Search results for "Transform"
showing 10 items of 3975 documents
A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: Developmental studies and molecular localization of the gene
1993
The recessive-lethal, temperature-sensitive (ts) mutation of the tumor suppressor gene lethal(3)malignant brain tumor (l(3)mbt) causes in a single step the malignant transformation of the adult optic neuroblasts and ganglion mother cells in the larval brain at the restrictive temperature of 29 degrees C. The transformed cells are differentiation-incompetent and grow autonomously in a lethal and invasive fashion in situ in the brain as well as after transplantation in vivo into wild-type adult hosts. The imaginal discs show epithelial overgrowth. At the permissive temperature of 22 degrees C development is completely normal. The ts-period of gene activity responsible for 100% brain tumor sup…
Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
2014
The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stemcells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cel…
Management of Distribution Risks and Digital Transformation of Insurance Distribution—A Regulatory Gap in the IDD
2021
The Insurance Distribution Directive (IDD) aims to regulate insurance distribution in the EU regardless of distribution channels and means. Although new technologies affect insurance distribution, the IDD does not explicitly regulate this digital transformation. Insurers and intermediaries must comply with detailed business conduct rules that aim to counteract distribution risks. However, the IDD exempts ancillary insurance intermediaries from its scope when they meet certain conditions. The article highlights the regulatory framework on insurance, requiring insurers and intermediaries to address distribution risks, and analyses how this exemption affects the management of distribution risk…
TGF-beta as a T cell regulator in colitis and colon cancer
2005
TGF-beta is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient for TGF-beta1 show a dramatic phenotype with severe multiorgan inflammation and die shortly after birth. Recent investigations have highlighted the role of TGF-beta in suppression of T cell mediated autoimmune inflammation and anti-tumor immunity. In addition to its direct anti-inflammatory effects on T cells, TGF-beta has been implicated as central regulator of regulatory T cells. TGF-beta not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-beta along with TCR stimulation in the peripheral induction of regulatory T cells from naïve CD4+CD25- c…
Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-beta1.
2006
When lactate accumulation in a tumor microenvironment reaches an average concentration of 10-20 mM, it tends to reflect a high degree of malignancy. However, the hypothesis that tumor-derived lactate has a number of partially adverse biological effects on malignant and tumor-associated host cells requires further evidence. The present study attempted to evaluate the impact of lactate on the process of angiogenesis, in particular on the formation of tubular structures. The endothelial cell (EC) network in desmoplastic breast tumors is primarily located in areas of reactive fibroblastic stroma. We employed a fibroblast-endothelial cell co-culture model as in vitro angiogenesis system normally…
Review of sustainable solar hydrogen production using photon fuel on artificial leaf
2017
Abstract Energy conversion from the renewable energy sources with suitable energy storage plays a vital role in the sustainable development. Sustainable hydrogen production from the solar energy is well suited for energy storage applications because of inherent high mass energy density of hydrogen. This manuscript reviewing the techniques required for the sustainable solar hydrogen production using photon fuel on artificial leaf, i.e. solar cell. The designing and assembling of artificial solar leaf, which is the replica of natural leaf and capable of harnessing full solar spectrum, are deliberated. This technology for sustainable solar hydrogen production will overlay a viable way for more…
Conservative swept volume boundary approximation
2010
We present a novel technique for approximating the boundary of a swept volume. The generator given by an input triangle mesh is rendered under all rigid transformations of a discrete trajectory. We use a special shader program that creates offset geometry of each triangle on the fly, thus guaranteeing a conservative rasterization and correct depth values. Utilizing rasterization mechanisms and the depth buffer we then get a conservative voxelization of the swept volume (SV) and can extract a triangle mesh from its surface. This mesh is simplified maintaining conservativeness as well as an error bound measured in terms of the one-sided Hausdorff distance. For this we introduce a new techniqu…
A computational approach to evaluate temperature and heat partition in machining with multilayer coated tools
2003
Abstract In this paper, analytical models for estimating the interface temperature and heat partition to the chip in continuous dry machining of steels with flat-faced tools treated with multilayer coatings are presented. The database for modeling includes changes in the thermal properties of both workpiece and substrate/coating materials and the Peclet and Fourier numbers occurring at actual interface temperatures. Process outputs involve the average tool–chip interface temperature, the tool–chip contact length, the friction energy and the heat balance between the moving chip and stationary tool. It was found that the heat partition coefficient varies significantly from 0.65 to 0.8 when us…
A mixed FES/EMG system for real time analysis of muscular fatigue
2010
International audience; In this article, we present a functional electrical stimulator allowing the extraction in real time of M-wave characteristics from resulting EMG recodings in order to quantify muscle fatigue. This system is composed of three parts. A Labview software managing the stimulation output and electromyogram (EMG) input signal, a hardware part amplifying the output and input signal and a link between the two previous parts which is made up from input/output module (NIdaq USB 6251). In order to characterize the fatigue level, the Continuous Wavelet Transform is applied yielding a local maxima detection. The fatigue is represented on a scale from 0 for a fine shaped muscle to …
Fibre-Optic Links For A Measurement And Control System At A HV Laboratory
1990
The paper presents a fibre-optic linking system for a measurement and control system installed at an industrial HV laboratory. The indirect voltage and current measurement system is furnished with the E0/0E transducers and FO links. The exploitation requirements on the adequate measurement accuracy and reliability have necessitated the inclusion of additional, digital PO link feedback from the computer control system. The proposed measurement system with the FO link has been installed at an HV laboratory transformer of an electric power station and successfully tested together with the overall equipment.