Search results for "Translation"
showing 10 items of 1324 documents
A multifunctional bicupin serves as precursor for a chromosomal protein of Pisum sativum seeds.
2005
The fact that the psp54 gene codes for p16, a seed chromatin protein of Pisum sativum, has been described previously. In the present paper it is shown that p54, the p16 precursor, also exists as a free polypeptide in pea and that it also yields p38, a second polypeptide from the N-terminal region of p54, which is co-localized at a subcellular level with p16. By using antibodies against pea p16 and p38, it was found that these proteins are present in the members of the tribe Viciae examined. Sequence analysis and 3D modelling indicates that p54 proteins belong to the cupin superfamily, and that they are related to sucrose binding proteins and, to a lesser extent, to vicilin-type seed storage…
News from an Ancient World: Two Novel Astacin Metalloproteases from the Horseshoe Crab
2008
In this work, we report the cloning, heterologous expression, and characterization of two novel astacin proteases from the chelicerate Limulus polyphemus (horseshoe crab), designated as LAST (Limulus astacin) and LAST_MAM (Limulus astacin containing a MAM domain), respectively. The expression pattern showed ubiquitous occurrence of LAST_MAM, while LAST was predominantly restricted to the eyes and brain, indicating a function in the nervous system. Both enzymes contain the characteristic metzincin-type zinc-binding region and Met turn. While LAST is made up only of the typical prodomain and astacin-like protease domain, LAST_MAM contains an additional MAM (meprin A5 protein tyrosine phosphat…
The 5' Untranslated Region of the
2018
Many of the virulence traits that make Candida albicans an important human fungal pathogen are regulated on a transcriptional level. Here, we report an important regulatory contribution of translation, which is exerted by the extensive 5′ untranslated regulatory sequence (5′ UTR) of the transcript for the protein Efg1, which determines growth, metabolism, and filamentation in the fungus. The presence of the 5′ UTR is required for efficient translation of Efg1, to promote filamentation. Because transcripts for many relevant regulators contain extensive 5′ UTR sequences, it appears that the virulence of C. albicans depends on the combination of transcriptional and translational regulatory mec…
The Many Faces of a Translation
2000
First-order translations have recently been characterized as the maps computed by aperiodic single-valued nondeterministic finite transducers (NFTs). It is shown here that this characterization lifts to "V-translations" and "V-single-valued-NFTs", where V is an arbitrary monoid pseudovariety. More strikingly, 2-way V-machines are introduced, and the following three models are shown exactly equivalent to Eilenberg's classical notion of a bimachine when V is a group variety or when V is the variety of aperiodic monoids: V-translations, V-single-valued-NFTs and 2-way V-transducers.
An integrated architecture for speech-input multi-target machine translation
2007
The aim of this work is to show the ability of finite-state transducers to simultaneously translate speech into multiple languages. Our proposal deals with an extension of stochastic finite-state transducers that can produce more than one output at the same time. These kind of devices offer great versatility for the integration with other finite-state devices such as acoustic models in order to produce a speech translation system. This proposal has been evaluated in a practical situation, and its results have been compared with those obtained using a standard mono-target speech transducer.
Speech-input multi-target machine translation
2007
In order to simultaneously translate speech into multiple languages an extension of stochastic finite-state transducers is proposed. In this approach the speech translation model consists of a single network where acoustic models (in the input) and the multilingual model (in the output) are embedded. The multi-target model has been evaluated in a practical situation, and the results have been compared with those obtained using several mono-target models. Experimental results show that the multi-target one requires less amount of memory. In addition, a single decoding is enough to get the speech translated into multiple languages.
Multiplicative Loops of Quasifields Having Complex Numbers as Kernel
2017
We determine the multiplicative loops of locally compact connected 4-dimensional quasifields Q having the field of complex numbers as their kernel. In particular, we turn our attention to multiplicative loops which have either a normal subloop of dimension one or which contain a subgroup isomorphic to $$Spin_3({\mathbb {R}})$$ . Although the 4-dimensional semifields Q are known, their multiplicative loops have interesting Lie groups generated by left or right translations. We determine explicitly the quasifields Q which coordinatize locally compact translation planes of dimension 8 admitting an at least 16-dimensional Lie group as automorphism group.
Quo vadis, CIUTI?
2012
Le présent article retrace le cheminement de la CIUTI depuis 50 ans, c’est-à-dire son développement en une organisation réputée ayant à son actif 40 membres en Europe et dans le monde. À ses débuts, la CIUTI avait certes comme but essentiel la promotion de la coopération entre ses membres (mobilité des étudiants et des enseignants, échange de connaissances), mais son autre objectif était de promouvoir la traductologie dans les universités en tant que discipline à part entière. L’auteur affirme qu’être membre de la CIUTI a une valeur symbolique qui confère, de ce fait, un capital social valorisant, sur les plans national et international, notamment en ce qui concerne le classement des instit…
Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition
2020
Abstract The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a potential opportunity for treatment of NPM1-mutant (NPM1mut) and MLL-rearranged (MLL-r) leukemias. Concomitant activating driver mutations in the gene encoding the tyrosine kinase FLT3 occur in both leukemias and are particularly common in the NPM1mut subtype. In this study, transcriptional profiling after pharmacological inhibition of the menin-MLL complex revealed specific changes in gene expression, with downregulation of the MEIS1 transcription factor and its transcriptional target gene FLT3 being the most pronounced. Combining menin-MLL inhibition with specific small-molecule kinase inhibitors…
A narratological approach to content selection in audio description: towards a strategy for the description of narratological time
2012
As more and more countries start to provide audio description services for a growing range of products and events, research into this new discipline is growing and diversifying as well. Two questions that seem to be at the heart of much of this research focus on what should be described and how this should be done, in other words on content selection and formulation of the description. The present article looks at the first of these two questions and approaches it from a narratological point of view. After a general discussion of the use of narratology for audio description, the focus will shift to one particular constituent of narrative, namely time. The different temporal aspects will be …