Search results for "Variant"
showing 10 items of 1267 documents
Concordance and Clinical Significance of Uncommon Variants of Bladder Urothelial Carcinoma in Transurethral Resection and Radical Cystectomy Specimens
2014
To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens. METHODS Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impac…
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocar…
2014
[Background] The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.
Differential Clinicopathological Risk and Prognosis of Major Papillary Thyroid Cancer Variants
2015
et al.
Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies
2012
Background— Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Methods and Results— Continuous ABI and PAD (ABI ≤0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the ≈2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fi…
The association of variants in PNPLA3 and GRP78 and the risk of developing hepatocellular carcinoma in an Italian population
2016
// Daniele Balasus 1, * , Michael Way 2, * , Caterina Fusilli 3 , Tommaso Mazza 3 , Marsha Y. Morgan 2 , Melchiorre Cervello 4 , Lydia Giannitrapani 1 , Maurizio Soresi 1 , Rosalia Agliastro 5 , Manlio Vinciguerra 2, 6 , Giuseppe Montalto 1, 4 1 Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy 2 Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, UK 3 IRCCS Casa Sollievo della Sofferenza, Bioinformatics Unit, San Giovanni Rotondo (FG), Italy 4 Institute of Biomedicine and Molecular Immunology, National Research Council (C.N.R.), Palermo, Italy 5 Immunohematology and Trans…
Possible Clinical Implications of Geographic Differences in Prevalence of Double Transverse Foramen
2019
The double transverse foramen (DBLTF) is a cervical spine anatomic variant. Current literature has presented prevalence values of DBLTF in Caucasian Mediterranean subjects that seem to be higher than those observed in other samples of subjects. Therefore we aimed to test if Caucasian Mediterranean subjects present a higher prevalence of the DBLTF than sub-Saharan African subjects.We analyzed the presence of DBLTF in cervical spines of 100 skeletons from Caucasian Mediterranean subjects and 91 skeletons from sub-Saharan African subjects, resulting in a total of 1337 cervical vertebrae having been studied.No DBLTF was found in vertebrae C1, C2, and C3. The pattern of prevalence observed in al…
Detecting multiple copies in tampered images
2010
Copy-move forgeries are parts of the image that are duplicated elsewhere into the same image, often after being modified by geometrical transformations. In this paper we present a method to detect these image alterations, using a SIFT-based approach. First we describe a state of the art SIFT-point matching method, which inspired our algorithm, then we compare it with our SIFT-based approach, which consists of three parts: keypoint clustering, cluster matching, and texture analysis. The goal is to find copies of the same object, i.e. clusters of points, rather than points that match. Cluster matching proves to give better results than single point matching, since it returns a complete and co…
A new hyperelastic model for anisotropic hyperelastic materials with one fiber family
2016
International audience; The main goal of this study is to propose a practical application of a new family of transverse anisotropic invariants by designing a strain energy function (SEF) for incompressible fiber-reinforced materials. In order to validate the usability and creativeness of the proposed model, two different fiber-reinforced rubber materials under uniaxial and shear testing are considered. For each kind of material, numerical simulations based on the proposed model are consistent with experimental results and provide information about the effect of the new family of invariants in the construction of the SEF.
Polyaspartamide-based nanoparticles loaded with fluticasone propionate and the in vitro evaluation towards cigarette smoke effects
2017
This paper describes the evaluation of polymeric nanoparticles (NPs) as a potential carrier for lung administration of fluticasone propionate (FP). The chosen polymeric material to produce NPs was a copolymer based on α,β-poly(N-2-hydroxyethyl)-d,l-aspartamide (PHEA) whose backbone was derivatised with different molecules, such as poly(lactic acid) (PLA) and polyethylenglycol (PEG). The chosen method to produce NPs from PHEA-PLA-PEG2000 was the method based on high-pressure homogenization and subsequent solvent evaporation by adding Pluronic F68 during the process and trehalose before lyophilisation. Obtained colloidal FP-loaded NPs showed a slightly negative surface charge and nanometric d…
Strange attractor for the renormalization flow for invariant tori of Hamiltonian systems with two generic frequencies
1999
We analyze the stability of invariant tori for Hamiltonian systems with two degrees of freedom by constructing a transformation that combines Kolmogorov-Arnold-Moser theory and renormalization-group techniques. This transformation is based on the continued fraction expansion of the frequency of the torus. We apply this transformation numerically for arbitrary frequencies that contain bounded entries in the continued fraction expansion. We give a global picture of renormalization flow for the stability of invariant tori, and we show that the properties of critical (and near critical) tori can be obtained by analyzing renormalization dynamics around a single hyperbolic strange attractor. We c…