Search results for "Thermophoresis"
showing 10 items of 22 documents
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
2021
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (GRP78). We aimed for a better understanding of the neuroprotective mechanisms of MANF. Here we show for the first time that MANF promotes the survival of …
Molecular docking-based virtual drug screening revealing an oxofluorenyl benzamide and a bromonaphthalene sulfonamido hydroxybenzoic acid as HDAC6 in…
2020
HDAC6 is a crucial epigenetic modifier that plays a vital role in tumor progression and carcinogenesis due to its multiple biological functions. It is a unique member of class-II HDAC enzymes. It possesses two catalytic domains, which function independently of the overall enzyme activity. Up to date, there are only a few selective HDAC6 inhibitors with anti-cancer activity. In this study, 175,204 ligands obtained from the ZINC15 and OTAVAchemical databases were used for virtual drug screening against HDAC6. Molecular docking studies were performed for 100 selected compounds. Furthermore, the top 10 compounds obtained from docking were tested for their efficacy to inhibit the function of HDA…
A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening
2018
Graphical abstract
New transport properties of ferrocolloids: magnetic Soret effect and thermomagnetoosmosis
2005
The paper deals with critical analysis of experiments on thermodiffusion in ferrocolloids. The observed magnetic Soret effect is significantly stronger than that predicted theoretically. It is shown that the main reason for that is the influence of a magnetic field on mass diffusion. Besides, some measurements are effected by uncontrolled thermal and solutal magnetic convection. Even in porous media, when macroscopic convection is depressed, thermodiffusion can be disturbed by microconvective mass transfer induced by particle magnetophoresis on filter grains.
Heat and mass transfer phenomena in magnetic fluids
2007
In this article the influence of a magnetic field on heat and mass transport phenomena in magnetic fluids (ferrofluids) will be discussed. The first section is dealing with a magnetically driven convection, the so called thermomagnetic convection while in the second section the influence of a temperature gradient on the mass transport, the Soret effect in ferrofluids, is reviewed. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Soret Effect In Forced Rayleigh-scattering
1987
In forced Rayleigh scattering of mixtures or suspensions the temperature gratings generate, by the Soret effect, concentration gratings that may be very important since they produce both a phase and an amplitude grating superimposed on the principal one. The experimental evidence of their influence was given by Thyagarajan and Lallemand using a mixture of carbondisulfide and ethanol. In this paper we study the temporal behaviour of the concentration grating versus the sample properties and its effect on the detected diffracted beam. Explicit expressions are given for the output intensity taking into account both the generated amplitude and phase gratings.
Mass transfer in nonisothermal ferrocolloids under the effect of a magnetic field
1999
Abstract The paper presents a review of newest experimental results on particle thermal diffusion in hydrocarbon based ferrofluids. The measurements are performed using a vertical thermal diffusion column, the Soret coefficient is evaluated from particle separation curves employing a simple column theory which accounts for thermal convection in the vertical channel forced by a concentration buoyancy force arising during the thermophoretic transfer of heavy particles. High positive values of the Soret coefficient of lyophilized Fe 3 O 4 and Mn x Zn 1− x Fe 2 O 4 particles in surfacted tetradecane based colloids are measured. Experiments confirm the theoretically predicted anisotropy of parti…
Non-isothermal mass transfer of ferrocolloids through porous membrane
2011
Abstract The present paper deals with transport properties of ferrofluid nanoparticles in non-isothermal capillary-porous layer. Experiment establishes that the temperature difference, which is applied across the layer, induces a thermoosmotic pressure gradient directed toward increasing temperature. The measurement results are interpreted in a frame of phenomenology of linear irreversible thermodynamics. The transport coefficients are evaluated comparing the measured separation curves with approximate solution of the corresponding mass transfer problem.
Thermophoretic separation of ultrafine particles in ferrofluids in thermal diffusion column under the effect of an MHD convection
2000
The aim of the paper is to evaluate the Soret coeAcient ST of colloidal particles in ferrofluids from measurements of an unsteady particle separation in a flat thermodiAusion column. The column theory is modified taking into account MHD eAects of thermal convection aAected by a concentration buoyancy force. It is shown that the Hartmann eAect, not only in hydrocarbon based colloids but also in ionic magnetic fluids of relatively high electric conductivity, does not influence significantly the particle separation dynamics. From measurements, positive values of ST of surfacted particles in tetradecane based colloids are calculated. An anisotropy of the Soret eAect in the presence of a uniform…
Determination of the Soret coefficient of magnetic particles in a ferrofluid from the steady and unsteady part of the separation curve
2004
Experiments on the particle separation in a vertical thermodiffusion column are used to investigate the separation (Soret effect) in ferrofluids. The use of a two-sectional column with internal walls of low thermal capacity allows analyzing the initial part of the unsteady separation curves as well as the steady state regime. The Soret coefficient calculated from the measurements of the separation dynamics agrees well with the one found from the steady separation limit reached in long-time experiments especially if the solutal buoyancy is low.