Search results for "VPA"

showing 10 items of 23 documents

Macrophytes in boreal streams: Characterizing and predicting native occurrence and abundance to assess human impact

2016

Abstract Macrophytes are a structurally and functionally essential element of stream ecosystems and therefore indispensable in assessment, protection and restoration of streams. Modelling based on continuous environmental gradients offers a potential approach to predict natural variability of communities and thereby improve detection of anthropogenic community change. Using data from minimally disturbed streams, we described natural macrophyte assemblages in pool and riffle habitats separately and in combination, and explored their variation across large scale environmental gradients. Specifically, we developed RIVPACS-type models to predict the presence and abundance of macrophyte taxa at …

0106 biological sciencesbioassessmentRiffleEcologyEcologyNull model010604 marine biology & hydrobiologyagricultural pressureGeneral Decision SciencesSTREAMSpredictive modelsreference condition010603 evolutionary biology01 natural sciencesMacrophyteRIVPACSRIVPACSBorealHabitatwater framework directiveta1181Environmental scienceEcosystemEcology Evolution Behavior and SystematicsEcological Indicators
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Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid

2021

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficient social interaction and communication besides repetitive, stereotyped behaviours. A characteristic feature of ASD is altered dendritic spine density and morphology associated with synaptic plasticity disturbances. Since microtubules (MTs) regulate dendritic spine morphology and play an important role in spine development and plasticity the aim of the present study was to investigate the alterations in the content of neuronal α/β-tubulin and Tau protein level as well as phosphorylation state in the valproic acid (VPA)-induced rat model of autism. Our results indicated that maternal exposure to VPA indu…

0301 basic medicineDendritic spineHippocampuslcsh:Chemistry0302 clinical medicinePregnancyTubulinPhosphorylationlcsh:QH301-705.5SpectroscopyValproic AcidbiologyERK1/2Chemistryautism spectrum disorders (ASD)valproic acid (VPA)BrainGeneral MedicineImmunohistochemistryComputer Science Applicationsmedicine.anatomical_structureCerebral cortexMaternal ExposurePrenatal Exposure Delayed EffectsFemaleDisease Susceptibilitymedicine.drugSignal Transductionmedicine.medical_specialtyCDK5Tau proteintau ProteinsCatalysisArticleInorganic Chemistry03 medical and health sciencesInternal medicinemental disordersmedicineAnimalsPhysical and Theoretical ChemistryAutistic DisorderMolecular BiologyCyclin-dependent kinase 5GSK-3βValproic AcidOrganic Chemistryα/β-tubulinRatsEnzyme Activation030104 developmental biologyEndocrinologylcsh:Biology (General)lcsh:QD1-999MAP-TauChromatolysisSynaptic plasticitybiology.proteinAkt/mTOR signalling030217 neurology & neurosurgeryBiomarkersInternational Journal of Molecular Sciences
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Thermomineral waters of Greece: geochemical characterization

2020

75 °C). In terms of pH most results vary from 5.5 to 823 °C) ii) warm (23 40 °C) iii) thermal (40 75 °C) and iv) hyperthermal (&gtfew springs show either very low pH (&lt10) proposing serpentinization processes. Regarding TDS concentrations collected waters can be subdivided into low salinity (up to 1.5 g/L) brackish (up to 20 g/L) and saline (up to 43 g/L). The medium high salinities can be justified by mixing with sea water and/or strong waterrock interaction processes. Isotope composition of O and H ranges from 12.7 to +2.7 ‰ SMOW and from 91 to +12 ‰ SMOW respectively and is generally comprised between the Global Meteoric Water Line and the East Mediterranean Meteoric Water Line. Only few water samples show a positive shift for δ18O possibly related to high temperature waterrock interaction processes. Carbon dioxide (18 997000 μmol/mol) or N2 (1100 989000 μmol/mol) or CH4 (&ltMany geothermal areas of Greece are located in regions affected by Miocene or Quaternary volcanism and in continental basins characterised by elevated heat flow. Moreover the majority of them is found along the coast as well as in islands of the Aegean Sea and thus thermal water is often brackish to saline due to marine intrusion into costal aquifer. In the present study almost 300 thermal and cold mineral water samples were collected along the Hellenic territory with their physicochemical parameters (temperature pH electrical conductivity and Eh) and the amount of bicarbonates (titration with 0.1N HCl) being determined in situ. Additionally gases found either in free or dissolved phase were sampled. Both water and gas samples were analysed at the INGVPa laboratories for major ions (Ion Chromatography) silica (Inductively Coupled Plasma Optical Emission Spectrometry) chemical composition of free and dissolved gases (Gas Chromatography) water isotopes (O and H) and carbon and helium isotopes of free and dissolved gases (Mass Spectrometry). The temperature of the investigated waters ranges from 6.5 to 98°C pH from 1.96 to 11.98 whilst Total Dissolved Solids (TDS) from 0.06 to 43 g/L. Based on the temperature parameter waters can be divided into four groups: i) cold (&lt0.5 913000 μmol/mol) are the prevailing gas species found in the studied sites. The δ13CCO2 values ranged from 20.1 to +8.5 ‰ whilst the isotope ratio of He from 0.21 to 6.71 R/RA.4) suggesting interaction with H2Srich gases or very high pH values (&gtSettore GEO/08 - Geochimica E Vulcanologia
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Slavenību iesaistīšanās ASV prezidenta pirmsvēlēšanu periodā. Mailijas Sairusas, Lēdijas Gagas, Bejonses Noulzas un Hilarijas Klintones gadījums – In…

2017

Bakalaura darba tēma ir “Slavenību iesaistīšanās ASV prezidenta pirmsvēlēšanu periodā. Mailijas Sairusas, Lēdijas Gagas, Bejonses Noulzas un Hilarijas Klintones gadījums – Instagram profilu analīze periodā no 1.06.2016 līdz 8.11.2016” Darba mērķis ir noskaidrot kā mūziķes Lēdija Gaga, Bejonsē Noulza un Mailija Sairusa komunicēja ar sekotājiem, lai platformā Instagram aicinātu cilvēkus balsot par Hilariju Klintoni ASV prezidenta vēlēšanās. Darbā analizēts, kā slavenības izvēlētajā laika periodā komunicēja ar auditoriju, lai runātu par vēlēšanām un Hilariju Klintoni. Darbā apskatīta divpakāpju plūsmas teorija, politiskā komunikācija, fanu kults. Izmantotās pētniecības metodes ir vizuālā un te…

Fanu kultsDivpakāpju plūsmas teorijaSlavenībasInstagramKomunikācijas zinātnePolitiskā komunikācija
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Comparative Study of the Effects Exerted by N-Valproyl-L-Phenylalanine and N-valproyl-L-tryptophan on CA1 Hippocampal Epileptiform Activity in Rat

2018

Background: The research on the improvement of epilepsy therapy is constantly growing. Valproyl-LPhenylalanine (VPA-Phen) and N-valproyl-L-tryptophan (VPA-Tryp) were synthesized to increase the antiepileptic efficacy of valproic acid. Methods: VPA-Phen and VPA-Tryp were comparatively tested on CA1 hippocampal epileptiform bursting activity obtained by increasing potassium and lowering calcium and magnesium concentrations in the fluid perfusing rat brain slices. Each slice was treated with a single concentration (0.2, 0.5, 1 mM) of VPA-Phen or VPA-Tryp. Both burst duration and interburst frequency, during and after treatment, were off-line compared with baseline values. For both parameters,…

Male0301 basic medicinePhenylalaninePotassiumchemistry.chemical_elementPharmacologyHippocampal formationCalciumInhibitory postsynaptic potentialHippocampusSettore BIO/09 - Fisiologia03 medical and health sciencesantiepileptic drug0302 clinical medicineDrug DiscoveryN-valproyl-L-tryptophanvalproic acid.medicineAnimalshippocampal epilepsyRats WistarPharmacologyValproic AcidEpilepsyValproyl-L-Phenylalanine (VPA-Phen)Dipeptidesinterictal burstRat brainAmino-acidic derivativeRats030104 developmental biologychemistryAnticonvulsantslipids (amino acids peptides and proteins)030217 neurology & neurosurgerymedicine.drugN-valproyl-L-phenylalanineCurrent Pharmaceutical Design
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Physical activity, aerobic fitness, and brain white matter : Their role for executive functions in adolescence

2020

Highlights • Aerobic fitness level, but not physical activity, is related to white matter properties in the brain. • The relation between physical activity and working memory is moderated by fractional anisotropy (FA) of the corpus callosum. • The FA of the corpus callosum and superior corona radiata moderates the relation between aerobic fitness and working memory.

Malephysical activitySpatial memoryDevelopmental psychologyExecutive functionsExecutive Function0302 clinical medicinenuoretCOGNITIVE CONTROLDWI diffusion-weighted imagingFitnessdiffuusiotensorikuvaus315 Sport and fitness sciencesPLASTICITYFA fractional anisotropyChildOriginal ResearchTBSS Tract-Based Spatial Statisticslcsh:QP351-495White matterCognitionExecutive functionsdiffusion tensor imagingexecutive functionsmurrosikäRD radial diffusivityINTEGRITYfitnessfyysinen kuntomedicine.anatomical_structureDiffusion tensor imagingFemalePsychologyaivotRVP rapid visual information processingwhite matterNeurovetenskaperAD axial diffusivityfractional anisotropyfyysinen aktiivisuusMulti-stage fitness testendocrine systemtoiminnanohjaus (psykologia)AdolescentDISTORTION CORRECTIONMVPA moderate-to-vigorous intensity physical activityPhysical activityTFCE threshold-free cluster enhancementWhite matter03 medical and health sciencesWORKING-MEMORY030225 pediatricsmedicineAerobic exerciseHumansExerciseAgedOBJECTIVE MEASURESMD mean diffusivityWorking memoryPhysical activityNeurosciencesPUBERTAL CHANGESvalkea aineCORPUS-CALLOSUMlcsh:Neurophysiology and neuropsychologySWM patial working memoryVOLUMEMICROSTRUCTURECANTAB Cambridge Neuropsychological Automated Test BatteryMRI magnetic resonance imaging030217 neurology & neurosurgeryFractional anisotropy
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Validity of items assessing self-reported number of breaks in sitting time among children and adolescents

2020

Background: Sedentary behaviour guidelines recommend that individuals should regularly break up sitting time. Accurately monitoring such breaks is needed to inform guidelines concerning how regularly to break up sitting time and to evaluate intervention effects. We investigated the concurrent validity of three &ldquo

Malepsychometricsmedicine.medical_specialtyEveningPsychometricsHealth Toxicology and MutagenesisConcurrent validityCHILDHOODlcsh:MedicineIntervention effectSittingSpearman's rank correlation coefficientArticleTimeScreen Time03 medical and health sciencesScreen time0302 clinical medicinesedentary behaviourmedicineMedicine and Health SciencesHumansactivPAL030212 general & internal medicineASSOCIATIONSSitting Positionchildlcsh:RPublic Health Environmental and Occupational HealthSEDENTARY BEHAVIOR030229 sport sciencesSitting timeHEALTH INDICATORSPHYSICAL-ACTIVITYVDP::Medisinske Fag: 700::Helsefag: 800YOUTHadolescentRELIABILITYsurveys and questionnairesPhysical therapyFemaleSCHOOL-AGED CHILDRENSelf ReportSedentary Behavior
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Die passivischen Ausdrücke der medizinischen Fachsprache

1998

PassivPassivparaphrasenFachsprachen
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Moderate-Vigorous Physical Activity across Body Mass Index in Females : Moderating Effect of Endocannabinoids and Temperament

2014

Altres ajuts: This manuscript was supported by grants from Instituto Salud Carlos III (FIS PI11/210 and CIBERobn). Sarah Sauchelli is recipient of a pre-doctoral Grant (2013-17) by IDIBELL. Jose C. Fernández-García is recipient of a 'Rio Hortega' contract from 'Instituto de Salud Carlos III', Madrid, Spain (CM12/00059). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Endocannabinoids and temperament traits have been linked to both physical activity and body mass index (BMI) however no study has explored how these factors interact in females. The aims of this cross-sectional study were to 1) examine differences…

PhysiologyObesidad:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings]Social SciencesDonesÍndice de masa corporalBlood plasmaBiochemistry:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity [Medical Subject Headings]Body Mass IndexMorbid obesityEndocrinologyFemalesMedicine and Health SciencesHomeostasisPsychologyPublic and Occupational HealthBody mass index (BMI)Big Five personality traitsmedia_commonMultidisciplinaryQRNeurochemistryMiddle AgedLipidsEating disordersEndocannabinoidesPhysiological ParametersHomeostatic MechanismsEating disordersMedicineHarm avoidanceObesitatFemaleBehavioral and Social Aspects of HealthBioelectrical impedance analysisResearch ArticlePersonality:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Arachidonic Acids [Medical Subject Headings]Adultmedicine.medical_specialtyEsfuerzo físicoMujerSciencemedia_common.quotation_subjectObesitat mòrbidaExerciciMotor ActivityBiology:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Personality::Temperament [Medical Subject Headings]Internal medicinemedicine:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Physical Exertion [Medical Subject Headings]HumansÁcidos araquidónicosWomenObesitySports and Exercise MedicineTemperamentTrastorns de la conducta alimentàriaExerciseMotivationBehavior:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids [Medical Subject Headings]Human MovementPhysical activityTemperamentoBody WeightCognitive PsychologyNovelty seekingBiology and Life SciencesModerate-vigorous physical activity (MVPA)NeuroendocrinologyPlasma sanguinimedicine.diseaseObesityMorbid ObesityMetabolismEndocrinology:Check Tags::Female [Medical Subject Headings]Cognitive ScienceTemperamentEnergy MetabolismPhysiological ProcessesBody mass indexNeuroscienceEndocannabinoids
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Predicting the stream macroinvertebrate fauna across regional scales: influence of geographical extent on model performance

2008

AbstractPredictive modeling is used increasingly often in freshwater bioassessment. These models are routinely applied across broad geographical areas, yet the influence of spatial extent on model performance has not been assessed directly. We examined the influence of changing geographical extent on the performance of River InVertebrate Prediction and Classification System (RIVPACS)–type predictive models of benthic macroinvertebrates in boreal headwater streams representative of reference conditions. Separate models were constructed for 2 hierarchical extents: within ecoregions (middle boreal and north boreal) and across ecoregions. We assessed the accuracy and precision of the models usi…

RIVPACSTaxonBorealMean squared errorEcologyBenthic zoneFaunaEnvironmental scienceSTREAMSPhysical geographyAquatic ScienceEcology Evolution Behavior and SystematicsInvertebrateJournal of the North American Benthological Society
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