Search results for "Trichophyton"
showing 5 items of 5 documents
Effect of a Killer Toxin of Yeast on Eucaryotic Systems
1988
The Saccharomyces cerevisiae killer toxin KT 28, which inhibits sensitive yeasts, was shown to have no effect on several pathogenic fungi or on the protozoan Trichomonas vaginalis. At concentrations of about 0.1 mg/ml, a partial inhibition of the skin pathogenic fungi Trichophyton rubrum and Microsporum canis was observed at pH 6.5. No pharmacological activity was detected in various tests with several animal organs.
Transformation of the dermatophyte Trichophyton mentagrophytes to hygromycin B resistance.
1989
A transformation system for the ringworm-producing dermatophyte Trichophyton mentagrophytes has been developed. The system employs the plasmid pHIS, which contains a bacterial hygromycin B phosphotransferase gene linked to Cochliobolus heterostrophus regulatory sequences (B. G. Turgeon, R. C. Garber, and O. C. Yoder, Mol. Cell. Biol. 7:3297-3305, 1987). This plasmid confers hygromycin B resistance to T. mentagrophytes. The DNA was stably integrated into the fungal genome, and the number and sites of integrations varied among transformants. Transformant clones were capable of infecting guinea pigs. This system opens the way for the molecular genetic analysis of the interaction of T. mentagro…
Antimykotische Wirkstoffe, Mitt. Chlor-(1-piperazinyl)-1,3,5-triazine
1988
Aus der Umsetzung von Cyanurchlorid (1) mit den Piperazinderivaten 2a–c bei –20 bis 10° gehen die Dichlor-(1-piperazinyl)-1,3,5-triazine 3a–c hervor. Bei der erhohten Reaktionstemperatur von 40° erfolgt aus 1 und den Piperazinderivaten 4a–b Bildung der 2-Chlor-4,6-bis(piperazinyl)-1,3,5-triazine 5a–b. Zu gemischt substituierten Chlor-1,3,5-triazinen 9 fuhrt die nacheinander erfolgende Umsetzung von 1 mit 2 verschiedenen cyclischen sekundaren Aminen (6 und 8). Die Strukturtypen 3, 5 und 9 zeigen in den 1H-NMR-Spektren zwei fur Piperazinringe charakteristische Signalgruppen im Bereich 2.4–4.0 ppm. Unter den neu entwickelten Verbindungen finden sich Vertreter mit sehr starker antimykotischer W…
Contribution to the Knowledge of Dermatophytic Invasion of Hair
1970
We have used the scanning electron microscope to investigate the changes that occur in scalp hair during infection with Trichophyton violaceum . We provide information on the morphology of these dermatophytes and present evidence that their hyphae dig tunnel-like burrows into the hair shaft, dissociating hair into keratin fibrils.
Immunology of dermatophytosis
1983
By causing experimental lesions of dermatophytosis in rabbits inoculated and reinoculated with T. mentagrophytes var. granulosum and T. rubrum a study was carried out of the state of cellular immunity response, during infection, and also of the antigens responsible for the sensitization. Cellular immunity response was detected using the leucocyte migration test (L.M.T.) in the presence of antigenic compounds of the 'Keratinase' of Eleuterio et al.