Search results for "WES"

showing 10 items of 1585 documents

Identification of an LPS-Induced Chemo-Attractive Peptide from Ciona robusta

2020

Background: Previously published work has demonstrated that the LPS injection of Ciona robusta leads to the overexpression of a truncated form of an immune-related mRNA (C8short) by means of Ciona robusta (CR) alternative polyadenylation (APA) (CR-APA). Methods: The 3D structure of the C8short-derived Ciona robusta chemo-attractive peptide (CrCP) was evaluated by homology modeling. The biological activity of the CrCP was studied in vitro using a primary human dermal cell line (HuDe). Real-Time PCR was used to investigate the expression levels of genes involved in cell motility. NF-&kappa

In silicoPharmaceutical ScienceMotilitychemoattractive peptide03 medical and health sciencesAdapter molecule crk0302 clinical medicineWestern blotDrug DiscoverymedicineNF-kBCiona robustaPharmacology Toxicology and Pharmaceutics (miscellaneous)<i>Ciona robusta</i>lcsh:QH301-705.5030304 developmental biology0303 health sciencesmedicine.diagnostic_testChemistryfungiIn vitro3D modellingCell biologyBlotlcsh:Biology (General)Cell cultureinflammation030220 oncology & carcinogenesisSignal transductionCiona robusta; inflammation; chemoattractive peptide; NF-kB; 3D modellingMarine Drugs
researchProduct

Profile of P-glycoprotein distribution in the rat and its possible influence on the salbutamol intestinal absorption process.

2004

8 pages, 2 figures, 2 tables.--PMID: 15124220 [PubMed]

In situAbsorption (pharmacology)Maleverapamilmedicine.medical_specialtymRNAPharmaceutical ScienceWestern blotIn Vitro TechniquesIntestinal absorptionPharmacokineticsWestern blotInternal medicinemedicineAnimalsAlbuterolATP Binding Cassette Transporter Subfamily B Member 1Rats WistarP-glycoproteinmedicine.diagnostic_testbiologyintestinal absorptionintestinal secretionMolecular biologyP-glycoprotein (P-gp) expressionRatsEndocrinologyIntestinal Absorptionsalbutamolreverse transcription-polymerase chain reaction (RT-PCR)Salbutamolbiology.proteinbioavailabilityPerfusionmedicine.drugJournal of pharmaceutical sciences
researchProduct

The long‐term relationship between economic development and regional inequality: South‐West Europe, 1860–2010

2019

This paper analyses the long‐term relationship between regional inequality and economic development. Our data set includes information on national and regional per capita GDP for four countries: France, Italy, Portugal and Spain, compiled on a decadal basis for the period 1860–2010. Using parametric and semiparametric regressions, our results confirm the rise and fall of regional inequalities over time although in recent decades they are on the rise again. Finally, we identify structural change as being a significant transmission mechanism of the inverted‐U relationship. The arrival of technological shocks, beginning during the onset of industrialization, and the transition from agrarian to…

Inequalitymedia_common.quotation_subjectWelfare economics05 social sciencesGeography Planning and Development0211 other engineering and technologies021107 urban & regional planning02 engineering and technologyEnvironmental Science (miscellaneous)GeographyKuznets curve0502 economics and business050207 economicsWest europemedia_commonPapers in Regional Science
researchProduct

Effects of Fiscal Stimulus in Structural Models

2010

The paper assesses, using seven structural models used heavily by policymaking institutions, the effectiveness of temporary fiscal stimulus. Models can, more easily than empirical studies, account for differences between fiscal instruments, for differences between structural characteristics of the economy, and for monetary-fiscal policy interactions. Findings are: (i) There is substantial agreement across models on the sizes of fiscal multipliers. (ii) The sizes of spending and targeted transfers multipliers are large. (iii) Fiscal policy is most effective if it has some persistence and if monetary policy accommodates it. (iv) The perception of permanent fiscal stimulus leads to significant…

InflationWestern hemisphereStimulus (economics)media_common.quotation_subjectjel:E62Monetary policyMonetary economicsjel:E52jel:E12Fiscal policyjel:E13Economics Econometrics and Finance (all)2001 Economics Econometrics and Finance (miscellaneous)Empirical researchGeneral [Fiscal stimulus;Fiscal policy;Fiscal Multipliers Government Deficits inflation real interest rate aggregate demand Open Economy Macroeconomics International Policy Coordination and Transmission Fiscal Policies and Behavior of Economic Agents]PerceptionDynamic stochastic general equilibriumEconomicsGeneral Earth and Planetary SciencesReal interest rateGeneral Economics Econometrics and FinanceAggregate demandGeneral Environmental Sciencemedia_common
researchProduct

Understanding the Health Disaster: Research Design for the Response to the 2014 West African Ebola Outbreak

2015

International audience; The 2014 Ebola outbreak in West Africa is the largest ever in history, affecting multiple countries and to this date, the World Health Organization has registered more than 6,500 deaths attributed to Ebola. The challenges arising from this outbreak to responders worldwide do not follow the standard characterisation or response patterns of natural sudden onset vs. conflict disasters. Rather, it is a medical emergency, which is intertwined with multiple challenges in the sectors decision-making, coordination, logistics and information management. In this paper, we present our research framework, which is based on desk research and initial interviews with responders. Th…

Information managementEbola Virus DiseaseEconomic growthOperations researchDisaster researchDecision SupportOutbreakCoordination and Information SharingGeneral MedicineWorld health3. Good healthWest africaHumanitarian LogisticsWest african[SPI]Engineering Sciences [physics]GeographyConceptual frameworkField researchHealth DisasterEngineering(all)
researchProduct

L’infrastruttura scomparsa. Il nuovo suolo della stazione Alta Velocità La Sagrera a Barcellona

2017

L’enorme progetto appena completato a Barcellona per il nuovo polo ferroviario della stazione Sagrera si caratterizza soprattutto per il legame fra la nuova stazione dell’Alta Velocità (AVE) e il vasto parco lineare, progetto opera di West 8, che copre la lunga trincea un tempo determinata nel tessuto urbano dai binari preesistenti. Ricostruendo il quadro di uno dei più grandi e ambiziosi progetti di rigenerazione urbana legati all’infrastruttura ferroviaria oggi in Europa, questo articolo si concentra sulla subordinazione della stazione al parco. Non si tratta di una semplice condizione di posizione (la stazione è letteralmente sotto il parco), ma di una nuova e sempre più diffusa condizio…

Infrastructural architecturerailroad station linear park Sagrera Barcelona West 8Settore ICAR/14 - Composizione Architettonica E UrbanaArchitettura e infrastruttura Stazione ferroviaria Stazione Alta Velocità Parco lineare Sagrera Barcellona West 8
researchProduct

Uso de la infografía en la optativa “Alimentación y Dietética” del grado de Medicina

2020

[ES] Como sustitución de la clase magistral, en la sesión dedicada a tratar las características de “dietas occidentales de moda” de la asignatura optativa 34493-Alimentación y Dietética del Grado en Medicina de la Universitat de Valencia, se utilizaron infografías previamente diseñadas por los estudiantes. Con esta iniciativa se pretendía mejorar la participación del alumnado en la asignatura, además de profundizar en la materia, mejorar sus habilidades digitales y de búsqueda y síntesis de información. Esta propuesta fue bien valorada por el estudiantado, que mostró su preferencia por esta forma de trabajar frente a la clase magistral. Además, opinó que la actividad mejoraba su capacidad d…

Innovación educativaInformation searchInfografiaWestern DietInfographicsBúsqueda de informaciónSynthesisClassroom practicesEducación superiorMedicineHabilidades digitalesEnseñanza superiorDieta occidentalTecnologías y educaciónDigital skillsLibro de Actas IN-RED 2020: VI Congreso de Innovación Edicativa y Docencia en Red
researchProduct

