Search results for "ULB"

Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis

2009

Proliferation in the subependymal zone (SEZ) and neurogenesis in the olfactory bulb decline in the forebrain of telomerase-deficient mice. The present work reveals additional effects of telomere shortening on neuronal differentiation, as adult multipotent progenitors with critically short telomeres yield reduced numbers of neurons that, furthermore, exhibit underdeveloped neuritic arbors. Genetic data indicate that the tumor suppressor protein p53 not only mediates the adverse effects of telomere attrition on proliferation and self-renewal but it is also involved in preventing normal neuronal differentiation of adult progenitors with dysfunctional telomeres. Interestingly, progenitor cells …

Choline is a Selective Agonist of α7 Nicotinic Acetylcholine Receptors in the Rat Brain Neurons

1998

In the present study, we demonstrate that choline, a precursor of acetylcholine (ACh) and a product of acetylcholine hydrolysis by acetylcholinesterase (AChE), acts as an efficient and relatively selective agonist of alpha7-containing nicotinic acetylcholine receptors (nAChR) in neurons cultured from the rat hippocampus, olfactory bulb and thalamus as well as in PC12 cells. Choline was able to activate postsynaptic and presynaptic alpha7 nAChRs, with the latter action resulting in the release of other neurotransmitters. Although choline was approximately one order of magnitude less potent than ACh (EC50 of 1.6 mM for choline and 0.13 mM for ACh), it acted as a full agonist at alpha7 nAChRs.…

Effetti della concimazione sulla qualità dell'aglio coltivato in Sicilia

2009

Effetti della concimazione sulla qualità dell'aglio coltivato in Sicilia. Effects of fertilization on the quality of garlic grown in Sicily.

2010

In order to expand this crop and to improve bulbs quality a study was carried out to evaluate different fertilization techniques. Four fertilization formulas were evaluated: 1) mineral fertilization commonly used by Paceco producers - pre-planting with 55, 110 and 80 kg ha-1 of N, P2O5 and K2O - post planting with 47 and 46 kg ha-1 of N and K2O; 2) organic fertilization with an organic mix - pre-planting with 320 and 240 kg ha-1 of N and P2O5; 3) mineral fertilization - pre-planting with 40, 70 and 100 kg ha-1 of N, P2O5 and K2O - post-planting with 80 kg ha-1 of N half at 3-4 leaves and half at bulbs formation; 4) only post-planting fertilization with 52 and 184 kg ha-1 of N and K2O, half …

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

2021

LRP1-targeted St-Cl–polyglutamate conjugates as multivalent neuroprotective/neurotrophic therapeutics for Alzheimer’s disease.

Mean Radiant Temperature Measurements through Small Black Globes under Forced Convection Conditions

2021

One of the most critical variables in the field of thermal comfort measurements is the mean radiant temperature which is typically measured with a standard 150 mm black globe thermometer. This is also the reference instrument required for the assessment of heat stress conditions by means of the well-known Wet Bulb Globe Temperature index (WBGT). However, one of the limitations of this method is represented by the relatively long response time. This is why in recent years there has been a more and more pressing need of smart sensors for controlling Heating Ventilation and Air Conditioning (HVAC) systems, and for pocket heat stress meters (e.g., WBGT meters provided with table tennis balls). …

Enterococcal meningitis caused by Enterococcus casseliflavus. First case report

2005

Abstract Background Enterococcal meningitis is an uncommon disease usually caused by Enterococcus faecalis and Enterococcus faecium and is associated with a high mortality rate. Enterococcus casseliflavus has been implicated in a wide variety of infections in humans, but never in meningitis. Case presentation A 77-year-old Italian female presented for evaluation of fever, stupor, diarrhea and vomiting of 3 days duration. There was no history of head injury nor of previous surgical procedures. She had been suffering from rheumatoid arthritis for 30 years, for which she was being treated with steroids and methotrexate. On admission, she was febrile, alert but not oriented to time and place. H…

Zvaigžņotā Debess: 2010/11, Ziema (210)

2010

Contents: “ZVAIGŅOTĀ DEBESS” FORTY YEARS AGO: Bursting Stars. J. Francman (abridged). Geodesists Help Renew the Spire of St. Peter’s Church. J. Klētnieks (abridged). DEVELOPMENTS in SCIENCE: The Solar Neutrino Problem. O. Smirnova. NEWS: At Last the Planet at the Star β Pictoris Is Imaged. A. Alksnis, Z. Alksne. SPACE RESEARCH and EXPLORATION: The Trail of an Asteroid Reveals a Recent Collision. A. Alksnis. INTERNATIONAL YEAR of ASTRONOMY 2009: International Year of Astronomy 2009 in Philately. The Rest of the World except Series EUROPA (concluded). J. Limansky. ACADEMIC STAFF of the UNIVERSITY of LATVIA: Assistant Professor in Physics Ojārs Šmits (24.04.1930.-14.03.1993.) of the Latvian Un…

Soluble guanylyl cyclase appears in a specific subset of periglomerular cells in the olfactory bulb

2005

In the brain, nitric oxide acts as an atypical messenger in cellular nonsynaptic transmission. In the olfactory bulb, this gas is produced at the level of the olfactory glomeruli by a subpopulation of periglomerular cells that participates in the first synaptic relay of the olfactory information between the olfactory nerve and the dendritic tufts of principal cells. It has been proposed that nitric oxide modulates intraglomerular synaptic integration of sensory inputs, but its specific role in the glomerular circuitry remains to be understood. In this article, we demonstrate that, in the glomerular circuits, a specific subset of periglomerular cells, most of them expressing the calcium bind…

VIP-containing deep short-axon cells of the olfactory bulb innervate interneurons different from granule cells

2003

This study investigates the targets of the population of vasoactive intestinal polypeptide (VIP)-containing deep short-axon cells of the rat olfactory bulb (OB), combining single- and double-immunocytochemical approaches under light and electron microscopy. It has been assumed that deep short-axon cells innervate granule cells in the mammalian OB, but their synaptic connectivity has not been demonstrated to date. Our results indicate that, instead of the accepted scheme of the bulbar circuitry, VIP-containing deep short-axon cells are gamma-aminobutyric acid (GABA)ergic interneurons specialized in the selective innervation of other GABAergic deep short-axon cells. Their axons contact with t…