Search results for "WES"
showing 10 items of 1585 documents
Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells.
2007
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is a protective principle in the vasculature. Many cardiovascular diseases are associated with reduced NO bioactivity and eNOS uncoupling due to oxidative stress. Compounds that reverse eNOS uncoupling and increase eNOS expression are of therapeutic interest. Zizyphi Spinosi semen (ZSS) is one of the most widely used traditional Chinese herbs with protective effects on the cardiovascular system. In human umbilical vein endothelial cells (HUVEC) and HUVEC-derived EA.hy 926 cells, an extract of ZSS increased eNOS promoter activity, eNOS mRNA and protein expression, and NO production in a concentration- and time-dependent manner. Maj…
A nonsense mutation abrogates production of a functional enterotoxin A in Clostridium difficile toxinotype VIII strains of serogroups F and X.
1999
Clostridium difficile strains of toxinotype VIII from serogroups F and X are described as toxin B-positive, toxin A-negative (TcdB+ A-), although they harbour almost the entire tcdA gene. To identify the reason for the lack of TcdA detection, we analyzed catalytic and ligand domains of TcdA-1470 of the type strain of serogroup F, strain 1470. Using recombinant fragments, the C-terminal immunodominant ligand domain TcdA3-1470, spanning amino acid residues 1694-2711 (corresponding to VPI 10463 sequence), was detected in Western blots. Similar experiments using the recombinant N-terminal catalytic fragment TcdAc1-2-1470 (amino acid positions 1-544) failed. In addition, this fragment showed no …
The extrabasinal elements in Lower Pennsylvanian floras of the Maritime Provinces, Canada: Description of Adiantites, Pseudadiantites and Rhacopterid…
2021
Adiantites adiantoide s (Lindley and Hutton) Kidston, Pseudadiantites sessilis (Roehl) Gothan and Pseudadiantites rhomboideus (Ettingshausen) comb. nov. are figured and described as well as Rhacopteridium speciosum (Ettingshausen) Hirmer, as part of a revision of lower Pennsylvanian floras of Nova Scotia. These species show a foliar branching structure which is described as "pseudopinnate" as against the fully planated pinnate structure of the Palaeozoic fern and pteridosperm fronds. Their systematic affinity is unknown. A discussion is presented of the genera A diantites, Pseudadiantites, Aneimites , Palaeopteridium , and Triphyllopteris , and the problematic nature of the history of Adian…
Update of the search for charginos nearly mass-degenerate with the lightest neutralino
2000
The data collected by DELPHI in 1998 at the centre-of-mass energy of 189 GeV have been used to update the search for charginos nearly mass-degenerate with the lightest supersymmetric particle, which is assumed to be the lightest neutralino. Mass differences below \Delta M = 3 GeV/c^2 are considered. No excess of events with respect to the Standard Model expectation has been observed, and exclusions in the plane of \Delta M versus chargino mass are given. The new \Delta M independent lower limit on the mass of the chargino is 62.4 GeV/c^2 in the higgsino scenario (which includes the gaugino mass unification scenario), if all sfermions are heavier than the lightest chargino. In the approximat…
Single intermediate vector boson production in e(+)e(-) collisions at root s=183 and 189 GeV
2001
The cross sections for the production of single charged and neutral intermediate vector bosons were measured using integrated luminosities of 52 pb-1 and 154 pb-1 collected by the experiment at centre-of-mass energies of 182.6 GeV and 188.6 GeV, respectively. The cross sections for the reactions were determined in limited kinematic regions. The results found are in agreement with the Standard Model predictions for these channels. © 2001 Elsevier Science B.V.
Improved measurements of cross sections and asymmetries at the Z0 resonance
1994
During the 1992 running period of the LEP e+e- collider, the DELPHI experiment accumulated approximately 24 pb-1 of data at the Z0 peak. The decays into hadrons and charged leptons have been analysed to give values for the cross sections and leptonic forward-backward asymmetries which are significantly improved with respect to those previously published by the DELPHI collaboration. Incorporating these new data, more precise values for the Z0 resonance parameters are obtained from model-independent fits. The results are interpreted within the framework of the Standard Model, yielding for the top quark mass m(t) = 157(-48)+36(expt.)-20(+19)(Higgs) GeV, and for the effective mixing angle sin2 …
Bedrock Characterisation of Four Candidate Repository Sites in Finland As Determined by He-Gas Methods
1999
AbstractAt the end of the year 2000, one of four sites will be chosen as the final repository site in Finland. Therefore accurate and comprehensive statistics of the bedrock characteristics such as porosity [% ] and effective diffusion coefficient [m2/s ] of these sites are of importance. Altogether 115 rock samples from the four sites were measured by different He-gas methods to achieve this goal.The results obtained indicate that the average bedrock properties at these sites are quite similar. Variations among individual samples and different rock types within one repository site were larger than variations among the averaged values of the four sites. Some indication of increased microfra…
Localization of mitochondrial Hsp56 chaperonin during sea urchin development.
2001
We have previously demonstrated that Paracentrotus lividus nuclear genome encodes for the heat shock inducible chaperonin homolog Hsp 56 (1) and that the mature protein is localized in the mitochondrial matrix (2). In this paper we report that constitutive Hsp56 is maternally inherited, in fact it is present in the in unfertilized eggs, and that it has a perinuclear specific localization during cleavage. In the later stages both the constitutive and the heat shock inducible chaperonin has a specific territorial distribution. Moreover following heat shock, the Hsp56 appears in the cytoplasm and in the postmitochondrial supernatant beside the mitochondrial fraction.
How social network sites and other online intermediaries increase exposure to news
2020
Research has prominently assumed that social media and web portals that aggregate news restrict the diversity of content that users are exposed to by tailoring news diets toward the users’ preferences. In our empirical test of this argument, we apply a random-effects within–between model to two large representative datasets of individual web browsing histories. This approach allows us to better encapsulate the effects of social media and other intermediaries on news exposure. We find strong evidence that intermediaries foster more varied online news diets. The results call into question fears about the vanishing potential for incidental news exposure in digital media environments.
Benign and severe early-life seizures: a round in the first year of life
2018
Abstract Background At the onset, differentiation between abnormal non-epileptic movements, and epileptic seizures presenting in early life is difficult as is clinical diagnosis and prognostic evaluation of the various seizure disorders presenting at this age. Seizures starting in the first year of life including the neonatal period might have a favorable course, such as in infants presenting with benign familial neonatal epilepsy, febrile seizures simplex or acute symptomatic seizures. However, in some cases, the onset of seizures at birth or in the first months of life have a dramatic evolution with severe cerebral impairment. Seizure disorders starting in early life include the “epilepti…