Search results for "WIDE"
showing 10 items of 1235 documents
Benchmarking of strength models for unidirectional composites under longitudinal tension
2018
© 2018 Elsevier Ltd Several modelling approaches are available in the literature to predict longitudinal tensile failure of fibre-reinforced polymers. However, a systematic, blind and unbiased comparison between the predictions from the different models and against experimental data has never been performed. This paper presents a benchmarking exercise performed for three different models from the literature: (i) an analytical hierarchical scaling law for composite fibre bundles, (ii) direct numerical simulations of composite fibre bundles, and (iii) a multiscale finite-element simulation method. The results show that there are significant discrepancies between the predictions of the differe…
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
2013
Journal article TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10!-7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10!-8) and BRCA1 mutation carrier (P = 1.1 × 10!-5) breast cancers and altered promot…
Methodological Approach for Messages Classification on Twitter Within E-Government Area
2018
The constant growth in the numbers of Social Media users is a reality of the past few years. Companies, governments and researchers focus on extracting useful data from Social Media. One of the most important things we can extract from the messages transmitted from one user to another is the sentiment—positive, negative or neutral—regarding the subject of the conversation. There are many studies on how to classify these messages, but all of them need a huge amount of data already classified for training, data not available for Romanian language texts. We present a case study in which we use a Naive Bayes classifier trained on an English short text corpus on several thousand Romanian texts. …
Primo rinvenimento di Juniperus sabina L. sul massiccio del Pollino, Italia meridionale
1992
Viene segnalata per la prima volta la presenza di Juniperus sabina L. sul massiccio del Pollino, dove la specie è stata rinvenuta in habitat rupicolo in due stazioni ricadenti rispettivamente in territorio calabrese e lucano. Le stazioni vengono caratterizzate dal punto di vista floristico ed ecologico.
Highly Functionalized Ferrocenes
2020
International audience; Ferrocene is unique among organometallic compounds, and serves notably as a versatile platform towards the production of ligands useful to promote transition metals chemistry. A general limiting aspect of the synthesis of ferrocene derivatives is the efficient access to sophisticated highly functionalized polysubstituted ferrocenes, i. e. bearing four or more substituents replacing hydrogen atoms on the cyclopentadienyl rings. These ferrocene derivatives can bear various functional or/and structuring spectator substituents. Their preparation involves synthetic difficulties resulting from the need of multiple functionalizations coexisting altogether, and satisfying fu…
LinkedSaeima: A Linked Open Dataset of Latvia’s Parliamentary Debates
2019
This paper describes the LinkedSaeima dataset that contains structured data about Latvia’s parliamentary debates from 1993 until 2017. This information is published at http://dati.saeima.korpuss.lv as Linked Open Data. It is a part of the Corpus of Saeima (the Parliament of Latvia) released as open data for multidisciplinary research. The data model of LinkedSaeima follows the data structure of the LinkedEP dataset with a few modifications. The dataset is augmented with links to the Wikidata knowledge base that provide additional information about the speakers and named entities mentioned in the corpus.
Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae.
2014
Abstract Background Specific histone modifications play important roles in chromatin functions; i.e., activation or repression of gene transcription. This participation must occur as a dynamic process. Nevertheless, most of the histone modification maps reported to date provide only static pictures that link certain modifications with active or silenced states. This study, however, focuses on the global histone modification variation that occurs in response to the transcriptional reprogramming produced by a physiological perturbation in yeast. Results We did a genome-wide chromatin immunoprecipitation analysis for eight specific histone modifications before and after saline stress. The most…
Efficient Design of Waveguide Manifold Multiplexers Based on Low-Order EM Distributed Models
2015
In this paper, a new systematic technique to design manifold-coupled multiplexers in waveguide technology is proposed. The new technique uses generalized low-order electromagnetic (EM) distributed models, which constitute a half-way point between the fast, but imprecise, analytical models, and the more accurate, but costly, full-wave EM models. The method can be applied to contiguous and noncontiguous channel multiplexers, in both E-plane or H-plane configurations. This paper covers the complete design procedure for manifold multiplexers, starting from the required specifications and finishing with the physical dimensions. After explaining the general design technique for multiplexers with …
Functional genomics of Lactobacillus casei establishment in the gut
2014
International audience; Although the composition of the gut microbiota and its symbiotic contribution to key host physiological functions are well established, little is known as yet about the bacterial factors that account for this symbiosis. We selected Lactobacillus casei as a model microorganism to proceed to genomewide identification of the functions required for a symbiont to establish colonization in the gut. As a result of our recent development of a transposon-mutagenesis tool that overcomes the barrier that had prevented L. casei random mutagenesis, we developed a signature-tagged mutagenesis approach combining whole-genome reverse genetics using a set of tagged transposons and in…
The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging stu…
2017
Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N = 2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared …