Search results for "Valuation"

showing 10 items of 2494 documents

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents.

2019

Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding the biochemical basis of mechanisms responsible for enzyme selectivity and antiproliferative effects has renewed the interest in antifolates for cancer chemotherapy and prompted the medicinal chemistry community to develop novel and selective human DHFR inhibitors, thus leading to a new generation of DHFR inhibitors. This work summarizes the mechanism of action, chemical, and anticancer profile of the DHFR inhibitors discovered in the last six years. New strategies in DHFR drug discovery are also provided, …

AntifungalCancer chemotherapymedicine.drug_classDrug Evaluation Preclinicaldihydrofolate reductase (DHFR) enzymePharmaceutical ScienceAntineoplastic AgentsComputational biologyReview01 natural scienceshybrid compoundsAnalytical Chemistrylcsh:QD241-44103 medical and health sciencesStructure-Activity RelationshipFolic Acidlcsh:Organic chemistryheterocyclic compoundsNeoplasmsDihydrofolate reductaseparasitic diseasesDrug DiscoverymedicineAnimalsHumansPhysical and Theoretical Chemistry030304 developmental biology0303 health sciencesHeterocyclic compoundbiology010405 organic chemistryDrug discoveryOrganic ChemistryDHFR inhibitors as anticancer agentSettore CHIM/08 - Chimica Farmaceutica0104 chemical sciencesDHFR drug discoveryTetrahydrofolate DehydrogenaseMechanism of actionChemistry (miscellaneous)Settore CHIM/03 - Chimica Generale E InorganicaDHFR inhibitors as anticancer agentsbiology.proteinMolecular MedicineFolic Acid Antagonistsmedicine.symptomMolecules (Basel, Switzerland)
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In vitro antifungal properties of mouthrinses containing antimicrobial agents

1997

The purpose of this study was to investigate the in vitro antifungal properties of seven commercial mouthrinses containing antimicrobial agents. These included cetylpyridinium chloride (CPC), chlorhexidine digluconate (CHX), hexetidine (HEX), sanguinarine (SNG), and triclosan (TRN). The minimum fungicidal concentration (MFC) against six species of yeasts was determined by a broth macrodilution method. The kill-time of mouthrinses at half the concentration of the commercial formulations was also determined. MFCs were achieved with each mouthrinse, except the SNG-containing mouthrinse, against all the organisms being tested. However, the CPC-containing mouthrinse appeared more active than the…

AntifungalTime FactorsAntifungal Agentsmedicine.drug_classColony Count MicrobialMouthwashesCetylpyridiniumSaccharomyces cerevisiaeHexetidineCetylpyridinium chlorideMicrobiologychemistry.chemical_compoundAlkaloidsCandidiasis OralCandida albicansmedicineHumansSanguinarineMinimum fungicidal concentrationFood scienceHexetidine/therapeutic useFungal diseases/prevention and controlCandidaBenzophenanthridinesClinical Trials as TopicChlorhexidineSanguinarine/therapeutic useFungiHexetidineIsoquinolinesAntimicrobialTriclosan/therapeutic useTriclosanIn vitroTriclosanchemistryEvaluation Studies as TopicCetylpyridinium chloride/therapeutic useChlorhexidine/therapeutic useAnti-Infective Agents LocalPeriodonticsMouthrinses/therapeutic use
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Revista electrónica de investigación y evaluación educativa

2006

The investigation results are presented: "An investigation or research about the most relevant variables from the student’s point of view which influence the general opinion about the teacher’s performance in the Universidad Autonoma de Occidente". The problems about the influence from the students perception in evaluating their teachers is taken on from two complementary perspectives: The first constitutes the qualitative analysis which has as a support the group interviews realized in each one of the academic programs. The second involves the quantitative analysis based on multivariate statistic tools. These perspectives allow elaborating a model to establish the grade of relevance each o…

Análisis CuantitativoUniversityUniversidadAnálisis CualitativoEvaluaciónDesempeño DocenteQuantitative AnalysisStudent Perceptionslcsh:LB5-3640conducta del profesorEducationevaluación del profesorlcsh:Theory and practice of educationanálisis cualitativoTeacher PerformancePercepciones EstudiantilesStudent Perceptions Evaluation Quantitative Analysis Qualitative Analysis Teacher Performance UniversityQualitative AnalysisEvaluationuniversidad
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Anàlisi crítica d’aplicacions de lectura per a infants: paràmetres i indicadors

2018

Les aplicacions de lectura digital infantil han evolucionat considerablement al llarg dels últims anys. Tanmateix, segueixen sent les grans oblidades en informes i estadístiques sobre la producció editorial i més encara dins del sector digital, cosa que origina un fenomen d’infoxicació en què el mediador es troba amb pocs criteris que faciliten la selecció d’aquest nou tipus de continguts. Aquesta investigació presenta els resultats de l’anàlisi de tretze aplicacions de lectura en les seues dimensions de forma i contingut. Alhora, s’hi observen trets com ara el mode d’adquisició, la privacitat, l’organització de continguts o la personalització. Finalment, reflexionarem sobre l’adequació del…

Aplicaciones de lecturaLinguistics and LanguageAplicacions de lecturaReading apps assessmentAvaluación de aplicaciones de lecturaLiterature and Literary TheoryLinguistique appliquéeÉvaluation des applications de lecturelectura digital infantil; aplicaciones de lectura; indicadores de evaluación de apps; avaluación de aplicaciones de lecturaLanguage and LinguisticsEducationLectura digital infantilchildren’s digital literature; reading apps; apps evaluation indicators; reading apps assessmentindicadors d’avaluació d’appsavaluació d’aplicacions de lecturaaplicacions de lecturaApps evaluation indicatorslectura digital infantil; aplicacions de lectura; indicadors d’avaluació d’apps; avaluació d’aplicacions de lecturaAvaluació d'aplicacions de lecturaIndicadores de evaluación de appsApplied linguisticslectura digital infantilLC8-6691Language and LiteraturePSpecial aspects of educationIndicateurs d'évaluation des applicationsReading appsIndicadors d'avaluació d'appsLecture digitale des enfantsChildren's digital literatureApplications de lectureLingüística aplicadalecture digitale des enfants ; applications de lecture ; indicateurs d'évaluation des applications ; évaluation des applications de lectureBellaterra: journal of teaching and learning language and literature
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Appraisals in Italy Identity, contents, prospects

2018

The paper presents the results of a wide field research concerning the teaching of appraisal studies in the courses of Architecture and Engineering in Italian universities. This general report, including critical observations and interpretations, provides the basis for strategies to increase the presence and impact of appraisal studies. The aim is to spread the personal and professional awareness that the estimative sensibility is a key element for the knowledge and planning of the city and the territory. The paper is divided into three coalescing parts. The first highlights the presence of appraisal teaching in different universities and courses of study, and answers the questions: from wh…

Appraisal and evaluationtrainingIdentityTeachingSettore ICAR/22 - EstimoProfession
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A multicenter study on the appropriateness of hospitalization in obstetric wards: application of Obstetric Appropriateness Evaluation Protocol (Obste…

2015

The cross-sectional study has been based on the implementation of the Obstetric Appropriateness Evaluation Protocol (OAEP) in seven hospitals to determine inappropriate hospital admissions and days of stay. The outcomes were: inappropriateness of admission and "percentage of inappropriateness" for one hospitalization. A total number of 2196 clinical records were reviewed. The mean percentage of inappropriateness for hospitalization was 22%. The percentage of inappropriateness for the first 10 d of hospitalization peaked in correspondence of the fourth (42%). The logistic regression model on inappropriated admission reported that emergency admission was a protective factor (OR = 0.4) and to …

Appropriateness evaluation protocol appropriateness of hospital use inappropriateness obstetricsAdultmedicine.medical_specialtyProtective factorappropriateness of hospital useLogistic regressionPediatricsRegional Health PlanningObstetrics and gynaecologyPregnancyAppropriatenesse valuation protocolAppropriateness evaluation protocol; Appropriateness of hospital use; Inappropriateness; ObstetricsHumansMulticenter Studies as TopicMedicineAppropriateness evaluation protocolRisk factorHospitals TeachingObstetrics and Gynecology Department HospitalinappropriatenessobstetricsEmergency admissionbusiness.industryObstetrics and GynecologyPerinatology and Child HealthLength of StayHospitalizationCross-Sectional StudiesOutcome and Process Assessment Health CareItalyMulticenter studyAppropriateness evaluation protocol; appropriateness of hospital use; inappropriateness; obstetrics; Pediatrics Perinatology and Child Health; Obstetrics and GynecologyPediatrics Perinatology and Child HealthEmergency medicineAppropriatenesse valuation protocol; appropriateness of hospital use; obstetrics; inappropriatenessFemalebusinessClinical recordThe Journal of Maternal-Fetal & Neonatal Medicine
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Evaluación de las actividades realizadas mediante la metodología de Aprendizaje Basado en Problemas

