Search results for "Urine"
showing 10 items of 924 documents
Kuvien maaseutu : maaseutumaisemakuvaston luomat mielikuvat suomalaisesta maaseutukulttuurista
2013
Yläkoulun matematiikan opetuksen eriyttäminen
2014
Jutila, Jonna. Yläkoulun matematiikan opetuksen eriyttäminen. Erityispedagogiikan pro gradu –tutkielma. Jyväskylän yliopiston kasvatustieteiden laitos, 2014. 77 sivua, 4 liitesivua. Tutkimuksen tavoitteena oli kuvata matematiikan oppituntien eriyttämisen vuorovaikutusta ja eriyttämisen ilmenemistä. Lisäksi tarkasteltiin opettajien omia käsityksiä oman opetuksen eriyttämisestä. Tutkimus on osa MUST -projektia (matematiikan oppimisen sosiokulttuurinen tausta, Björn & Vehkakoski 2012, käsikirjoitus tekeillä), jossa matematiikan aineenopettajien opetusta ja heidän käyttämiään matemaattisia käsitteitä tarkastellaan vuorovaikutuksellisesta näkökulmasta. Tutkimuksen aineisto kerättiin kevään 2012 …
Kohti valveutumista ja ajattelun rajoja kriittisen pedagogiikan keinoilla
2018
Katsauksessa pohdimme kriittisen pedagogiikan mahdollisuuksia lisätä opettajaopiskelijoiden kykyä jäsentää yhteiskunnallisten ilmiöiden suhdetta kasvatukseen. Esimerkkinä käytämme Lapset elämänsä valtiaiksi -hanketta, jota Tampereen ammattikorkeakoulun sosionomikoulutuksessa on toteutettu Venäjällä ja Virossa. Siinä sosiokulttuurisen innostamisen avulla, opiskelijoiden oman osallistumisen kautta, pyritään luomaan solidaarisuuteen ja tasa-arvoon kurkottavia yksilöitä. Toiminnan keskeisiä arvoja ovat yhteisöllisyys, osallistuminen, dialogi ja luovuus. Prosessin päämääränä on todellisuuden kriittinen tarkastelu ja siitä kumpuava toiminta. Kriittisen pedagogiikan sovelluksia toteutetaan yliopis…
N-Methyl-β-carboline alkaloids: structure-dependent photosensitizing properties and localization in subcellular domains
2020
N-Methyl-β-carboline (βC) alkaloids, including normelinonine F (1b) and melinonine F (2b), have been found in a vast range of living species playing different biological, biomedical and/or pharmacological roles. Despite this, molecular bases of the mechanisms through which these alkaloids would exert their effect still remain unknown. Fundamental aspects including the photosensitizing properties and intracellular internalization of a selected group of N-methyl-βC alkaloids were investigated herein. Data reveal that methylation of the βC main ring enhances its photosensitizing properties either by increasing its binding affinity with DNA as a biomolecular target and/or by increasing its oxid…
2007
In vivo evaluation of the interaction between the Escherichia coli IGP synthase subunits using the Bacterial Two-Hybrid system
2020
ABSTRACT Histidine biosynthesis is one of the most characterized metabolic routes for its antiquity and its central role in cellular metabolism; indeed, it represents a cross-road between nitrogen metabolism and de novo synthesis of purines. This interconnection is due to the activity of imidazole glycerol phosphate synthase, a heterodimeric enzyme constituted by the products of two his genes, hisH and hisF, encoding a glutamine amidotransferase and a cyclase, respectively. Despite their interaction was suggested by several in vitro experiments, their in vivo complex formation has not been demonstrated. On the contrary, the analysis of the entire Escherichia coli interactome performed using…
Characterization of adenosine receptors in guinea-pig isolated left atria
1989
1. The effects of purinergic stimulation on action potential, force of contraction, 86Rb efflux and 45Ca uptake were investigated in guinea-pig left atria. 2. Adenosine exerted a negative inotropic effect which was antagonized by adenosine deaminase but enhanced by dipyridamole. 3. The negative inotropic effect of adenosine was mimicked by 5'-(N-ethyl)-carboxamido-adenosine (NECA) and the isomers of N6-(phenyl-isopropyl)-adenosine, R-PIA and S-PIA. NECA and R-PIA were about 100 times more potent than adenosine, whereas R-PIA was about 100 times more potent than S-PIA. 4. The inotropic effects of adenosine (in the presence of dipyridamole), NECA, R-PIA and S-PIA were competitively antagonize…
Adrenoceptor-mediated effects on calcium channel currents are antagonized by 5?-(N-ethyl)-carboxamido-adenosine in guinea-pig atrial cells
1992
In guinea-pig atrial myocytes, the effects of the adenosine analogue 5′-(N-ethyl)-carboxamido-adenosine (NECA) in the presence of isoprenaline (ISO) on Ca2+ channel activity were analyzed. Single Ca2+ channel currents were recorded from cell-attached patches by application of several hundred 100 ms depolarizing steps. Under control conditions, burstlike activity of channel openings during some depolarizing steps were followed by variably long periods of quiescence (blank sweeps). During superfusion with ISO (100 nmol/l), ensemble-averaged (mean) current was increased by about 150%. The underlying mechanism was found to be a significant increase in the channel availability, defined as the ra…
Adenosine receptor agonists for promotion of dermal wound healing
2008
Wound healing is a dynamic and complex process that involves a well-coordinated, highly regulated series of events including inflammation, tissue formation, revascularization and tissue remodeling. However, this orderly sequence is impaired in certain pathophysiological conditions such as diabetes mellitus, venous insufficiency, chronic glucocorticoid use, aging and malnutrition. Together with proper wound care, promotion of the healing process is the primary objective in the management of chronic poorly healing wounds. Recent studies have demonstrated that A(2A) adenosine receptor agonists promote wound healing in normal and diabetic animals and one such agonist, Sonedenoson, is currently …
Halogenated Anesthetics Determination in Urine by SPME/GC/MS and Urine Levels Relationship Evaluation with Surgical Theatres Contamination
2014
In this work, a new sensitive analytical method has been developed and evaluated for the determination of the most commonly used gaseous anesthetics, desflurane, sevoflurane, and this latter’s hepatic metabolite hexafluoroisopropanol (HFIP) in the urine. In addition, an evaluation of anesthetics exposition on the urine levels of a small population of surgical operators has been performed and results are briefly discussed.