Search results for "Type"

Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations

1999

Two biallelic polymorphisms in introns 3 and 6 of the p53 gene were analysed for a possible risk-modifying effect for ovarian cancer. Germline DNA was genotyped from 310 German Caucasian ovarian cancer patients and 364 healthy controls. We also typed 124 affected and 276 unaffected female carriers with known deleterious BRCA1 or BRCA2 germline mutation from high-risk breast-ovarian cancer families. Genotyping was based on PCR and high-resolution gel electrophoresis. German ovarian cancer patients who carried the rare allele of the MspI restriction fragment length polymorphism (RELP) in intron 6 were found to have an overall 1.93-fold increased risk (95% confidence internal (CI) 1.27–2.91) w…

p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53

2010

10 p.-5 fig.

The action of a compact Lie group on nilpotent Lie algebras of type {{n,2}}

2015

Abstract We classify finite-dimensional real nilpotent Lie algebras with 2-dimensional central commutator ideals admitting a Lie group of automorphisms isomorphic to SO 2 ⁢ ( ℝ ) ${{\mathrm{SO}}_{2}(\mathbb{R})}$ . This is the first step to extend the class of nilpotent Lie algebras 𝔥 ${{\mathfrak{h}}}$ of type { n , 2 } ${\{n,2\}}$ to solvable Lie algebras in which 𝔥 ${{\mathfrak{h}}}$ has codimension one.

Yhdyskuntajätevedenpuhdistamon rejektivesien erilliskäsittely : biologinen typenpoisto panostoimisessa reaktorissa ja ftalaattien käyttäytyminen pros…

2006

Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella

2017

The α-proteobacterial genus Bartonella comprises a group of ubiquitous mammalian pathogens that are studied as a model for the evolution of bacterial pathogenesis. Vast abundance of two particular phylogenetic lineages of Bartonella had been linked to enhanced host adaptability enabled by lineage-specific acquisition of a VirB/D4 type IV secretion system (T4SS) and parallel evolution of complex effector repertoires. However, the limited availability of genome sequences from one of those lineages as well as other, remote branches of Bartonella has so far hampered comprehensive understanding of how the VirB/D4 T4SS and its effectors called Beps have shaped Bartonella evolution. Here, we repor…

On the relations between parents’ and children’s implicit and explicit academic gender stereotypes.

2017

Although parents may represent influential sources of children’s gender stereotypes, to date no study has directly investigated the relations between parents’ and children’s gender stereotypes regarding academic abilities. Aiming at filling this gap, in the present study parents’ and their young children’s gender stereotypes about math and language were assessed using both explicit and implicit measures for each member of the family. Sixty-eight Italian 6-year-olds, their mothers, and their fathers (a) performed an Implicit Association Test designed to assess implicit gender stereotypes about math and language, and (b) completed a measure of the relevant explicit stereotypes. Fathers’, but …

Motor Transitions' Peculiarity of Heterozygous DAT Rats When Offspring of an Unconventional KOxWT Mating.

2020

Abstract Causal factors of psychiatric diseases are unclear, due to gene × environment interactions. Evaluation of consequences, after a dopamine-transporter (DAT) gene knock-out (DAT-KO), has enhanced our understanding into the pathological dynamics of several brain disorders, such as Attention-Deficit/Hyperactivity and Bipolar-Affective disorders. Recently, our attention has shifted to DAT hypo-functional (heterozygous, HET) rodents: HET dams display less maternal care and HET females display marked hypo-locomotion if cared by HET dams (Mariano et al., 2019). We assessed phenotypes of male DAT-heterozygous rats as a function of their parents: we compared “maternal” origin (MAT-HET, obtain…

Parliamentarisation as Politicisation

2021

Understanding politics as a contingent and controversial activity, politicisation refers to those activities that create or make visible the political quality in the phenomena in question. Parliamentarisation is a distinct strategy of politicisation. In this chapter, parliament refers to a certain procedural and institutional ideal type of acting politically. The parliamentary way of politicising acting and thinking forms a Gedankenbild, a mental image. It is an ideal type that one-sidedly accentuates and intensifies the political way of thinking. The parliamentary way of proceeding politically transcends the given polity: ‘parliament’ is not primarily a parliament ‘of’ a unit, such as the …

Open-source QCD analysis of nuclear parton distribution functions at NLO and NNLO

2019

We present new sets of nuclear parton distribution functions (nPDFs) at next-to-leading order (NLO) and next-to-next-to-leading order (NNLO). Our analyses are based on deeply inelastic scattering data with charged-lepton and neutrino beams on nuclear targets. In addition, a set of proton baseline PDFs is fitted within the same framework with the same theoretical assumptions. The results of this global QCD analysis are compared to existing nPDF sets and to the fitted cross sections. Also, the uncertainties resulting from the limited constraining power of the included experimental data are presented. The published work is based on an open-source tool, xFitter, which has been modified to be ap…

Reconceptualising the Role of Talk in CLIL

2011

This theoretical paper offers a reconceptualisation of talk in CLIL based on sociocultural and dialogic theories of education. Building on these educational theories and the experiences of an on-going CLIL project, this paper presents a pedagogical model for the navigation of the ‘talkscape’ of the CLIL classroom. This model comprises a total of seven talk-types: organisational, social, critical, expert, exploratory, meta and pedagogic. In addition to these talk-types, the paper introduces the notion of a ‘transitional dynamic’. This notion aims to capture the transition from first language to foreign language use in CLIL both within the context of individual courses and across a broader CL…