Stratigraphical ranges of tegulated inoceramid bivalves in the type area of the Maastrichtian Stage (Belgium, the Netherlands)

2018

Abstract Recently collected material, in fine- to medium-grained biocalcarenites and in coeval flint nodules, of the tegulated inoceramid taxa Spyridoceramus tegulatus (von Hagenow, 1842) and Tenuipteria argentea (Conrad, 1858) from various members of the Gulpen Formation and the overlying Maastricht Formation allows their stratigraphical ranges to be refined. It is concluded that the ranges correspond closely to those in east-central Poland (Vistula [Wisla] River valley region), where S. tegulatus occurs in the lower Maastrichtian and lower upper Maastrichtian ( Endocostea typica , Trochoceramus radiosus and ‘ Inoceramus ’ ianjonaensis inoceramid zones, or Belemnella occidentalis and Belem…

Inoceramus010506 paleontologyBelemnitellabiologyCorrelationsRange (biology)Northwest EuropeStratigraphyPaleontology010502 geochemistry & geophysicsbiology.organism_classification01 natural sciencesCretaceousCretaceousCephalopodPaleontologyInoceramidaeStage (stratigraphy)MolluscaInoceramidaeGeologyBelemnella0105 earth and related environmental sciencesCretaceous Research
researchProduct

Rediscovery of Cerroneuroterus apenninus (Trotter, 1923) (Hymenoptera: Cynipidae: Cynipini) a valid species from Italy with description and neotype d…

2021

Neuroterus apenninus Trotter, 1923 associated with a Cerris section oak, Quercus cerris L., was rediscovered in Italy in 2017. Alessandro Trotter (1903) described a leaf gall collected on Q. cerris from the Italian Apennines; he did not obtain the gall inductor and ascribed the galls to the genus Neuroterus, based on morphological similarity with other Neuroterus galls. We have found the same gall and obtained the gall inducer. Detailed study of morphological characters of adults revealed that the species belongs to the genus Cerroneuroterus Melika &amp; Pujade-Villar, 2010. The asexual generation of Cerroneuroterus apenninus comb. n. is described for the first time, a neotype is designated…

InsectaArthropodaWaspsIdentification keyBiologyQuercusGenusCynipidaeBotanyAnimaliaGallAnimalsEcology Evolution Behavior and SystematicsTaxonomyCynipiniQuercus cerrisWestern PalaearcticBiodiversityNeuroterusbiology.organism_classificationHymenopteraPlant LeavesSettore AGR/11 - Entomologia Generale E ApplicataItalyoak gallwasp asexual generation taxonomy morphology distribution biology QuercusAnimal Science and ZoologyTaxonomy (biology)Zootaxa
researchProduct

Relationship between esterase activity and acrinathrin and methiocarb resistance in field populations of western flower thrips, Frankliniella occiden…

2006

The western flower thrips, Frankliniella occidentalis (Pergande), is a serious pest in the south-east of Spain owing to its direct feeding on crops, transmission of the tomato spotted wilt virus and its very high level of resistance to insecticides. Mechanisms of resistance were examined using field populations of F. occidentalis with different susceptibilities to acrinathrin, methiocarb (selective insecticides), endosulfan, metamidophos and deltamethrin (broad-spectrum insecticides). Esterase activity towards alpha-naphthyl acetate and p-nitrophenyl acetate in resistant strains was significantly higher than in the reference strain (MLFOM) for both model substrates. This higher activity was…

InsecticidesPesticide resistanceInsectaMethiocarbNaphtholsInsecticide ResistanceLethal Dose 50Nitrophenolschemistry.chemical_compoundBotanyPyrethrinsAnimalsEndosulfanbiologyEsterasesfood and beveragesGeneral MedicineThripidaebiology.organism_classificationWestern flower thripsHorticultureDeltamethrinchemistryMethiocarbInsect ScienceAcrinathrinPEST analysisAgronomy and Crop SciencePest management science
researchProduct