Search results for "Tandem"
showing 10 items of 560 documents
In-situ synthesis of hydrogen peroxide in tandem with selective oxidation reactions: A mini-review
2014
7 Figuras, 6 Tablas
Dimethyl 2-(1-methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate
2020
In this work we report a facile access to a 3,3-disubstituted isobenzofuranone by tandem addition/cyclization reaction to methyl 2-acetylbenzoate in the presence of dimethyl malonate, under basic conditions.
Luokkatandemilla vauhtia ammattikorkeakoulun toisen kotimaisen kielen opiskeluun
2014
Artikkeli kertoo Insinööriopiskelijoiden korkeakoulutandem -hankkeesta, jossa Vaasan ammattikorkeakoulun ja Yrkeshögskolan Novian insinööriopiskelijat harjoittelivat yhdessä suomea/ruotsia toisen kotimaisen kielen opintojakson puitteissa. Menetelmäksi valittiin luokkatandem. Tavoitteena oli, että opiskelijat saisivat harjoitella ennen kaikkea suullista kielitaitoa mielekkäiden tehtävien parissa sosiaalisessa vuorovaikutuksessa. Sekä opettajien että opiskelijoiden kokemukset olivat erittäin myönteisiä ja kannustavat jatkamaan luokkatandemin käyttöä jatkossakin toisen kotimaisen kielen opetuksessa. nonPeerReviewed
Klasstandem i en tvåspråkig skolkontext
2013
I denna artikel diskuterar vi erfarenheter av ett pågående forsknings- och utvecklingsprojekt, kallat Klasstandem. Syftet med projektet är att på empirisk grund utveckla språkpedagogiska modeller för språkligt blandade elevgrupper inom undervisningen i det andra inhemska språket. Julkaistu versio/Published PDF nonPeerReviewed
A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-M…
2016
An analytical method for simultaneous determination of seven commonly used antibiotics and three antiretrovirals in surface water and urban wastewater at the ng L−1 level has been developed. The method involves concentration and clean-up by solid phase extraction (SPE) followed by identification and quantification by liquid chromatography tandem mass spectrometry (LC-ESI-MS/MS). The use of matrix-matched calibration curves constructed by spiking surface water was evaluated for quantification and compared with the internal standard method using isotopically labelled compounds. The method gave absolute recoveries of 41–116% with most of the compounds having recoveries >50%. The LOQs ranged fr…
Data from: Characterization of recruitment through tandem running in an Indian queenless ant Diacamma indicum
2017
Tandem running is a primitive recruitment method employed by many ant genera. This study characterizes this behaviour during the recruitment of colony mates to a new nest in an Indian ant Diacamma indicum. Tandem leaders who have knowledge of the new nest lead a single follower at a time, to the destination by maintaining physical contact. In order to characterize tandem running, we captured and analysed 621 invitations, 217 paths and 226 termination events. Remarkably, not a single colony member was lost. While invitations were stereotypic in behaviour, termination was not. Analysis of speed revealed that the average transport speed was 4.2 cm s−1. Coupled adult-brood transport was slower …
Rationally designed haptens for highly sensitive monoclonal antibody-based immunoanalysis of fenhexamid.
2018
Immunochemical methods have been consolidated during the last few years as complementary analytical strategies for chemical contaminant and residue determination. However, generation of suitable immunoreagents for small organic molecules demands adequate hapten design. In this study, fenhexamid was considered as a model compound and novel haptens were designed and synthesized in order to evaluate the influence of the linker tethering site on antibody binding properties and immunoassay parameters. Haptens were conceived with the spacer arm at different positions, while the more antigenic aromatic moiety was kept free. The synthesis of these functionalized compounds was accomplished by total …
Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation
2014
Background & Aims Recurrence of hepatitis C virus (HCV) infection after orthotopical liver transplantation (OLT) is common and associated with reduced graft and patient survival. The protease inhibitor telaprevir may enhance virological response rates in patients after OLT in combination with pegylated interferon-alfa and ribavirin. Pharmacokinetic studies have shown significant drug–drug interactions between telaprevir and immunosuppression (IS), but telaprevir pharmacokinetics in OLT patients with IS are unknown. Aim of the present study was to analyse telaprevir plasma concentrations in patients with HCV genotype 1 infection after OLT in comparison to patients without OLT and IS. Methods…
Newborn screening of inherited metabolic disorders by tandem mass spectrometry: past, present and future
2013
Inborn errors of metabolism are inherited biochemical disorders caused by lack of a functional enzyme, transmembrane transporter, or similar protein, which then results in blockage of the corresponding metabolic pathway. Taken individually, inborn errors of metabolism are rare. However, as a group these diseases are relatively frequent and they may account for most of neonatal mortality and need of health resources. The detection of genetic metabolic disorders should occur in a pre-symptomatic phase. Recently, the introduction of the tandem mass spectrometric methods for metabolite analysis has changed our ability to detect intermediates of metabolism in smaller samples and provides the mea…
Metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia.
2013
Hypoxic-ischemic insults to the neonatal brain may cause neurodevelopmental disorders. Vulnerability of different areas of the neural tissue to hypoxic-ischemic stress might be explained by either heterogeneous sensitivity to oxygen or neuroprotective capability. Our understanding of regional heterogeneity is still incomplete in terms of metabolic reconfiguration and/or activation of neuroprotective mechanisms.We studied, by western blotting, reverse-transcriptase PCR, and tandem mass spectrometry, the response of retina and choroid at protein, gene, and metabolic levels during hypoxia in a piglet model of acute postnatal hypoxia.We evidenced a metabolic shift towards glycolysis in choroid …