Search results for "Time"

The IceCube data acquisition system: Signal capture, digitization, and timestamping

2008

IceCube is a km-scale neutrino observatory under construction at the South Pole with sensors both in the deep ice (InIce) and on the surface (IceTop). The sensors, called Digital Optical Modules (DOMs), detect, digitize and timestamp the signals from optical Cherenkov-radiation photons. The DOM Main Board (MB) data acquisition subsystem is connected to the central DAQ in the IceCube Laboratory (ICL) by a single twisted copper wire-pair and transmits packetized data on demand. Time calibration is maintained throughout the array by regular transmission to the DOMs of precisely timed analog signals, synchronized to a central GPS-disciplined clock. The design goals and consequent features, func…

On the carrier of inertia

2018

A change in momentum will inevitably perturb the all-embracing vacuum, whose reaction we understand as inertia. Since the vacuum's physical properties relate to light, we propose that the vacuum embodies photons, but in pairs without net electromagnetic fields. In this physical form the free space houses energy in balance with the energy of matter in the whole Universe. Likewise, we reason that a local gravitational potential is the vacuum in a local balance with energy that is bound to a body. Since a body couples to the same vacuum universally and locally, we understand that inertial and gravitational masses are identical. By the same token, we infer that gravity and electromagnetism shar…

MODELLI IDROECONOMICI E ANALISI DEGLI INVESTIMENTI NEL SETTORE DELL' APPROVVIGIONAMENTO PRIMARIO

2011

Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Moll…

2011

Since sponges, as typical filter-feeders, are exposed to a high load of attacking prokaryotic and eukaryotic organisms, they are armed with a wide arsenal of antimicrobial/cytostatic low-molecular-weight, non-proteinaceous bioactive compounds. Here we present the first sponge agent belonging to the group of ASABF-type antimicrobial peptides. The ASABF gene was identified and cloned from the demospongeSuberites domuncula. The mature peptide, with a length of 64 aa residues has a predicted pI of 9.24, and comprises the characteristic CSαβ structural motif. Consequently, the S. domuncula ASABF shares high similarity with the nematode ASABFs ; it is distantly related to the defensins. The recom…

Search for neutrino emission from gamma-ray flaring blazars with the ANTARES telescope

2012

The ANTARES telescope observes a full hemisphere of the sky all the time with a duty cycle close to 100%. This makes it well suited for an extensive observation of neutrinos produced in astrophysical transient sources. In the surrounding medium of blazars, i.e. active galactic nuclei with their jets pointing almost directly towards the observer, neutrinos may be produced together with gamma-rays by hadronic interactions, so a strong correlation between neutrinos and gamma-rays emissions is expected. The time variability information of the studied source can be obtained by the gamma-ray light curves measured by the LAT instrument on-board the Fermi satellite. If the expected neutrino flux ob…

Selective downregulation of the MDR1 gene product in Caco-2 cells by stable transfection to prove its relevance in secretory drug transport.

2005

Considerable interest is focused on overcoming multidrug resistance (MDR) in cancer chemotherapy. The in vitro experiments to characterize P-glycoprotein's (P-gp) function and to decrease its effects have led to a variety of strategies such as addition of competitors or supplementation of the medium with oligonucleotides complementary to the 5'-end of the MDR1-mRNA. For the Caco-2 cell line, an in vitro model for absorption screening, expressing multiple transporters including P-gp, which pumps substances back into the apical solution, P-gp activity might mask other relevant transport proteins' activity. The objective of the present study was to construct a Caco-2 subline with reduced P-gp …

Audiovisual time-to-collision estimation for accelerating vehicles: The acoustic signature of electric vehicles impairs pedestrians' judgments

2022

To avoid collisions, pedestrians intending to cross a road need to accurately estimate the time-to-collision (TTC) of an approaching vehicle. For TTC estimation, auditory information can be considered particularly relevant when the approaching vehicle accelerates. The sound of vehicles with internal combustion engine (ICEVs) provides characteristic auditory information about the acceleration state (increasing speed and engine load). However, for electric vehicles (EVs), the acoustic signature during acceleration is less salient. Although the auditory detection of EVs has been studied extensively, there is no research on potential effects of the altered acoustic signature of EVs on TTC estim…

Quantification of LAI interannual anomalies by adjusting climatological patterns

2011

International audience; Scaling variations and shifts in the timing of seasonal phenology are central features of global change research. In this study, we propose a novel climatology fitting approach to quantify inter-annual anomalies in LAI seasonality. A consistent archive of daily LAI estimates was first derived from historical AVHRR satellite data for the 1981-2000 period over a globally representative sample of sites. The climatology values were then computed by averaging multi-year LAI profiles, gap filling and smoothing to eliminate possible high temporal frequency residual artifacts. The inter-annual variations in LAI were finally quantified by scaling and shifting the seasonal cli…

La réussite en éducation musicale : des facteurs individuels aux facteurs contextuels

2007

This study aim to improve knowledge about individual and contextual factors of success in music education during elementary level's first year. There are three main subjects : acquisitions' social inequalities, teacher-effect and children' interest about in class musical activities. Two musical tests (one at the beginning of the year, another at the end) were administrated to 1184 students living in Burgondy. Questionnaries completed by various actors (teachers and students) gave a lot of data. Data were analysed with multivariate models. Our results demonstrated that 1°) musical practices develop abilities and explain social origin's effect on musical acquisitions at the beginning of the y…

Centri minori fra modelli nuovi o ritrovati. Le alte Madonie tra opportunità e suggestioni

2022

«Un’architettura basata sulla complessità e sulla contraddizione richiede un impegno speciale verso l’insieme: la sua reale validità deve essere nella sua totalità, o nelle sue implicazioni di totalità» afferma Robert Venturi (Venturi, 2005, p. 16). Questo suggerimento è ancora essenziale per tutti coloro che intendono affrontare da vicino il ruolo del progetto nel territorio dei Centri minori? Sigfried Giedion, nel suo Space, Time and Architecture leggeva l’edificio per l’abitante della città. Aveva voglia di «godersi il panorama, le brezze ed il sole, godere in tutta calma quella naturale libertà di cui il suo lavoro lo privava» (Giedion, 1953, p. 505). A distanza di molti anni, il nostro…