Search results for "WL"
showing 10 items of 4149 documents
Folic Acid Deficiency Enhances Oral Contraceptive-Induced Platelet Hyperactivity
1997
Abstract In previous studies conducted in female rats and in women, oral contraceptives (OC) were found to induce a platelet hyperactivity that was related to an oxidative stress. Because cases of megaloblastic anemia have been reported to occur in women taking OC, these treatments are suspected of depleting folate stores. In the study presented herein, which was conducted in rats, we sought to determine the influence of dietary folic acid deficiency (FD) on the thrombogenicity of OC. Animals were fed for 6 weeks with either a folic acid-deficient diet (250 μg/kg folic acid) or a control diet (750 μg/kg). One-half of the animals in each group were treated with OC (ethinyl estradiol plus ly…
Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivati…
2006
Object Spinal cord injury (SCI) is a devastating clinical syndrome for which no truly efficacious therapy has yet been identified. In preclinical studies, erythropoietin (EPO) and its nonerythropoietic derivatives asialoEPO and carbamylated EPO have markedly improved functional outcome when administered after compressive SCI. However, an optimum treatment paradigm is currently unknown. Because the uninjured spinal cord expresses a high density of EPO receptor (EPOR) in the basal state, signaling through these existing receptors in advance of injury (pharmacological preconditioning) might confer neuroprotection and therefore be potentially useful in situations of anticipated damage. Methods…
Constructivism in Science Education: The Need for a Clear Line of Demarcation
2003
Some voices have recently begun to question the constructivist positions, which have been considered the most important contribution of the last decades in science education. It could be thought then, that the“constructivist consensus” might just be a new fashion that would once again lead us back to the immovable reception model of science learning. This questions, at the same time, the idea of an advance in the field of science education towards the construction of a coherent body of knowledge.
Gaming Bot Detection: A Systematic Literature Review
2018
In online games, some players employ programs (bots) that allow them to bypass game routines and effortlessly gain virtual resources. This practice leads to negative effects, such as reduced revenue for the game development companies and unfair treatment for ordinary players. Bot detection methods act as a counter measure for such players. This paper presents a systematic literature review of bot detection in online games. We mainly focus on games that allow resource accumulation for players between game sessions. For this, we summarize the existing literature, list categories of games ignored by the scientific community, review publicly available datasets, present the taxonomy of detection…
New trends in science education
1996
I intend to review the main contributions from the impressive developments made in science education research during the last decade. These developments have made the construction of a coherent body of knowledge possible allowing us to expect a significant improvement in the science teaching/learning process. I shall refer, in particular, to the new trends in science education research, both in the domain of science learning and science teacher‐training.
Facility management, outsourcing and contracting overview
2009
The discipline of facility management has basically originated from the experience of the field and most of the business models are driven from the American market. The majority of surveys agree that organizational objectives vary according to different business environments. The link between a given company and its facility management department has been studied in details with a widespread agreement on the importance of tailoring to the specific context the facility management organizational model and the approach to the relationships with suppliers. In Europe two Technical Committees of the Comite Europeen de Normalisation (CEN) are currently adding to the body of knowledge terminologies…
The Complex System Theory for the Analysis of Inter-Firm Networks: A Literature Overview and Theoretic Framework
2011
In this paper we discuss the body of knowledge known as complex system theory and its relevance to the analysis of inter-firm networks. We start by addressing the development of systems thinking. Through a literature overview, we point out the main elements for the development of systemic thought from its beginning, through its application in business sciences, to the birth of Complex Systems Theory (CST). With these initial annotations we provide an introduction to the concepts of the complex systems theory. We will underscore those aspects of CST that can be useful to analyze inter-firm networks, in order to highlight the evolutionary dynamics of the networks and to clarify the logical li…
Factors Influencing Accounting Outsourcing Practices among SMEs in Pakistan Context: Transaction Cost Economics (TCE) and Resource-Based Views (RBV) …
2014
Published version of an article from the journal:International Journal of Business and Management. Also available from the publisher:http://dx.doi.org/10.5539/ijbm.v9n7p19 The present study was conducted to identify factors that affect Pakistani manufacturing SMEs decisions to outsource management accounting practices in terms of transaction cost economics (TCE) and resource-based view (RBV). A survey of 302 SMEs was carried out using convenience sampling, a personal interview owners/managers/CFOs located in 9 major cities of Pakistan. Our multiple regression analysis revealed that the frequency of non-routine tasks, asset specificity, opportunism, trust in accountant and competition has a …
Nutrigenomics and public health
2020
Abstract Nutrigenomics (the study of the bidirectional interactions between genes and diet) is rapidly developing new bodies of knowledge that will change future research in human nutrition and public health. In fact, this new research topic is becoming essential in order to design and investigate the best dietary recommendations with the aim of preventing several diseases. In this regard, it is now recognized that dietary components can affect the phenotype by regulating gene expression. Although methylation is the widest modification mediated by diet components, recent literature has pointed out several other types of epigenetic modifications, such as regulations by noncoding RNAs and his…