Search results for "Unity"

Management of Childhood Obesity—Time to Shift from Generalized to Personalized Intervention Strategies

2021

As a major public health concern, childhood obesity is a multifaceted and multilevel metabolic disorder influenced by genetic and behavioral aspects. While genetic risk factors contribute to and interact with the onset and development of excess body weight, available evidence indicates that several modifiable obesogenic behaviors play a crucial role in the etiology of childhood obesity. Although a variety of systematic reviews and meta-analyses have reported the effectiveness of several interventions in community-based, school-based, and home-based programs regarding childhood obesity, the prevalence of children with excess body weight remains high. Additionally, researchers and pediatric c…

Predictors for Nursing Home Admission and Death among Community-Dwelling People 70 Years and Older Who Receive Domiciliary Care

2015

Original Research Article Aim: The aim of this study was to analyze which variables predicted nursing home admission (NHA) and death. Methods: 1,001 recipients of domiciliary care were assessed three times in a 3-year period. Through bivariate and multivariate Cox proportional hazards regression models, associations between a covariate and the outcomes were analyzed. Results: Participants with dementia had a higher risk of NHA (odds ratio 3.88, 95% confidence interval 2.92-5.16) compared to participants without dementia. The Neuropsychiatric Inventory sub-syndrome psychosis, poorer functional impairment and age were associated with NHA. Female sex, age, worse medical health and functional i…

Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysi…

2022

ABSTRACTIntroductionBehavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of intervention-covariate interactions. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commen…

Tools to identify nutritional risk for older people in the home

2012

Author's version of an article in the journal: British Journal of Community Nursing. Community nurses are in an ideal position to identify older home-dwelling people at nutritional risk and thereby to prevent undernutrition. The aim of this paper is to present some nutritional screening instruments for older home-dwelling people and to discuss nutritional issues of importance for community nurses in order to assess nutritional risk and prevent undernutrition. The screening instruments Nutritional Form For the Elderly (NUFFE) and Mini Nutritional Assessment (MNA) are especially developed for screening older people. The Malnutrition Universal Screening Tool (MUST) is recommended for screening…

C’è un altro cielo. Parchi e Giardini a New York

2017

I giardini a New York, e soprattutto a Manhattan, tra le città più compatte del pianeta, mostrano come gli spazi aperti abbiano una specifica densità, rispetto al costruito e siano un “fronte di resistenza” rispetto ai processi di trasformazione immobiliare, ai Piani, agli interventi pubblici e a quelli privati, cui a volte si oppongono efficacemente le azioni civiche e partecipative degli abitanti. La trama del verde va letta, dunque, nel saggio, in base alla relazione tensiva tra fenomeni molto diversi che contribuiscono a configurare una morfologia “porosa” costituita anche da spazi aperti differenti. Il saggio esplora, in tal senso, la nascita dei giardini di grandi dimensioni concepiti…

Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4

2012

Ingestion of wheat, barley, or rye triggers small intestinal inflammation in patients with celiac disease. Specifically, the storage proteins of these cereals (gluten) elicit an adaptive Th1-mediated immune response in individuals carrying HLA-DQ2 or HLA-DQ8 as major genetic predisposition. This well-defined role of adaptive immunity contrasts with an ill-defined component of innate immunity in celiac disease. We identify the α-amylase/trypsin inhibitors (ATIs) CM3 and 0.19, pest resistance molecules in wheat, as strong activators of innate immune responses in monocytes, macrophages, and dendritic cells. ATIs engage the TLR4–MD2–CD14 complex and lead to up-regulation of maturation markers a…

GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism

2021

International audience; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of respiratory and cardiovascular diseases, known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes the structural proteins spike (S), envelope (E), membrane (M), and nucleocapsid (N). The receptor-binding domain on the surface subunit S1 is responsible for attachment of the virus to angiotensin (Ang)-converting enzyme 2 (ACE2), which is highly expressed in host cells. The cytokine storm observed in patients with COVID-19 contributes to the endothelial vascular dysfunction, which can lead to acute respiratory distress syndrome, multiorgan failure, alteration in iron homeostasi…

A French and U.S. Comparative Overview of the Critical Concerns of Community College Students and Leaders during the Global Pandemic

2021

International audience

Hall, B.; Tandon, R. i Tremblay, C. (Eds.), (2015). Strengthening Community University Research Partnerships: Global Perspectives Victoria, BC: Unive…

2019

Macrosystem community change in lake phytoplankton and its implications for diversity and function

2023

Aim We use lake phytoplankton community data to quantify the spatio-temporal and scale-dependent impacts of eutrophication, land-use and climate change on species niches and community assembly processes while accounting for species traits and phylogenetic constraints. Location Finland. Time period 1977–2017. Major taxa Phytoplankton. Methods We use hierarchical modelling of species communities (HMSC) to model metacommunity trajectories at 853 lakes over four decades of environmental change, including a hierarchical spatial structure to account for scale-dependent processes. Using a “region of common profile” approach, we evaluate compositional changes of species communities and trait profil…