Search results for "Values."
showing 10 items of 1353 documents
Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors.
2013
Luciferase reporter assays are commonly used in high-throughput screening methods. Here, we report new firefly luciferase (FLuc) inhibitors based on 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles, which showed up as "false positives" in a luciferase reporter gene-based assay for nuclear receptor antagonists. The inhibition was shown to be noncompetitive for both natural enzyme substrates (d-luciferin and ATP) and selective to FLuc and proven to arise from a direct interaction between the enzyme and the inhibitor. Of the 63 evaluated compounds, 28 showed significantly better inhibition potency than the well-known inhibitor resveratrol (IC(50) = 59 nM), with fi…
The European Courts and the Security Council: Between "Dédoublement Fonctionnel" and Balancing of Values
2009
The recent case law of various international tribunals facing questions related to UN Security Council resolutions shows the clear tendency to grant primacy to the UN legal order. This trend, far from being well founded on formal arguments, appears to be a tribute to a legal order perceived as superior, and, at the same time, is revealing of the ‘value oriented’ approach followed by the courts. Such an approach can be categorized from a theoretical perspective in the light of Scelle's theory of relations between legal orders, whereby the courts implement in their respective legal orders values stemming from the UN legal order. Various critical remarks can be advanced in relation to this att…
Effect of sulfur dioxide on mucociliary activity and ciliary beat frequency in guinea pig trachea
1994
The effects of 30 min exposure to sulfur dioxide on mucociliary activity (MCA) and ciliary beat frequency (CBF) were studied in 31 guinea pig tracheas. MCA was measured by recording the light reflected from ciliated mucous membranes using an infrared bar code reader. CBF of single ciliated cells obtained by brushing was measured with phase-contrast microscopy. Each tracheal sample was exposed to SO2 at concentrations ranging from 2.5 to 12.5 ppm, or to air for control purposes. MCA and CBF were measured before and immediately after gas exposure. A reduction in mean MCA of 63% (P = 0.0007) and statistically insignificant changes in CBF (P > 0.05) were recorded at concentrations of 2.5 PPM SO…
Effects of dopamine infusion on plasma catecholamines in preterm and term newborn infants.
1991
Newborn infants (21 preterm and 13 term) received dopamine infusions at a low (2.5-3.4 micrograms/kg per min) and/or high (5-10 micrograms/kg per min) infusion rate and changes in plasma catecholamines were monitored. The mean baseline values for dopamine, noradrenaline and adrenaline were between 240 and 560, 125 and 144 and 62 and 82 pg/ml, respectively. During low-rate infusion of dopamine, there was a significant increase in plasma dopamine (20-100 fold), noradrenaline (three- to five-fold) and adrenaline (threefold). Administration of dopamine at the high rate resulted in an even larger increase in the plasma catecholamines (dopamine, 100-300 fold; noradrenaline, seven- to eightfold; a…
Background levels and baseline values of available heavy metals in Mediterranean greenhouse soils (Spain)
2011
Abstract This study determines extractable levels of Cd, Cu, Pb, Zn, Ni and Co in western Almeria (Spain) greenhouse surface soil horizons using EDTA solution, which is identified as the fraction available for organisms and plants. It also establishes background levels, geochemical baseline concentration and reference values (RV), and investigates the possible relationships between soil properties and elemental concentrations. The results show that the soil concentration of these extractable heavy metals was high as those reported by other authors for Spanish agricultural soils. The available RV concentrations obtained (mg kg −1 ) were: Cd 0.17, Cu 1.6, Pb 13.8, Zn 5.0 Ni 1.7 and Co 2.9. Us…
A comparative quantitative & qualitative assessment in orthodontic treatment of white spot lesion treated with 3 different commercially available mat…
2019
Background To comparatively evaluate the esthetic improvement of white-spot lesions (WSLs) treated by: BiominF, CPP-ACP paste with fluoride & ICON resin infiltration, using Spectrophotometer & Diagnodent. Material and Methods The study was done using 72 sound permanent extracted premolars, divided into four groups (18 teeth per group). After taking the ethical approval the study was commenced. WSLs were created on human premolars and randomly assigned to four groups: Group A: Artificial Saliva, Group B: CPP-ACP with fluoride, Group C: BiominF, Group D: Resin infiltration (Icon). The color change (∆E) of each specimen was measured with a Spectrophotometer (VITA Easy Shade Compact), and fluor…
Valores personales en el baloncesto de formación y su relación con el bienestar y la intención futura de práctica a través de la motivación
2019
Tomando como marco teórico la teoría de los valores humanos (Schwartz, 1992; Schwartz et al., 2012), y la teoría de la autodeterminación (Deci y Ryan, 1985, 2000), el objetivo del estudio consistió en poner a prueba un modelo, en una muestra de 115 jugadores jóvenes de baloncesto ( M edad = 13.98, DT = 0.13), en el que se hipotetizó que los diferentes tipos de motivación (motivación autónoma, controlada y no motivación) actuarían como mediadores de la relación entre los va lores informados por los jugadores (auto - trascendencia, conservación, auto - promoción y apertura al cambio) y los indicadores de bienestar (vitalidad subjetiva y afectos positivos), así como con la intención futura de …
Equations-of-motion approach to the spin-12Ising model on the Bethe lattice
2006
We exactly solve the ferromagnetic spin- 1/2 Ising model on the Bethe lattice in the presence of an external magnetic field by means of the equations of motion method within the Green's function formalism. In particular, such an approach is applied to an isomorphic model of localized Fermi particles interacting via an intersite Coulomb interaction. A complete set of eigenoperators is found together with the corresponding eigenvalues. The Green's functions and the correlation functions are written in terms of a finite set of parameters to be self-consistently determined. A procedure is developed that allows us to exactly fix the unknown parameters in the case of a Bethe lattice with any coor…
Combined heterologies for monoclonal antibody-based immunoanalysis of fluxapyroxad
2018
Nowadays, instrumental methodologies and rapid bioanalytical techniques complement each other for the analysis of toxic chemical compounds. Fluxapyroxad was commercialized a few years ago as a fungicide and today it is being used worldwide to control a variety of pests. In the present study, the development of monoclonal antibody-based immunochemical methods for the analysis of this chemical in food samples was evaluated for the first time. Novel haptens were synthesized and protein bioconjugates were prepared. High-affinity and specific monoclonal antibodies to fluxapyroxad were generated from two haptens with alternative linker tethering sites. Haptens with linker site heterology and a st…
Evaluation of B-cell secretion and peripheral insulin resistance during pregnancy and after delivery in gestational diabetes mellitus with obesity
1988
Nine pregnant women with gestational diabetes mellitus (GDM) were studied. Six normal pregnant women and six normal nonpregnant women were evaluated as control groups. All the women underwent oral glucose tolerance test and glucose clamp during the third trimester of pregnancy and two months after delivery. During OGTT, glucose, C-peptide and insulin plasma levels were determined. C-peptide and insulin values in the late phase of OGTT were higher during pregnancy than after delivery in both groups. In gestational diabetic women, the M-value in the second steady-state during glucose clamp was lower than in controls, both during pregnancy and after delivery. Nevertheless, in both groups the M…