Search results for "Timo"
showing 10 items of 2111 documents
Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a pa…
2020
Summary The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 is a global public health crisis. Multiple observations indicate poorer post-infection outcomes for patients with cancer than for the general population. Herein, we highlight the challenges in caring for patients with acute leukaemias and myeloid neoplasms amid the COVID-19 pandemic. We summarise key changes related to service allocation, clinical and supportive care, clinical trial participation, and ethical considerations regarding the use of lifesaving measures for these patients. We recognise that these recommendations might be more applicable to high-income countries and might not be general…
Effective Management of Severe Asthma with Biologic Medications in Adult Patients: A Literature Review and International Expert Opinion
2021
International audience; Severe asthma often remains uncontrolled despite effective treatments and evidence-based guidelines. A group of global experts in asthma and biologic medications from nine countries considered the most relevant clinical variables to manage severe asthma in adult patients and guide treatment choice. The resulting recommendations address the investigation of biomarker levels (blood eosinophil count along with fractional concentration of exhaled nitric oxide [FeNO]), clinical features (oral corticosteroid [OCS] dependency, specific comorbid disease entities associated with severe type 2 asthma), and safety considerations. Current evidence suggests that biomarkers, inclu…
Multimorbidity and polypharmacy in the elderly: Lessons from REPOSI
2014
none 10 no The dramatic demographic changes that are occurring in the third millennium are modifying the mission of generalist professionals such as primary care physicians and internists. Multiple chronic diseases and the related prescription of multiple medications are becoming typical problems and present many challenges. Unfortunately, the available evidence regarding the efficacy of medications has been generated by clinical trials involving patients completely different from those currently admitted to internal medicine: much younger, affected by a single disease and managed in a highly controlled research environment. Because only registries can provide information on drug effectiven…
Physical Multimorbidity and Sarcopenia among Adults Aged ≥65 Years in Low- and Middle-Income Countries.
2022
<b><i>Introduction:</i></b> Physical multimorbidity is plausibly linked to sarcopenia. However, to date, only a few studies exist on this topic, and none have examined this association in low- and middle-income countries (LMICs). Thus, we aimed to investigate the association between multimorbidity and sarcopenia in a sample of older adults from six LMICs (China, Ghana, India, Mexico, Russia, South Africa). <b><i>Methods:</i></b> Cross-sectional, community-based data from the WHO Study on Global Ageing and Adult Health (SAGE) were analysed. Sarcopenia was defined as having low skeletal muscle mass (SMM) and weak handgrip strength, while severe …
Multimorbidity increases the risk of dementia: a 15 year follow-up of the SHARE study.
2023
Abstract Aims the literature regarding the association between multimorbidity and dementia is still unclear. Therefore, we aimed to explore the potential association between multimorbidity at the baseline and the risk of future dementia in the SHARE (Survey of Health, Ageing and Retirement in Europe) study, a large European research survey, with a follow-up of 15 years. Methods in this longitudinal study, multimorbidity was defined as the presence of two or more chronic medical conditions, among 14 self-reported at the baseline evaluation. Incident dementia was ascertained using self-reported information. Cox regression analysis, adjusted for potential confounders, was run and hazard ratios…
Longitudinal Study on Sustained Attention to Response Task (SART): Clustering Approach for Mobility and Cognitive Decline
2022
The Sustained Attention to Response Task (SART) is a computer-based go/no-go task to measure neurocognitive function in older adults. However, simplified average features of this complex dataset lead to loss of primary information and fail to express associations between test performance and clinically meaningful outcomes. Here, we combine a novel method to visualise individual trial (raw) information obtained from the SART test in a large population-based study of ageing in Ireland and an automatic clustering technique. We employed a thresholding method, based on the individual trial number of mistakes, to identify poorer SART performances and a fuzzy clusters algorithm to partition the da…
Determinants of Italian agri-food exports in non-EU Mediterranean Partner Countries: An empirical investigation through a gravity model approach
2013
The aim of this paper is to lay emphasis on the main factors (economic, historical, structural, etc.) that affect Italian agri-food exports in the non-EU Mediterranean Partner Countries (MPCs). The authors estimate a gravity equation including some of the main variables found in the reference literature useful to highlight the main factors which influence the bilateral exchanges. The results show that the variables traditionally included in the gravity equation present the expected sign. In particular, Italian agri-food exports towards its neighbouring Mediterranean countries are positively affected by income of partner countries, colonial and historical ties, geographical proximity and the…
THE ROLE OF SICILY IN THE MARITIME TRAFFIC OF AGRI-FOOD PRODUCTS IN THE MEDITERRANEAN BASIN
2011
This paper shows the results of a survey on trade flows to agri-food products among Sicily and the non-EU countries of the Union for the Mediterranean, through maritime transport. The aim of this paper is to outline the role that Sicily plays in respect of trade in agricultural products through the maritime mode considering its strategic location in the Mediterranean basin. Political reference scenario is that of the Union for the Mediterranean and EU Mediterranean Transport Policy (motorways of the sea). The work contains an analysis of the evolution of maritime trade in agri-food of Sicily, in the main ports of departure and arrival, with non-EU countries of the Union for the Mediterranea…
Agricoltura, alimentazione e paesaggio nei territori produttivi. Intrecci disciplinari tra piano e programmi di sviluppo nei casi della Sicilia centr…
2015
La riflessione che di seguito si sviluppa vuole condurre verso una più estesa considerazione delle implicazioni sociali dell’attività agricola. Il dibattito nel campo economico agrario, infatti, si concentra sui contenuti che l’attività agricola trasmette attraverso la modellazione del paesaggio, la conservazione della storia, la tutela dell’ambiente e della salute. La notorietà della Dieta mediterranea e il suo riconoscimento globale sembrano riassumere in larga parte queste proposizioni.
STRATEGY TO INCREASE THE FARM COMPETITIVENESS
2014
Italy’s wine-growing production structure is highly pulverized. So, for many wine-growing farms loweri ng the production cost represents the only way of gain ing a competitive advantage. Production at average unit costs lower than competitors allows to improve prof itability. Among farming operations, winter pruning and tying of productive vine-branches require a high hu man labor. For this reason the paper presents the r esults of research conducted on a sample of Sicilian wine- producing farms in order to study the cost-effectiv eness to make the pruning and the subsequent ligation of productive branches with tools that facilitate the work. The economic analysis, after the determination o…