Search results for "WORDS"
showing 10 items of 562 documents
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Humane Orientation as a New Cultural Dimension of the GLOBE Project: A Validation Study of the GLOBE Scale and Out-Group Humane Orientation in 25 Cou…
2013
SCHLÖSSER, Oliver; HEINTZE, Anna-Maria; AL-NAJJAR, Musaed; ARCISZEWSKI, Thomas; BESEVEGIS, Elias; BISHOP, George David; BONNES, Mirilia; CLEGG, Chris W.; DROZDA-SENKOWSKA, Ewa; GABORIT, Mauricio; GARZON, Dayra; HANSEN, Tia G. B.; HESZEN, Irena; JUHASZ, Marta; KEATING, Mary A.; MANGUNDJAYA, Wustari; MANSOR, Norma; MITCHELSON, Jacqueline K.; ORTIZ-REYNOSO, Alejandra; PANDEY, Janak; PAVAKANUN, Ubolwanna; PAVLOPOULOS, Vassilis; PEIRO, Jose M.; POTOCNIK, Kristina; RESTREPO-ESPINOSA, Maria H.; SEMMER, Norbert; TUPINAMBA, Antonio Caubi Ribeiro; VENTURA, Elizabeth R.; WHOOLERY, Matthew; ZHANG, Kan. Humane orientation as a new cultural dimension of the globe project: a validation study of the globe …
Additivity of affine designs
2020
We show that any affine block design $$\mathcal{D}=(\mathcal{P},\mathcal{B})$$ is a subset of a suitable commutative group $${\mathfrak {G}}_\mathcal{D},$$ with the property that a k-subset of $$\mathcal{P}$$ is a block of $$\mathcal{D}$$ if and only if its k elements sum up to zero. As a consequence, the group of automorphisms of any affine design $$\mathcal{D}$$ is the group of automorphisms of $${\mathfrak {G}}_\mathcal{D}$$ that leave $$\mathcal P$$ invariant. Whenever k is a prime p, $${\mathfrak {G}}_\mathcal{D}$$ is an elementary abelian p-group.
On Combinatorial Generation of Prefix Normal Words
2014
A prefix normal word is a binary word with the property that no substring has more 1s than the prefix of the same length. This class of words is important in the context of binary jumbled pattern matching. In this paper we present an efficient algorithm for exhaustively listing the prefix normal words with a fixed length. The algorithm is based on the fact that the language of prefix normal words is a bubble language, a class of binary languages with the property that, for any word w in the language, exchanging the first occurrence of 01 by 10 in w results in another word in the language. We prove that each prefix normal word is produced in O(n) amortized time, and conjecture, based on expe…
Mosaic floors of roman Villa del Casale: Principal component analysis on spectrophotometric and colorimetric data
2013
Abstract Spectrophotometric and colorimetric data obtained during a measurement campaign aimed at supporting the Roman "Villa del Casale" (Piazza Armerina, Sicily, Italy) conservation activities, are presented. Special attention was paid to the possible variation of the chromatic coordinates, possibly due to the interventions of cleaning, consolidation, and protection. Data have been analyzed by the Principal Component Analysis (PCA) statistical technique, with the attempt to investigate its role in data variability reduction and verify its effectiveness in interpreting the phenomena occurring on the mosaic surface of the Villa, through grouping the observations into homogenous clusters. Ef…
Carp’s-tongue swords - morphological, metallurgical and cultural aspects
2010
This contribution discusses the results from a study of the spatial distribution of different morphological sub-groups of carp’s-tongue swords at a European scale, relating morphological types to the metallurgial make-up of the respective pieces. From this study some surprising conclusions concerning the chronological as well as the spatial dimension of the evolution of carp’s-tongue swords emerge. We also look at the degree of variability in the deposition of these artefacts and in the composition of the assemblages in question, with considerable repercussions for our understanding of the depositional contexts of metal objects in the Atlantic Bronze Age world in general.
A NEW COMPLEXITY FUNCTION FOR WORDS BASED ON PERIODICITY
2013
Motivated by the extension of the critical factorization theorem to infinite words, we study the (local) periodicity function, i.e. the function that, for any position in a word, gives the size of the shortest square centered in that position. We prove that this function characterizes any binary word up to exchange of letters. We then introduce a new complexity function for words (the periodicity complexity) that, for any position in the word, gives the average value of the periodicity function up to that position. The new complexity function is independent from the other commonly used complexity measures as, for instance, the factor complexity. Indeed, whereas any infinite word with bound…
Geochemical constraints on basalt petrogenesis in the Strait of Sicily Rift Zone (Italy): Insights into the importance of short lengthscale mantle he…
2020
Igneous activity from the late Miocene to historic time (most recently 1891 CE) in the Strait of Sicily has created two volcanic islands (Pantelleria and Linosa) and several seamounts. These volcanoes are dominated by transitional (ol + hy-normative) to alkaline (ne-normative) basaltic lavas and scoriae; volcanic felsic rocks (peralkaline trachyte-rhyolite) crop out only on Pantelleria. Although most likely erupted through continental crust, basalts demonstrate no evidence of crustal contamination and are geochemically similar to oceanic island basalts (OIB). Despite their isotopic similarities, there are considerable compositional differences with respect to major and trace element geochem…
Study of leurocyte telomere lenght and transcription in patients in the acute phase of myocardial infarction
2011
Atherosclerosis with cardiovascular complications remains today one of the leading causes of death in developed countries. In this context, development of new biomarkers of atherosclerosis has an important place. Objectives of these biomarkers are: • to identify populations most at risk of developing cardiovascular complications, • to stratify patient groups to optimize their clinical management and therapeutic, • to reveal new therapeutic targets in the treatment of the disease. In this context, we identified three biomarkers of interest, leukocyte telomere length (LTL) and level of expression of leukocyte genes c-Fos (involved in inflammatory processes and oxidative) and OGG1 (necessary r…
Effect of endothelial cell heterogeneity on nanoparticle uptake.
2020
Endothelial cells exhibit distinct properties in morphology and functions in different organs that can be exploited for nanomedicine targeting. In this work, endothelial cells from different organs, i.e. brain, lung, liver, and kidney, were exposed to plain, carboxylated, and amino-modified silica. As expected, different protein coronas were formed on the different nanoparticle types and these changed when foetal bovine serum (FBS) or human serum were used. Uptake efficiencies differed strongly in the different endothelia, confirming that the cells retained some of their organ-specific differences. However, all endothelia showed higher uptake for the amino-modified silica in FBS, but, inter…