Search results for "Twin"

Is diversity of leisure-time sport activities associated with low back and neck–shoulder region pain? A Finnish twin cohort study

2019

This study investigates cross-sectional and longitudinal associations between the diversity of leisure-time sport activities and the frequencies of low back pain (LBP) and neck-shoulder region pain (NSP) in twins, including a cross-sectional within-pair design to adjust for potential familial confounding. Finnish twins born in 1975–79 (FinnTwin16 study) reported participation in leisure-time sport activities at the mean ages of 17 (1992–96) (n = 5096, 54% females) and 34 years (2010−12) (n = 3731, 57% females). Diversity assessed as the number of sport activities was categorized as 1, 2, 3, 4, and ≥ 5, excluding inactive individuals. The frequencies of LBP (n = 3201) and NSP (n = 3207), rep…

The Association Between Epigenetic Clocks and Physical Functioning in Older Women: A 3-Year Follow-up

2021

Abstract Background Epigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between 4 epigenetic clocks (Horvath’s and Hannum’s DNAmAge and DNAm GrimAge and PhenoAge) and physical functioning during a 3-year follow-up. Method We studied 63- to 76-year-old women (N = 413) from the Finnish Twin Study on Aging. DNAm was measured from blood samples at baseline. Age acceleration (AgeAccel), that is, discrepancy between chronological age and DNAm age, was determined as residuals from linear model. Physical functioning was assessed under standardized laboratory conditions at b…

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

2021

AbstractThe aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physical function and body composition. Two independent cohorts (N = 139 and N = 47) were included, whose age span covered adulthood (23–69 years). Whole blood and m. vastus lateralis samples were collected, and DNA methylation was analysed. Four different DNA methylation age (DNAmAge) estimates were calculated using genome-wide methylation data and publicly available online tools. A novel muscle-specific methylation age was estimated using the R-package ‘MEAT’. PA was measured with q…

Health & safety 4.0: A digital twin reference model to support the smart operator at the workplace

2020

In the Industry 4.0 era, Cyber-Physical Systems (CPS) and the Internet of Things are the enabling technologies for a new tool, the Digital Twin, that allows a streamlined communication, automation and interoperability among all the production assets. Even if there has been a great deal of efforts toward digital twin engineering, little attention has been paid to the correct integration of humans in the emerging context of smart factories and, in particular, to the potential contribution of digital twins for supporting a health and safety 4.0 at the workplace. This paper sets the stage for a discussion over health and safety aspects for the Smart Operator and proposes a renewed approach to t…

A Critical Review of Statistical Methods for Twin Studies Relating Exposure to Early Life Health Conditions

2021

International audience; When investigating disease etiology, twin data provide a unique opportunity to control for confounding and disentangling the role of the human genome and exposome. However, using appropriate statistical methods is fundamental for exploiting such potential. We aimed to critically review the statistical approaches used in twin studies relating exposure to early life health conditions. We searched PubMed, Scopus, Web of Science, and Embase (2011–2021). We identified 32 studies and nine classes of methods. Five were conditional approaches (within-pair analyses): additive-common-erratic (ACE) models (11 studies), generalized linear mixed models (GLMMs, five studies), gene…

On the family of $r$-regular graphs with Grundy number $r+1$

2014

International audience; The Grundy number of a graph $G$, denoted by $\Gamma(G)$, is the largest $k$ such that there exists a partition of $V(G)$, into $k$ independent sets $V_1,\ldots, V_k$ and every vertex of $V_i$ is adjacent to at least one vertex in $V_j$, for every $j < i$. The objects which are studied in this article are families of $r$-regular graphs such that $\Gamma(G) = r + 1$. Using the notion of independent module, a characterization of this family is given for $r=3$. Moreover, we determine classes of graphs in this family, in particular the class of $r$-regular graphs without induced $C_4$, for $r \le 4$. Furthermore, our propositions imply results on partial Grundy number.

P03.04: The influence of mode of conception, fetal gender and twin pregnancy in the development of cerebral structures: a fetal brain 3D ultrasound s…

2006

Influence of Twinning Microstructure of Crystals with Low Tetragonality on a X-Ray Diffraction

2001

The intensity distributions of the X-rays scattered in the tetragonal single crystal, which represent a complex of the twin domains separated by the coherent parallel boundaries, are simulated. The calculations are performed by using the Monte Carlo method within the framework of a kinematical approach. The thickness distributions of the twin domains are defined according to the geometrical, Gaussian and log normal functions. ‘Critical’ effects of the X-ray scattering are found, namely there is transformation of the tetragonal doublet into singlet or multiplet. As demonstrated, each of characteristics of the tetragonal doublet profile depends on a few parameters of the twin microstructure o…

Agreement on the Choice of Non-applicable Law or Law not in Accordance with Article 22(1) of the Twin Regulations: what Consequences for the Couple’s…

2021

Los Reglamentos (UE) 2016/1103 y 2016/1104 del Consejo autorizan a las parejas transfronterizas a elegir la ley aplicable a sus relaciones patrimoniales sobre la base de uno de los criterios enumerados en el artículo 22.1. Sin embargo, el acuerdo de elección de la ley puede tener un contenido diferente al señalado en la redacción del artículo 22 de los ?Reglamentos Gemelos?. El objetivo del análisis es ilustrar que sería incorrecto sostener que tales acuerdos son, a priori, inválidos o no permiten la autonomía de la voluntad. Esta cuestión requiere una evaluación de la finalidad concreta del acuerdo de las partes y debería, al menos, estar abierta al examen del tribunal competente.

Evidence for shared environmental contributions to attention-deficit/hyperactivity traits. A twin study

2019

Background and objectives: Behavior-genetic analyses have shown that measurements of inattention and hyperactivity-impulsivity are genetically-influenced. In view of limited studies on ADHD (Attention deficit hyperactivity disorder) in Spanish samples, this study aims to explore the genetic architecture of ADHD symptoms; inattention and hyperactivity-impulsivity in a Spanish twin schoolchildren sample. Methods: Participants were 258 pairs of adolescent Spanish twins. Symptoms of ADHD, inattention and hyperactivity-impulsivity were assessed by means of a sub-scale of the Strengths and Difficulties Questionnaire. Univariate twin models, according to sex, were run to assess the heritability of…