Search results for "Valine"
showing 10 items of 85 documents
Thermal Isomerization Mechanism in Dronpa and Its Mutants.
2016
The photoswitching speed of the reversibly switchable fluorescent proteins (RSFPs) from the family of green fluorescent proteins (GFPs) changes upon mutation which is of direct importance for various high-resolution techniques. Dronpa is one of the most used RSFPs. Its point mutants rsFastLime (Dronpa V157G) and rsKame (Dronpa V157L) exhibit a striking difference in their photoswitching speed. Here the QM/MM on-the-fly string method is used in order to explore the details of the thermal isomerization mechanism. The four principal ways in which isomerization may occur have been scrutinized for each of the three proteins. It has been shown that thermal isomerization occurs via a one-bond-flip…
Synthesis of optically pure alkynols
1993
Abstract (R,S)-1-alkylprop-2-yn-1-ols have been separated by a 2-step procedure, esterification with N-p-tosyl-(L)-phenylalanine (or valine), recrystallisation of the diastereomeric esters from ethanol/hexane and saponification of the optically pure esters.
CCDC 742170: Experimental Crystal Structure Determination
2009
Related Article: C.H.Gorbitz, K.Rissanen, A.Valkonen, A.Husabo|2009|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|65|o267|doi:10.1107/S0108270109014309
CCDC 734753: Experimental Crystal Structure Determination
2010
Related Article: M.C.Semencic, D.Siebler, K.Heinze, V.Rapic|2009|Organometallics|28|2028|doi:10.1021/om801163s
CCDC 1493130: Experimental Crystal Structure Determination
2016
Related Article: Thais Grancha, Marta Mon, Jesus Ferrando-Soria, Donatella Armentano, Emilio Pardo|2016|Cryst.Growth Des.|16|5571|doi:10.1021/acs.cgd.6b01052
CCDC 734752: Experimental Crystal Structure Determination
2010
Related Article: M.C.Semencic, D.Siebler, K.Heinze, V.Rapic|2009|Organometallics|28|2028|doi:10.1021/om801163s
CCDC 1051240: Experimental Crystal Structure Determination
2015
Related Article: S. Nicholas|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|o216|doi:10.1107/S205698901500393X
Surface properties of valine-gramicidin A at the air-water interface
1996
Abstract Fluorescence microscopy, X-ray reflectivity and ellipsometry have been applied to the study of a monolayer of valine-gramicidin A (VGA) at the air-water interface to obtain insight into the conformation and orientation of VGA, and to clarify the shoulder observed in its π - A curve (12.5–16 mN m −1 , 240 – 175 A 2 molecule −1 ). At low molecular areas, the X-ray reflectivities are consistent with formation of a single layer of tubular-shaped dimers. Fluorescence microscopy yielded homogeneous pictures suggesting that on the macroscopic scale the shoulder cannot be attributed to domain formation. Thicknesses calculated from the ellipsometric isotherm are consistent with the X-ray da…
Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
2014
Dietary restriction extends longevity in organisms ranging from bacteria to mice and protects primates from a variety of diseases, but the contribution of each dietary component to aging is poorly understood. Here we demonstrate that glucose and specific amino acids promote stress sensitization and aging through the differential activation of the Ras/cAMP/PKA, PKH1/2 and Tor/S6K pathways. Whereas glucose sensitized cells through a Ras-dependent mechanism, threonine and valine promoted cellular sensitization and aging primarily by activating the Tor/S6K pathway and serine promoted sensitization via PDK1 orthologs Pkh1/2. Serine, threonine and valine activated a signaling network in which Sch…
Self-assembly properties of bile acid derivatives of L-cysteine, L-valine and L-serine alkyl esters
2012
Comprehensive self-assembly studies for nine bile acid amides of amino acid esters are reported. The number of the hydroxyl groups attached to the steroidal skeleton and the character of the amino acid ester moiety were used as variables when examining the self-assembly properties of the compounds. Two of the compounds were shown to undergo self-assembly leading to organogelation. In addition, preliminary self-assembly studies in aqueous mixtures of polar organic solvents were conducted. Microscopic methods (optical microscopy and scanning electron microscopy) were utilised in order to gain a deeper insight into the self-assembled structures. Furthermore, single-crystal X-ray structures for…