Search results for "Ulcer"
showing 10 items of 523 documents
Patología articular en la enfermedad inflamatoria intestinal
2005
The joint disorders taxonomically included in the group of seronegative spondyloarthropathies under the generic name of enteropathic arthropathy represent the most frequent extra-intestinal manifestation of inflammatory bowel disease (IBD), affecting 33% of patients. Their frequency is similar to that of ulcerative colitis and Crohn's disease. Enteropathic arthropathy consists of two main joint alterations, peripheral and axial arthritis, as well as a variable group of other peri-articular disorders. Type 1, or pauciarticular, peripheral arthritis generally coincides with IBD exacerbations, while type 2, or polyarticular, peripheral arthritis follows an independent course from IBD. Axial in…
Non-healing tongue ulcer in a rheumatoid arthritis patient medicated with leflunomide. An adverse drug event?
2017
Leflunomide is a member of the disease modifying anti-rheumatic drugs group used as a treatment modality in active rheumatoid and psoriatic arthritis. “Oral ulcers” are reported in 3-5% of leflunomide medicated rheumatoid arthritis patients with adverse events, but they are not described in detail in the literature. We present a case of an ulcer in the tongue of a rheumatoid arthritis patient managed with leflunomide and contemplate on its pathogenesis. Key words:Leflunomide, oral ulcer, DHODH.
Arthritis Associated with Ulcerative Colitis: Our Experience in Palermo
2009
To The Editor: Ulcerative colitis (UC) is one of the inflammatory bowel diseases, which affects the small intestine and colon [1]. The pathophysiology of UC is not known [2, 3]. The association between arthritis and UC is well known. The authors report the frequency of arthritis in 53 Sicilian patients with UC. The diagnosis of UC was made according to criteria described by Schachter and Kirsner [4]. The involvement of sacroilitic joints was assessed radiologically according to Bennett and Burch grade (0=normal joint, 1=suspicious sacroiliitis 2=abnormal joint with sclerosis and/or erosions, 3=unequivocally abnormal with erosions, sclerosis, widening or narrowing or partly ankylosed, 4=tota…
Emergence of severe spondyloarthropathy-related entheseal pathology following successful vedolizumab therapy for inflammatory bowel disease
2018
Objectives Vedolizumab (VDZ) blocks α4β7 integrin and is licenced for the treatment of IBD. It has been associated with mild SpA-related features, including sacroiliitis and synovitis. Herein we report a series of cases demonstrating the emergence of severe SpA-associated enthesitis/osteitis following successful IBD therapy with VDZ. Methods We evaluated 11 VDZ-treated patients with IBD across seven centres who developed severe active SpA and/or enthesopathy, with the aim of characterizing the VDZ-associated SpA or entheseal flares. Imaging features demonstrating particularly severe disease were recorded. Results De novo SpA developed in 9 of 11 patients and flare of known SpA in 2 patients…
Wielokierunkowe i całościowe podejście do leczenia żylnych owrzodzeń goleni
2011
Niniejszy artykuł omawia aspekty leczenia owrzodzeń żylnych goleni. Ze względu na niezwykle złożoną patologię ran przewlekłych, do których jest zaliczane żylne owrzodzenie goleni, tylko wielokierunkowe i całościowe podejście do leczenia może dać pożądany efekt kliniczny. Skuteczny system leczenia owrzodzeń powinien obejmować: opiekę pielęgniarską w miejscu zamieszkania chorego, specjalistyczne leczenie w centrum leczenia ran oraz rozwiązywanie psychospołecznych problemów osoby chorej w klubie pacjentów. Leczenie owrzodzeń żylnych powinno być poprzedzone diagnostyką owrzodzenia, mającą na celu wykluczenie innych przyczyn owrzodzenia niż żylne oraz wykrycie patologii, którą można skorygować c…
Algorytmy i wytyczne postępowania terapeutycznego w ranach trudno gojących się
2020
Niniejsze opracowanie obejmuje podstawowy zbiór zasad i rekomendacji specjalistów z różnych dziedzin medycyny dotyczących postępowania z ranami o różnych etiologiach. Celem dokumentu jest stworzenie algorytmów terapeutycznych, które będą mogły stanowić podstawę przy ocenie rany, monitoringu i doborze optymalnej metody postępowania w poszczególnych etapach jej leczenia. Dokument w swoich założeniach ma stanowić przydatne narzędzie dla praktyków, które ułatwi prawidłowe podejmowanie decyzji terapeutycznych w procesie leczenia rany
Oral aphthous-like ulceration due to tiotropium bromide
2007
Unwanted side-effects of a drug therapy are well known to oral medicine specialists and other colleagues. Usually they manifest itself as dry mouth, taste disturbances, various allergic or toxic reactions on the lips and/or in the oral cavity. However, the list of the drugs which might induce unwanted reactions is everyday becoming longer as more and more drugs are introduced on the market. Certain problems when diagnosing and reporting unwanted side effects of the drugs exist as only accurate method of diagnosis is repeated drug use in controlled clinical setting where fatal consequences due to the anaphilactic shock could be avoided. We report a side effect reaction to tiotropium bromide …
Long-Standing oral ulcers: proposal for a new S-C-D classification system'
2009
Persistent oral ulcers and erosions can be the final common manifestation, sometimes clinically indistinguishable, of a diverse spectrum of conditions ranging from traumatic lesions, infectious diseases, systemic and local immune-mediated lesions up to neoplasms. The process of making correct diagnosis for persistent oral ulcers still represents a challenge to clinicians. Major diagnostic criteria should include the clinical appearance of both ulcer and surrounding non-ulcerated mucosa, together with the evaluation of associated signs and symptoms, such as: number (single or multiple), shape, severity of the ulcer(s), conditions of remaining mucosa (white, red or with vesiculo-bullous lesio…