Search results for "Takifugu"

showing 3 items of 3 documents

Unusual genomic structure: melanocortin receptors in Fugu.

2005

The melanocortin (MC) receptors are found in five subtypes in mammals and chicken, while recent studies have shown that the Fugu (Takifugu rubripes) genome has only four MC receptors and the zebrafish genome has six subtypes. The MC3 receptor seems to be missing from the two closely related pufferfishes, Fugu and Tetraodon (Tetraodon nigroviridis). The MC2 and MC5 receptors in the pufferfish have introns. Moreover, these two receptors are found in a tandem that is remarkably conserved in several vertebrate species. Here, we speculate about the genomic origin of the MC receptors.

Geneticsmedicine.medical_specialtyGenomebiologyTakifugu rubripesFuguGeneral NeuroscienceReceptors MelanocortinfungiSequence Analysis DNATetraodon nigroviridisbiology.organism_classificationGeneral Biochemistry Genetics and Molecular BiologyMelanocortin 3 receptorTakifuguEndocrinologyHistory and Philosophy of ScienceInternal medicinemedicineAnimalsMelanocortinReceptorTetraodonG protein-coupled receptorAnnals of the New York Academy of Sciences
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Isolation and characterization of cold-shock domain protein genes, Oryzias latipes Y-box protein 2 ( OlaYP2 ) and Fugu rubripes Y-box protein 1 ( Fru…

2002

The Y-box protein (YP) family shares a nucleic acid binding domain, called cold-shock domain, that has been evolutionarily highly conserved from bacteria to human. The different YPs identified so far in vertebrates are thought to function as transcriptional activators, transcriptional repressors and/or translational repressors. Medakafish and pufferfish are very suitable vertebrate models for the study of developmental genetics and comparative genomics, respectively. Here we report the isolation of two teleost YP genes, medakafish Oryzias latipes (Ola)YP2 and Fugu rubripes (Fru)YP1, which are expressed in multiple tissues. Phylogenetic analysis demonstrated that OlaYP2 and FruYP1 belong to …

MaleDNA ComplementarySequence analysisOryziasMolecular Sequence DataProtein domainOryziasGene ExpressionBiologyGeneticsAnimalsAmino Acid SequenceIn Situ Hybridization FluorescencePhylogenyComparative genomicsGeneticsBase SequenceSequence Homology Amino AcidFugufungiChromosome MappingSequence Analysis DNAGeneral MedicineY box binding protein 1Cold-shock domainbiology.organism_classificationTakifuguFemaleSequence AlignmentTranscription FactorsBinding domainGene
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Agouti-Related Proteins (AGRPs) and Agouti-Signaling Peptide (ASIP) in Fish and Chicken

2005

We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C-terminal part of agouti-related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two from Fugu (Takifugu rubripes), and three from Tetraodon (Tetraodon nigroviridis). We have thus shown for the first time that both AGRP and ASIP genes exist in many species in "lower vertebrates" and were most probably present in early stages of vertebrate evolution.

Takifugu rubripesMolecular Sequence DataTetraodon nigroviridisGeneral Biochemistry Genetics and Molecular BiologySpecies SpecificityHistory and Philosophy of Sciencebiology.animalDatabases GeneticAnimalsAgouti-Related ProteinAmino Acid SequenceTetraodonGeneZebrafishPeptide sequencePhylogenyGeneticsbiologyFuguGeneral Neurosciencedigestive oral and skin physiologyFishesProteinsVertebratebiology.organism_classificationAgouti Signaling ProteinIntercellular Signaling Peptides and ProteinsChickensAnnals of the New York Academy of Sciences
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