murine models of fibrogenesis. Methods We considered 533 consecutive patients who underwent liver biopsy for suspected non-alcoholic steatohepatitis (NASH) without severe obesity from two …
Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential an…
2016
There are no approved treatments for liver fibrosis. To aid development of antifibrotic therapies, noninvasive biomarkers that can identify patients with progressive fibrosis and that permit monitoring of the response to antifibrotic therapy are much needed. Samples from a phase II antifibrotic trial of the glitazone farglitazar in patients with advanced hepatitis C, with matched follow-up liver biopsies, and from a phase III study of balaglitazone in patients with late-stage Type 2 diabetes (BALLET study) were analyzed for serological Pro-C3 levels in conjunction with other disease parameters. In the farglitazar study, a predefined cutoff value for Pro-C3 as a selection criterion led to t…