Search results for "Thiol"
showing 10 items of 485 documents
THIOPYRANO[2,3-E]INDOL-2-ONES: ANGELICIN HETEROANALOGUES WITH POTENT PHOTOANTIPROLIFERATIVE ACTIVITY
2008
A new class of compounds, the thiopyrano[2,3-e]indol-2-ones, bioisosters of the angular furocoumarin angelicin, was synthesized with the aim of obtaining new photochemotherapeutic agents. In particular 7,8-dimethyl-thiopyranoindolone 6c s showed a remarkable phototoxicity and a great dose UVA dependence reaching IC(50) values at submicromolar level. This latter photoinduced a massive apoptosis and a remarkable photodamage to lipids and proteins. Although it did not intercalate DNA, it was able to cause photooxidation of DNA bases.
The effect of tether groups on the spin states of iron(ii)/bis[2,6-di(pyrazol-1-yl)pyridine] complexes
2021
The synthesis of six 2,6-di(pyrazol-1-yl)pyridine derivatives bearing dithiolane or carboxylic acid tether groups is described: [2,6-di(pyrazol-1-yl)pyrid-4-yl]methyl (R)-lipoate (L1), 2-[(2,6-di(pyrazol-1-yl)pyridine)-4-carboxamido]ethyl (R)-lipoate (L2), 2-[(2,6-di(pyrazol-1-yl)pyridine)-4-carboxy]ethyl (R)-lipoate (L3), N-([2,6-di(pyrazol-1-yl)pyrid-4-ylsulfanyl]-2-aminoethyl (R)-lipoamide (L4), 2-[(2,6-di(pyrazol-1-yl)pyridine)-4-carboxamido]acetic acid (L5) and 2-[(2,6-di(pyrazol-1-yl)pyridine)-4-carboxamido]propionic acid (L6). The iron(ii) perchlorate complexes of all the new ligands exhibit gradual thermal spin-crossover (SCO) in the solid state above room temperature, except L4 who…
Phosphororganische Verbindungen, 111. Phosphin‐ und Thiophosphinsäure‐cyanide als fluoreszierende SH‐selektive Reagenzien
1985
Die fluoreszierenden Thiophosphinsaure-cyanide 7 und 8 sind SH-selektive, die analogen Thio-phosphinsaure-chloride 5 und 6 sind im allgemeinen NH2-selektiv (Ausnahme: Cystein-methylester, der S-thiophosphinoyliert wird). Die auf diesem Wege erhaltenen fluoreszierenden Dithio-phosphinsaureester, z.B. 11–14, sind fur die Analyse interessant. Durch Fluorolyse der Dithio-phosphinsaureester konnen die Thiole regeneriert werden. Diphenylthiophosphinsaure-cyanid verdient als SH-selektive Schutzgruppe fur Synthesen den Vorzug vor 7 und 8. Organophosphorus Compounds, 111 Phosphinic and Thiophosphinic Cyanides as Fluorescent SH-selective Reagents The fluorescent thiophosphinic cyanides 7 and 8 are SH…
Preparation and study of silver maleonitriledithiolate complexes
1985
Abstract This paper reports the reaction of Ag2(mnt) and [(NEt4)Ag(mnt)] (mnt2− = maleonitriledithiolate) with PPh3 and 1,2-bis(diphenylphosph
Sequestering ability of some chelating agents towards methylmercury(II).
