Search results for "Transform"
showing 10 items of 3975 documents
Linking transformational leadership to nurses’ extra-role performance: the mediating role of self-efficacy and work engagement
2011
salanova m., lorente l., chambel m.j. & martinez i.m. (2011) Linking transformational leadership to nurses’ extra-role performance: the mediating role of self-efficacy and work engagement. Journal of Advanced Nursing 67(9), 2256–2266. Abstract Aims. This paper is a report of a social cognitive theory-guided study about the link between supervisors’ transformational leadership and staff nurses’ extra-role performance as mediated by nurse self-efficacy and work engagement. Background. Past research has acknowledged the positive influence that transformational leaders have on employee (extra-role) performance. However, less is known about the psychological mechanisms that may explain the lin…
Properties of hyperons in chiral perturbation theory
2009
The development of chiral perturbation theory in hyperon phenomenology has been troubled due to power-counting subtleties and to a possible slow convergence. Furthermore, the presence of baryon-resonances, e.g. the lowest-lying decuplet, complicates the approach, and the inclusion of their effects may become necessary. Recently, we have shown that a fairly good convergence is possible using a renormalization prescription of the loop-divergencies which recovers the power counting, is covariant and consistent with analyticity. Moreover, we have systematically incorporated the decuplet resonances taking care of both power-counting and $consistency$ problems. A model-independent understanding o…
Oxidative stress in environmental-induced carcinogenesis.
2009
Reactive oxygen species (ROS) are the more abundant free radicals in nature and have been related with a number of tissue/organ injuries induced by xenobiotics, ischemia, activation of leucocytes, UV exposition, etc. Oxidative stress is caused by an imbalance between ROS production and a biological system's ability to readily detoxify these reactive intermediates or easily repair the resulting damage. Thus, oxidative stress is accepted as a critical pathophysiological mechanism in different frequent human pathologies, including cancer. In fact ROS can cause protein, lipid, and DNA damage, and malignant tumors often show increased levels of DNA base oxidation and mutations. Different lifesty…
Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydro…
2008
Human diploid fibroblasts (HDFs) exposed to subcytotoxic stresses under H2O2, tert-butylhydroperoxide (t-BHP), and ethanol (EtOH) undergo stress-induced premature senescence (SIPS) characterized by many biomarkers of HDFs replicative senescence. Among these biomarkers are a growth arrest, an increase in the senescence-associated β-galactosidase activity, a senescent morphology, an overexpression of p21waf-1 and the subsequent inability to phosphorylate pRb, the presence of the common 4977-bp mitochondrial deletion, and an increase in the steady-state level of several senescence-associated genes such as apolipoprotein J (apo J). Apo J has been described as a survival gene against cytotoxic s…
Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B.
1996
Both the aging of animals and the senescence of cultured cells involve an altered pattern of gene expression, suggesting changes in transcription factor regulation. We studied age-related changes in transcription factors nuclear factor (NF)-kappa B, activator protein factor-1 (AP-1) and Sp-1 by using electrophoretic mobility shift binding assays; we also analysed changes in the protein components of NF-kappa B complex with Western blot assays. Nuclear and cytoplasmic extracts were prepared from heart, liver, kidney and brain of young adult and old NMRI mice and Wistar rats as well as from presenescent, senescent and simian virus 40-immortalized human WI-38 fibroblasts. Aging of both mice an…
Attenuation of NF-κB Signaling Response to UVB Light during Cellular Senescence
1999
The ability of cells to adapt to environmental stresses undergoes a progressive reduction during aging. NF-kappaB-mediated signaling is a major defensive system against various environmental challenges. The aim of this study was to find out whether replicative senescence affects the response of the NF-kappaB signaling pathway to UVB light in human WI-38 and IMR-90 fibroblasts. The exposure of early passage fibroblasts to UVB light inhibited the proliferation and induced a flat phenotype similar to that observed in replicatively senescent fibroblasts not exposed to UVB light. The UVB radiation dose used (153 mJ/cm2) did not induce apoptosis in either early or late passage WI-38 fibroblasts. …
Is chlamydial heat shock protein 60 a risk factor for oncogenesis?
2004
Heat shock protein 60 (HSP60) plays an important role in the protein folding of prokaryotic and eukaryotic cells. Most of the papers published on chlamydial HSP60 concern its role in immune response during infection. In the last decade, exposure to Chlamydia trachomatis has been consistently associated with the development of cervical and ovarian cancer. Moreover, it has been suggested that chlamydial HSP60 may have an anti- apoptotic effect during persistent infection. We hypothesize that the accumulation of exogenous chlamydial HSP60 in the cytoplasm of actively replicating eukaryotic cells may interfere with the regulation of the apoptotic pathway. The concomitant expression of viral onc…
Silhouette encoding and synthesis using elliptic Fourier descriptors, and applications to videoconferencing
2004
Abstract This paper investigates the use of elliptic Fourier descriptors as a shape descriptor for encoding the silhouette of a person. Shape descriptors are here used for predicting the shape of silhouettes in missing frames within a sequence. This prediction scheme is applied to the case of generating in-between images in a low frame rate videoconferencing system, where the reconstructed silhouette is used as a binary mask for reducing the computational time for the frame reconstruction.
Recent developments in flow-analysis vibrational spectroscopy
2007
Abstract This review deals with developments in the new century on the use of vibrational spectroscopy techniques for detection in flow-injection analysis (FIA) systems. To provide a picture of the evolution, highlights and future developments in this field, we revisited Fourier transform infrared (FTIR), in the mid-IR and near-IR ranges, and FT-Raman spectrometry applications using different approaches, from classical FIA to modern (sequential injection analysis (SIA) or multicommutation). We used the analytical abstracts database for 2000–06 for the literature search, but we based this review very much on the experience of our team in this field.
Employee-driven digitalization in healthcare: codesigning services that deliver
2020
Abstract The purpose of this article is to explore and conceptualize how Nordic principles of employee participation combined with enterprise social media/web 2.0 could enable co-creation as an input to digital transformation of healthcare services. The question of how to enable effective co-creation is both under-researched and stated as an important enabler of digitalization and service improvements. The article starts by introducing The Nordic Model for employee participation that is proven successful for enhancing working life effectiveness and innovation. We then discuss how these principles of participation can be further enhanced by state-of-the-art web 2.0 technologies for Enterpris…