2020

[ES] La metodología de Aprendizaje Basado en Problemas (ABP) requiere un enfoque de evaluación en el que se evalúen una serie de competencias específicas y transversales. Esta evaluación debe de tener un carácter formativo que permita a los estudiantes identificar y corregir los errores a tiempo. Por lo tanto, es necesario disponer de herramientas para poder evaluar apropiadamente los resultados de aprendizaje y las competencias establecidas. En la asignatura de Corrosión de segundo de Máster de Ingeniería Química, el ABP se ha evaluado a través de un informe a entregar tras cada sesión de ABP, en donde se recogen las principales conclusiones tras la resolución cooperativa del problema plan…

Aprendizaje basado en problemasInnovación educativaCoevaluaciónProblem-based learningSelf-assessment toolsCo-assessmentRubricsRubric based evaluationHerramientas de autoevaluaciónEducación superiorRúbricasProblem-based learning (PBL) methodologyEnseñanza superiorTecnologías y educación
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Las competencias básicas en la nueva generación de estudiantes universitarios: Una experiencia de Innovación

2017

[EN] This contribution presents an innovative teaching experience dedicated to developing core competencies in the university student by activating educational practices and evaluation procedures that seek to promote and maximize various competitions. This experiencie has been implemented in different degrees of the University of Valencia during the academic years 2011-12, 2012-13, 2013-14 and 2014-15. Participating in the study 1285 students through accidental sampling accessibility. After developing a survey methodology based on descriptive-exploratory analyzes data collected allow us to know what is the degree of control perceived by university students around the following core competen…

AprendizajeEvaluaciónhabilidadSkillsestudiante universitarioaprendizajeevaluaciónLUniversity studentsEducationTeaching method innovationsHabilidadLearningEstudiante universitarioInnovación pedagógicainnovación pedagógicaEvaluationRed U
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Las competencias básicas en la nueva generación de estudiantes universitarios: Una experiencia de Innovación.

2017

[EN] This contribution presents an innovative teaching experience dedicated to developing core competencies in the university student by activating educational practices and evaluation procedures that seek to promote and maximize various competitions. This experiencie has been implemented in different degrees of the University of Valencia during the academic years 2011-12, 2012-13, 2013-14 and 2014-15. Participating in the study 1285 students through accidental sampling accessibility. After developing a survey methodology based on descriptive-exploratory analyzes data collected allow us to know what is the degree of control perceived by university students around the following core competen…

Aprenentatge Aptitud per a l'habilidad050801 communication & media studies0508 media and communicationsestudianteTeaching method innovationsAprenentatgeHabilidadLearningEnsenyament universitariEvaluationAprendizajeEvaluaciónSkills05 social sciencesaprendizaje050301 educationGeneral MedicineevaluaciónEducació InvestigacióUniversidad de ValenciaUniversity studentsEstudiante universitarioInnovación pedagógicainnovación pedagógica0503 education
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Identification des compétences à l'école élémentaire :une approche empirique à partir des évaluations institutionnelles

2007

Cet article propose une analyse des résultats des élèves aux évaluations nationales, l’objectif étant de mieux comprendre comment les acquisitions se structurent à l’école primaire. L’intérêt de cette démarche réside principalement dans l’identification de compétences dont la maîtrise est essentielle à la réussite scolaire. L’approche choisie pour traiter la question est résolument empirique et se base sur l’examen des relations statistiques entre les items. Elle permet de répondre à plusieurs questions susceptibles d’intéresser les chercheurs en éducation, mais aussi les acteurs engagés, à différents degrés, dans le pilotage et la gestion pédagogique de l’enseignement primaire. Les évaluat…

AquisiçõesSocial Sciences and Humanitiescompétencesescola elementarévaluation[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationItemNational surveysAssessmentCompétenceprimary schoolNational Competency Testsécole primaireavaliaçãoitensPrimary educationEvaluationSkills[ SHS.EDU ] Humanities and Social Sciences/EducationGeneral MedicineAcquisitionEcole primaireAcquisitionsSciences Humaines et SocialesEvaluation nationaleitemscompetências
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