Search results for "VAST"

Defense-related gene expression in two olive cultivars inoculated with Pseudomonas savastanoi pv. savastanoi

2014

Ethyl-eicosapentaenoic acid and carnosine supplementation's effects on cognitive, behavioural and psychophysiological parameters on healthy young sub…

2007

Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer

2020

Abstract Background Immune response against cancer has prognostic impact but its role in gastric cancer is poorly known. The aim of the study was to assess the prognostic significance of immune cell score (CD3+, CD8+), tumour immune escape (PD-L1, PD-1) and immune tolerance (Clever-1). Methods After exclusion of Epstein-Barr virus positive (n = 4) and microsatellite instable (n = 6) tumours, the study included 122 patients with GC undergoing D2 gastrectomy. CD3+ and CD8+ based ICS, PD-L1, PD-1 and Clever-1 expressions were evaluated. Differences in survival were examined using Cox regression adjusted for confounders. The primary outcome was 5-year survival. Results The 5-year overall surviv…

Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for…

2018

IntroductionRoux-en-Y gastric bypass (GBP) is associated with changes in cardiometabolic risk factors and bioavailability of drugs, but whether these changes are induced by calorie restriction, the weight loss or surgery per se, remains uncertain. The COCKTAIL study was designed to disentangle the short-term (6 weeks) metabolic and pharmacokinetic effects of GBP and a very low energy diet (VLED) by inducing a similar weight loss in the two groups.Methods and analysisThis open, non-randomised, three-armed, single-centre study is performed at a tertiary care centre in Norway. It aims to compare the short-term (6 weeks) and long-term (2 years) effects of GBP and VLED on, first, bioavailability…

How they walk the talk : Responsible management education in Finnish business schools

2022

Responsible management education (RME) has become a common initiative in the educational discourse of business schools worldwide. However, little is known about how (non-)engagement with RME in the past influenced the way RME is organised today. We examine this in one of the pioneering countries of RME, Finland, using extensive qualitative research materials. Our results suggest that RME has been embedded with authenticity-driven change (local context and research) since the 1990s. In the late 2000s after the legal educational reforms implemented in Finland, the prestige-driven change (accreditations) began to shape the embedding of RME. In the 2020s, both the authenticity- and prestige-dri…

Aging as a topic in a business magazine : an opportunity or threat for management?

2018

Purpose Recently, research on aging in the work-life context from the perspective of how to manage, support and retain an aging workforce has increased among management scholars, and therefore is contributing to the current societal need to extend work careers. The purpose of this paper is to analyze the articles discussing aging in the work-life context in the Finnish business magazine Talouselämä (Economic Life) during the years 2002–2017. Design/methodology/approach A total of 81 articles were included in the analysis. They were classified into seven themes as a result of a content analysis. Three levels of discussions on aging were identified: societal, organizational and individual. T…

Employee Rhetoric in the Acceptance or Rejection of Corporate Environmentalism

2016

This study explores how employees in a Finnish financial company use rhetorical strategies to accept or reject corporate environmentalism. It is based on a qualitative study in which face-to-face interviews were conducted among 30 employees. The study shows how employees rejected corporate environmentalism by dissociating their employer from polluters or by dissociating environmental values from other values in the financial business. It also shows how they accepted corporate environmentalism by associating it with other business virtues and by associating the employer with polluters. The study identifies rhetorical strategies as a means for employees to construct an understanding of corpor…

The relationship between organizational dissent and workplace freedom of speech: A cross-cultural analysis in Singapore

2017

AbstractThis study is a test of the relationship between organizational dissent and the perception of workplace freedom of speech in Singapore. Through a quantitative analysis of 384 individuals in Singapore, the following was found: articulated dissent and latent dissent are positively correlated with workplace freedom of speech. In addition, multiple analysis of covariance analyses revealed nation of birth exerted considerable influence on articulated dissent, and latent dissent, but not on workplace freedom of speech. The results provide evidence of how nation of birth is related to an individual’s willingness to express dissent. Theoretical and practical implications for research into o…

Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases

2021

Simple Summary Metastasis is the main cause for cancer mortality. The most common metastatic sites of colorectal cancer (CRC) are the liver and lungs. Tumour-infiltrating lymphocytes are recognized as beneficial prognostic factors both in primary and metastatic CRC, but less is known about their reciprocal differences. The aim of our study was to evaluate immune microenvironment and its prognostic value in a series of mismatch proficient (pMMR) CRC with matched liver and lung metastases. The proportion of tumours with high immune cell infiltration together with PD-L1-positivity almost doubled in metastases compared to primary tumours. Our study confirmed the prognostic value of high ICS in …

A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies

2023

The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of oncogenic NRF2 signaling. We identified an immunoevasive phenotype where high NRF2 activity is associated with low interferon-gamma (IFNγ), HLA-I expression and T cell and macrophage infiltration in squamous malignancies of the lung, head and neck area, cervix and esophagus. Squamous NRF2 overactive tumors comprise a molecular phenotype with SOX2/TP63 amplification, TP53 mutation and CDKN2A loss. These immune cold NRF2 hyperactive diseases are a…