Search results for "VIRUS DISEASE"
showing 10 items of 1907 documents
Spread of hepatitis B virus infection among family contacts of asymptomatic HBsAg carriers
1979
Family members of 34 asymptomatic HBsAg carriers were tested for different hepatitis B virus (HBV) markers. Among 67 family members tested 24 (36%) presented signs of a past or ongoing HBV-infection. Spread of HBV-infection was particularly high in those families in which the HBsAg carrier was positive for HBeAg and Dane particle-associated DNA polymerase activity. Non-parenteral “horizontal” transmission of HBV among spouses and brothers and sisters and probably parenteral vertical transmission of HBV from carrier mothers to their infants occurred in approximately the same frequency. Fathers transmitted HBV unfrequently to their offsprings. The results show that the risk to acquire a HBV-i…
Firms’ investment, indebtedness and financial constraints: Size does matter
2022
Abstract This paper provides evidence of the importance of size in explaining the impact of financing conditions on firms´ investment rate. The study makes two main contributions: a) it allows the relationship between indebtedness and firms´ investment to be non-linear; and b) it contrasts whether the impact of indebtedness and the degree of financial restriction differ depending on the size of the company (SME vs large). Results show that while in SMEs indebtedness has a negative impact on investment, there is a threshold beyond which this effect is even larger (based on a debt/assets ratio of 59%). However, in large companies the impact of indebtedness is positive although there is also a…
THE ROLE OF FINANCIAL SUPPORT FOR THE PERFORMANCE AND SURVIVAL OF MICRO-ENTERPRISES
2021
The research was supported by the NATIONAL RESEARCH PROGRAMME “LATVIAN HERITAGE AND FUTURE CHALLENGES FOR THE SUSTAINABILITY OF THE STATE” project “CHALLENGES FOR THE LATVIAN STATE AND SOCIETY AND THE SOLUTIONS IN INTERNATIONAL CONTEXT" (INTERFRAME-LV, Project No.VPP-IZM-2018/1-0005).
Occurrence of hepatocellular carcinoma and decompensation in western european patients with cirrhosis type B
1995
To examine the morbidity of compensated cirrhosis type B, a cohort of 349 Western European, white patients (86% men; mean age, 44 years) with biopsy-proven cirrhosis was followed up for a mean period of 73 months and was studied for occurrence of hepatocellular carcinoma (HCC) and decompensation. At entry into the study all patients were tested for hepatitis B e antigen (HBeAg; 34% of patients were HBeAg-positive) and antibody to hepatitis delta virus (anti-HDV; 20% of patients were anti-HDV-positive); 48% of 252 patients tested were hepatitis B virus (HBV)-DNA-positive. During follow-up HCC developed in 32 (9%) of the 349 patients and decompensation was observed in 88 (28%) of 317 tumor-fr…
The Impact of COVID-19 on the Rent-a-Car Industry
2021
Without any doubt, coronavirus disease slumped global economies in an unparalleled crisis, one of the worst downturns since 2008. COVID-19 not only affected negatively the tourism industry but also other service sectors. To some extent, governments have adopted two different dispositions against the virus. While some nations imposed a strict lockdown, others privilege the consumption and domestic circuits of payment. In its history, the tourism industry has never faced a crisis of this caliber, and its impacts remain unsure even to date. Although the interests and studies evaluating the impact of COVID-19 have captivated the attention of countless scholars, less attention has been given to …
Changes to legal forensic inspections in Sicily during Covid-19
2020
Our institute, in collaboration with the Public Prosecutor’s Office, arranges for cadaveric inspections during a judicial inspection, jointly with the police. With the advent of the Covid-19 pandemic, operating methods have changed. Specifically, we now discuss the cases individually before attending to guarantee the health of operators and citizens
Crisis, pandemia y fragilidades : reflexiones desde un ?balcón sociológico?.
2020
La crisis derivada de la pandemia por COVID-19 en la que se encuentran nuestras sociedades, nos lleva a pensar en la fragilidad o la incertidumbre como piezas fundamentales de ellas, y a reflexionar sobre las consecuencias sociales de esta situación. La relación cotidiana con una situación de confinamiento a la que nunca antes nos habíamos enfrentado, ha hecho resquebrajarse nuestra forma de gestionar el tiempo, de relacionarnos, de trabajar, de estudiar… Todo ello conllevará un nuevo escenario social en el que se sucederán multitud de preguntas a las que la Sociología deberá dar respuesta al tiempo que soluciones para las consecuencias sociales de esta crisis.
Endoplasmic Reticulum Chaperones in Viral Infection: Therapeutic Perspectives
2021
SUMMARY Viruses are intracellular parasites that subvert the functions of their host cells to accomplish their infection cycle. The endoplasmic reticulum (ER)-residing chaperone proteins are central for the achievement of different steps of the viral cycle, from entry and replication to assembly and exit. The most abundant ER chaperones are GRP78 (78-kDa glucose-regulated protein), GRP94 (94-kDa glucose-regulated protein), the carbohydrate or lectin-like chaperones calnexin (CNX) and calreticulin (CRT), the protein disulfide isomerases (PDIs), and the DNAJ chaperones. This review will focus on the pleiotropic roles of ER chaperones during viral infection. We will cover their essential role …
Kinetics of cytomegalovirus (CMV) pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells during episodes of viral DNAemia in allogeneic stem cell tran…
2010
The dynamics of CMV pp65 and IE-1-specific IFNgamma-producing CD8(+) (IFNgamma CD8(+)) and CD4(+) (IFNgamma CD4(+)) T cells and CMV DNAemia were assessed in 19 pre-emptively treated episodes of active CMV infection. Peripheral counts of IFNgamma CD8(+) and IFNgamma CD4(+) T cells inversely correlated with CMV DNAemia levels (P = <0.001 and P = 0.003, respectively). A threshold value of 1.3 cells/microl predicting CMV DNAemia clearance was established for IFNgamma CD8(+) T cells (PPV, 100%; NPV, 93%) and for IFNgamma CD4(+) T cells (PPV, 100%; NPV, 75%). Undetectable T-cell responses were usually observed at the time of initiation of pre-emptive therapy. Either a rapid (within 7 days) or a d…
A QSAR study investigating the potential anti-HIV-1 effect of some acyclovir and ganciclovir analogs
2009
A QSAR study, involving the use of calculated physical-chemical properties (TSAR TM ), and the use of a neural network approach (TSAR TM ), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.