Search results for "VARIATION"
showing 10 items of 2124 documents
MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review
2021
Background MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. Material and Methods We conducted a systematic search with the following MeSH terms: ‘oral leukoplakia’, ‘carcinoma in situ’, ‘microRNAs’, ‘mouth neoplasms’ and ‘epithelial–mesenchymal transition’ in PubMed/MEDLINE, EMBASE and SpringerLink. Results Fifteen articles were included for analysis, among which in …
A Computational Study on Temperature Variations in MRgFUS Treatments Using PRF Thermometry Techniques and Optical Probes
2021
Structural and metabolic imaging are fundamental for diagnosis, treatment and follow-up in oncology. Beyond the well-established diagnostic imaging applications, ultrasounds are currently emerging in the clinical practice as a noninvasive technology for therapy. Indeed, the sound waves can be used to increase the temperature inside the target solid tumors, leading to apoptosis or necrosis of neoplastic tissues. The Magnetic resonance-guided focused ultrasound surgery (MRgFUS) technology represents a valid application of this ultrasound property, mainly used in oncology and neurology. In this paper
On State Constrained Optimal Shape Design Problems
1987
This paper is concerned with the following optimal design problem with constraints both on the state and on the control: $$MinimizeJ(y,u)$$ (P) subject to $$A\left( u \right)y + \partial \varphi \left( y \right) \mathrel\backepsilon Bu + f,$$ (1.1) $$y \in K,$$ (1.2) $$u \in {U_{ad}}.$$ (1.3)
Contact Shape Optimization
1995
Shape optimization is a branch of the optimal control theory in which the control variable is connected with the geometry of the problem. The aim is to find a shape from an a priori defined class of domains, for wich the corresponding cost functional attains its minimum. Shape optimization of mechanical systems, behaviour of which is described by equations, has been very well analyzed from the mathematical, as well as from the mechanical point of view, see [1], [2], [3] and references therein. The aim of this contribution is to extend results to the case, in which the system is described by the so called variational inequalities. There are two reasons for doing that: 1) The behavior of many…
Precise determination of orbital parameters in system with slowly drifting phases: application to the case of XTE J1807-294
2007
We describe a timing technique that allows to obtain precise orbital parameters of an accreting millisecond pulsar in those cases in which intrinsic variations of the phase delays (caused e.g. by proper variation of the spin frequency) with characteristic timescale longer than the orbital period do not allow to fit the orbital parameters over a long observation (tens of days). We show under which conditions this method can be applied and show the results obtained applying this method to the 2003 outburst observed by RXTE of the accreting millisecond pulsar XTE J1807-294 which shows in its phase delays a non-negligible erratic behavior. We refined the orbital parameters of XTE J1807-294 usin…
Optimal Control for Plate Problems
2003
The variational approach leading to indirect methods Optimal Control Problems is applied to the study of simply supported and clamped plates. A unified approach based on distributed optimal control problems governed by second order elliptic boundary value problems and their penalization is used.
Prevalence and characterization of maxillary sinus septa in a brazilian population
2019
Background The aim of this study was to assess the anatomic aspects of the maxillary sinus septa, by means of computed tomography images, in a Brazilian population. The results might be of clinical significance in sinus lift surgery planning. Material and methods In the study, 123 computed tomographs obtained from a private radiology clinic were used. They were analyzed by a single, trained and calibrated observer in order to evaluate the presence, quantity, localizations, dimensions, orientations and different characteristics in dentate, partially edentulous and completely edentulous individuals of the sinus septa. Results Of the individuals analyzed, 26% had a septum in the maxillary sinu…
Physiological and genomic variations in rice cells recovered from direct immersion and storage in liquid nitrogen
1999
The use of cryoprotectants and slow cooling rates are routine procedures for the cryopreservation of plant cell lines. However, our results with rice (Oryza sativa L., cv. Taipei 309) show that calli can be cryopreserved by direct immersion and stored in liquid nitrogen without any cryoprotection. The efficiency of recovery using this method, as well as a conventional method was generally increased with a previous abscisic acid (ABA) treatment. Following cryopreservation, calli demonstrated some differences with respect to unfrozen calli of the same lines. Thus, resistance to freezing stress (−20°C for 2 h) increased significantly in all lines tested, irrespective of their pre-incubation wi…
A first comparative map of copy number variations in the sheep genome.
2011
article i nfo We carried out a cross species cattle-sheep array comparative genome hybridization experiment to identify copy number variations (CNVs) in the sheep genome analysing ewes of Italian dairy or dual-purpose breeds (Bagnolese, Comisana, Laticauda, Massese, Sarda, and Valle del Belice) using a tiling oligonucleotide array with ~385,000 probes designed on the bovine genome. We identified 135 CNV regions (CNVRs; 24 reported in more than one animal) covering ~10.5 Mb of the virtual sheep genome referred to the bovine genome (0.398%) with a mean and a median equal to 77.6 and 55.9 kb, respectively. A comparative analysis between the identified sheep CNVRs and those reported in cattle a…
A Robustness Approach to Reliability
2012
Reliability of products is here regarded with respect to failure avoidance rather than probability of failure. To avoid failures, we emphasize variation and suggest some powerful tools for handling failures due to variation. Thus, instead of technical calculation of probabilities from data that usually are too weak for correct results, we emphasize the statistical thinking that puts the designers focus on the critical product functions. Making the design insensitive to unavoidable variation is called robust design and is handled by (i) identification and classification of variation, (ii) design of experiments to find robust solutions, and (iii) statistically based estimations of proper safe…