Search results for "Valg"
showing 10 items of 48 documents
Monitoring of Trough Plasma Ganciclovir Levels and Peripheral Blood Cytomegalovirus (CMV)-Specific CD8 + T Cells To Predict CMV DNAemia Clearance in …
2014
ABSTRACT It is uncertain whether monitoring plasma ganciclovir (GCV) levels is useful in predicting cytomegalovirus (CMV) DNAemia clearance in preemptively treated allogeneic stem cell transplant recipients. In this observational study, including 13 episodes of CMV DNAemia treated with intravenous (i.v.) GCV or oral valganciclovir, we showed that monitoring trough plasma GCV levels does not reliably predict response to therapy. Rather, immunological monitoring (pp65 and immediate-early [IE]-1-specific gamma interferon [IFN-γ]-producing CD8 + T cells) appeared to perform better for this purpose.
Posterior tibial tendon dysfunction: Clinical and magnetic resonance imaging findings having histology as reference standard.
2017
Abstract Objective To investigate the correlation between MRI, clinical tests, histopathologic features of posterior tibial tendon (PTT) dysfunction in patients with acquired adult flatfoot deformity surgically treated with medializing calcaneal osteotomy and flexor digitorum longus tendon transposition. Materials and methods Nineteen patients (11 females; age: 46 ± 15 year, range 18–75) were pre-operatively evaluated using the single heel rise (HR) and the first metatarsal rise (FMR) sign tests. Two reviewers graded the PTT tears on a I–III scale and measured the hindfoot valgus angle on the pre-operative MRI of the ankle. The specimens of the removed portion of PTT were histologically ana…
Effect of long-term prophylaxis in the development of cytomegalovirus-specific T-cell immunity in D+/R- solid organ transplant recipients.
2015
Background This study aimed to characterize the dynamics of acquisition of cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) in CMV donor positive/recipient negative solid organ transplant (SOT) patients receiving long-term antiviral prophylaxis, and to determine whether development of CMI confers protection against CMV disease. Methods A prospective multicenter study was conducted in Spain from September 2009 to September 2012. Whole blood specimens were prospectively collected at 30, 90, 120, 200, and 365 days after SOT, and CMI was determined by enumeration of CMV pp65 and IE-1-specific CD69+/interferon-γ-producing CD8+ and CD4+ T cells by flow cytometry for intracellular cytok…
Plantar pressures determinants in mild Hallux Valgus.
2010
While podobarometric techniques have been applied to the study of pressures in Hallux Valgus (HV), little is known about its clinical and radiological determinants. So, the aim of the present study was to determine the plantar pressure pattern in participants with mild HV, comparing to a control group, and their clinical and anthropometric determinants. Biofoot/IBV(®) in-shoe system was used to evaluate 79 participants with mild HV. Computerized measurements of the 1st intermetatarsal angle (IMA) and the hallux abductus angle (HAA) were made on antero-posterior radiographs. The clinical outcome was assessed using the AOFAS score. The dependent baropodometric variables and the independent cl…
Cytomegalovirus prevention strategies in seropositive kidney transplant recipients: an insight into current clinical practice
2015
Producción Científica
Variable pulmonary manifestations in Chitayat syndrome: Six additional affected individuals
2020
Hand hyperphalangism leading to shortened index fingers with ulnar deviation, hallux valgus, mild facial dysmorphism and respiratory compromise requiring assisted ventilation are the key features of Chitayat syndrome. This condition results from the recurrent heterozygous missense variant NM_006494.2:c.266A>G; p.(Tyr89Cys) in ERF on chromosome 19q13.2, encoding the ETS2 repressor factor (ERF) protein. The pathomechanism of Chitayat syndrome is unknown. To date, seven individuals with Chitayat syndrome and the recurrent pathogenic ERF variant have been reported in the literature. Here, we describe six additional individuals, among them only one presenting with a history of assisted ventil…
Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoG…
2019
This multicenter/multinational, open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat-dose avalglucosidase alfa (neoGAA), a second-generation, recombinant acid α-glucosidase replacement therapy, in late-onset Pompe disease (LOPD). Patients ≥18 years, alglucosidase alfa naïve (Naïve) or previously receiving alglucosidase alfa for ≥9 months (Switch), with baseline FVC ≥50% predicted and independently ambulatory, received every-other-week avalglucosidase alfa 5, 10, or 20 mg/kg over 24 weeks. 9/10 Naïve and 12/14 Switch patients completed the study. Avalglucosidase alfa was well-tolerated; no deaths…
Dvīņu pilsētu-Valkas un Valgas-pārrobežu sadarbība
2017
Kopš Šengenas zonas paplašināšanās Eiropas Savienības dalībvalstu robežu funkcijas ir mainījušās. Ir attīstījušās jaunas politiskās sadarbības formas starp nacionālajām robežām, un robežas kļuvušas atvērtākas. Maģistra darba mērķis ir noskaidrot un novērtēt līdzšinējo pārrobežu sadarbību starp dvīņu pilsētām uz Latvijas un Igaunijas robežas un atklāt aspektus, kas abām dvīņu pilsētām savā pārrobežu sadarbībā būtu jāuzlabo. Lai sasniegtu maģistra darba mērķi, tika izvirzīti vairāki uzdevumi, tostarp izpētīt pārrobežu sadarbību starp dvīņu pilsētām – Valku un Valgu, noskaidrot pārrobežu sadarbības labos piemērus un problēmas, kā arī izstrādāt priekšlikumus Valkas un Valgas pārrobežu sadarbība…
973 Knee control and jump-landing technique in young basketball and floorball players
2016
Background Poor knee alignment is associated with increased loading of the joints, ligaments and tendons, and may increase the risk of injury. The study purpose was to compare differences in knee kinematics between basketball and floorball players during a vertical drop jump (VDJ) task. We wanted to investigate whether basketball players, whose sport includes frequent jump-landings, exhibited better knee control compared with floorball players, whose sport involves less jumping. Methods Players (aged 12–21 years) were recruited from six basketball and floorball clubs of the Tampere City district, Finland. Complete data was obtained from 173 basketball and 141 floorball players. Peak knee va…
Sub specie æternitatis: the role of the ruin and the ancient in the process of architectural renewal between metamorphosis and resurgence
2022
Composing new works of architecture inspired by vestiges from antiquity or archaeology. The reflections and the case study which will be proposed, pertaining to a recent design experiment for the archaeological area and Antiquarium of Tyndaris, are dedicated to this theme. Over and above any charm exerted by such places, by landscapes in which the ruins appear identical in substance and which sometimes manifest themselves as “sub specie æternitatis”, there are reasons linked to the very profession of architect and to the gashes in the crucible of controversies around the role of history in its contentious relationship with architectural design. That apart, the aporias revealed by Michel Fou…