2013
A study on the interactions between CH3Hg+ and some S, N and O donor ligands (2-mercaptopropanoic acid (thiolactic acid (H2 TLA)), 3-mercaptopropanoic acid (H2 MPA), 2-mercaptosuccinic acid (thiomalic acid (H3 TMA)), d,l-penicillamine (H2 PSH), l-cysteine (H2 CYS), glutathione (H3 GSH), N,N′-bis(3-aminopropyl)-1-4-diaminobutane (spermine (SPER)), 1,2,3,4,5,6-benzenehexacarboxylic acid (mellitic acid (H6 MLT)) and ethylenediaminetetraacetic acid (H4 EDTA)) is reported. The speciation models in aqueous solution and the possible structures of the complexes formed are discussed on the basis of potentiometric, calorimetric, UV spectrophotometric and electrospray mass spectrometric results. For t…
Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups
2009
International audience; The functionalization of superparamagnetic iron oxide nanoparticles (SPIOs) by meso-2,3-dimercaptosuccinic acid (DMSA) was investigated. Under ambient conditions, the thiol groups from DMSA are not stable and do not allow a direct functionalization without storage in stringent conditions or a chemical regeneration of free thiols. In this study, we have developed a protocol based on poly(ethylene glycol) (PEG) grafting of SPIO prior to DMSA anchoring. We have observed that PEG helps to increase the stability of thiol groups under ambient conditions. The thiol functionalized SPIOs were stable under physiological pH and ionic strength as determined by Ellman's essay and…
Oxygen atom transfer reaction involving oxomolybdenum complexes with sterically bulky thiocarboxylate ligands and biochemical interesting substrates …
1999
Abstract Oxidation–reduction reactions of substrates in systems containing the complex [Mo VI O 2 (O 2 CC(S)CH 3 Ph) 2 ] 2− in methanol have been investigated as models of oxo-transfer reactions. At neutral pH, the [Mo VI O 2 (O 2 CC(S)CH 3 Ph) 2 ] 2− reacts with Me 2 PhP or n -butanethiol to yield a [Mo IV O(O 2 CC(S)CH 3 Ph) 2 ] 2− species and Me 2 PhPO or disulfide, respectively. The Mo IV O complex reduces a variety of substrates XO = Me 2 SO and pyridine N-oxide conducing formation of X = Me 2 S and pyridine. The occurrence of these reactions produces a catalytic system Me 2 PhP + XO → Me 2 PhPO + X and 2BuSH + XO → [BuS] 2 + X + H 2 O. In this work we have also included the study of …
CCDC 235538: Experimental Crystal Structure Determination
2004
Related Article: J.Vicente, J.-A.Abad, F.S.Hernandez-Mata, B.Rink, P.G.Jones, M.C.R.de Arellano|2004|Organometallics|23|1292|doi:10.1021/om0342964
Reduced Apo-Fumarate Nitrate Reductase Regulator (ApoFNR) as the Major Form of FNR in Aerobically Growing Escherichia coli▿
2008
ABSTRACT Under anoxic conditions, the Escherichia coli oxygen sensor FNR (fumarate nitrate reductase regulator) is in the active state and contains a [4Fe-4S] cluster. Oxygen converts [4Fe-4S]FNR to inactive [2Fe-2S]FNR. After prolonged exposure to air in vitro, apoFNR lacking a Fe-S cluster is formed. ApoFNR can be differentiated from Fe-S-containing forms by the accessibility of the five Cys thiol residues, four of which serve as ligands for the Fe-S cluster. The presence of apoFNR in aerobically and anaerobically grown E. coli was analyzed in situ using thiol reagents. In anaerobically and aerobically grown cells, the membrane-permeable monobromobimane labeled one to two and four Cys res…
Formation Kinetics of Mixed Self-Assembled Monolayers of Alkanethiols on GaAs(100)
2017
International audience; We report on the formation kinetics of mixed self-assembled monolayers (SAMs) comprising 16-mercaptohexadecanoic acid (MHDA) and 11-mercapto-1-undecanol (MUDO) thiols on GaAs(100) substrates. These compounds were selected for their potential in constructing highly selective and efficient architectures for biosensing applications. The molecular composition and quality of one-compound and mixed SAMs were determined by the Fourier transform infrared absorption spectroscopy measurements. The formation of enhanced-quality mixed SAMs was investigated as a function of the molecular composition of the thiol mixture and the proportion of ethanol/water solvent used during thei…