Search results for "Terminology"
showing 10 items of 307 documents
Professionals' naming of intellectual disability, past and present practice and rationales
2011
The study illuminates four research questions: What terms for the diagnosis ICD10: F70-79 do Norwegian professionals utilize in their work? Which changes of terminology have professionals experienced? How do professionals explain such changes? Is there a substantive explanation? A semi-structured qualitative interview guide was used on a sample of 41 informants. The main findings are: (1) Different terms are in use; (2) two major changes in naming are observed by the informants: (a) during the 1970s from ‘feeble-minded’ to ‘mental developmental disability’, and (b) after year 2000 from ‘mental developmental disability’ to ‘developmental disability’; (3) professionals are in doubt as to whic…
Neuropathic pain. Redefinition and a grading system for clinical and research purposes.
2008
Pain usually results from activation of nociceptive afferents by actually or potentially tissue-damaging stimuli. Pain may also arise by activity generated within the nervous system without adequate stimulation of its peripheral sensory endings. For this type of pain, the International Association for the Study of Pain introduced the term neuropathic pain, defined as "pain initiated or caused by a primary lesion or dysfunction in the nervous system." While this definition has been useful in distinguishing some characteristics of neuropathic and nociceptive types of pain, it lacks defined boundaries. Since the sensitivity of the nociceptive system is modulated by its adequate activation (e.g…
Why DSM-III was right to introduce the concept of somatoform disorders.
2005
From the Psychological Institute, University of Mainz; and the Psychological Institute, University of Marburg, Marburg, Germany. Address correspondence and reprint requests to Dr. Hiller, Psychological Institute, University of Mainz, Staudingerweg 9, D-55099 Mainz, Germany; hiller@mail.uni-mainz.de (e-mail). Copyright 2005 The Academy of Psychosomatic Medicine. An interesting debate about the adequacy of the somatoform disorders as a diagnostic and clinical concept has begun. The debate is stimulated by the announcement of APA’s preparation of DSM-V, which is likely to follow DSM-IV as the world’s most influential classification system for defining the terminology and diagnostic definitions…
A comparison between industrial experts' and novices' haptic perceptual organization: a tool to identify descriptors of the handle of fabrics
2004
Abstract In descriptive analysis, the establishing of the list of attributes is crucial. Attributes should account for consumers' perceptions and be understood by professionals for efficient communication. This work was aimed at identifying the most appropriate attributes for fabric description from the terminology associated with both experts' and novices' haptic perceptual spaces. Eleven industrial experts and two groups of novices (20 males and 20 females) evaluated 26 clothing fabrics. They performed (1) a free-sorting task based on haptic similarities, (2) a description of the previously formed groups, and (3) a hedonic rating task for each fabric. The perceptual organization was simil…
Au cœur de la terminologie du jeu vidéo. L’absence de ressources, frein majeur pour les traducteurs
2021
Technologies et gestion terminologique : une etude aupres des utilisateurs L’industrie videoludique est un secteur d’activite dont la croissance n’a cesse de s’amplifier tant sur le plan economique que du point de vue professionnel depuis sa naissance dans les annees 1970. Une etude publiee sur le site specialise Newzoo.com devoile que le chiffre d’affaires du secteur a atteint les 174,9 milliards de dollars en 2020, depassant ainsi, une fois de plus, celui de l’industrie cinematographique. A...
Organization of the ophidian amygdala: chemosensory pathways to the hypothalamus.
1999
Although recent studies in squamate reptiles have importantly clarified how chemical information is processed in the reptilian brain, how the amygdala relays chemosensory inputs to the hypothalamus to influence chemically guided behaviors is still poorly documented. To identify these chemosensory pathways, the amygdalo-hypothalamic projections, intra-amygdaloid circuitry and afferents from the lateral cortex (LC) to the amygdala were investigated by injecting conjugated dextran-amines into the hypothalamus, amygdala, and LC of garter snakes. The amygdala was divided into olfactory recipient (ventral anterior and external amygdalae), vomeronasal recipient (nucleus sphericus, NS, and medial a…
Efficacy of nivolumab in pre-treated non-small-cell lung cancer patients harbouring KRAS mutations
2018
Background: The present study investigated the efficacy and safety of nivolumab in pre-treated patients with advanced NSCLC harbouring KRAS mutations. Methods: Clinical data and KRAS mutational status were analysed in patients treated with nivolumab within the Italian Expanded Access Program. Objective response rate, progression-free survival and overall survival were evaluated. Patients were monitored for adverse events using the National Cancer Institute Common Terminology Criteria for Adverse Events. Results: Among 530 patients evaluated for KRAS mutations, 206 (39%) were positive while 324 (61%) were KRAS wild-type mutations. KRAS status did not influence nivolumab efficacy in terms of …
70 Patient reported outcome in platinum-resistant recurrent ovarian cancer and metastatic breast cancer treated with metronomic chemotherapy
2021
Introduction/Background* In the treatment of both platinum-resistant recurrent ovarian cancer (ROC) and metastatic breast cancer (MBC), symptom control and maintenance of quality of life (QoL) play a crucial role. In the advanced stage of disease, metronomic chemotherapy (MCT) may be a favourable treatment option. The aim of this study is to assess the QoL of heavily pretreated patients with ROC and MBC treated with MCT. Methodology PROmetronomic, FoR.UM 19-02193, is a monocentric, open-label, single-arm observational study to assess health-related patient-reported outcome data in ROC and MBC patients treated with MCT (cyclophosphamide 50 mg p.o. daily ± methotrexate 2.5 mg p.o. every other…
Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodie…
2021
Background: Metastatic colorectal cancer (mCRC) with wild type expression of RAS and RAF genes can be treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, such as cetuximab, in combination with chemotherapy. Skin toxicity represents the most serious and frequent side effect in these patients. Skin manifestations occur in approximately 80% of patients. In this study, we investigated the consequences on body image and quality of life (QoL) of patients with severe skin toxicity. Methods: One hundred patients were enrolled with mCRC. All patients signed informed consent and completed questionnaires to assess QoL and body discomfort. Toxicity was assessed on Common Te…
Precision Medicine in Oncology: Glossary of Relevant Scientific Terms
2021
The conventional oncological approach was defined in the past as “one size fits all” and the tumors were treated according to the localization and the histopathological features. One of the future challenges in the field of oncology is the integration of translational research and technology innovation, in order to clarify unexplored aspects of the biology and the genetics of tumors, to develop a personalized treatment based on the molecular characteristics of the patient and his disease, that is the principle of precision medicine. New multidisciplinary teams are needed to ensure the integration of different professional profiles, including oncologists, pharmacologists, geneticians, and pa…