Search results for "WTH"
showing 10 items of 5145 documents
Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination
2015
Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…
Outlying location of logistics activities : the example of the Burgundy in France
2015
International audience; This paper contributes to the understanding of spatial location of logistics activities in an outlying region. A quantitative analysis in Burgundy (French region) underlines the important polarization of warehousing developed in a limited area during 1980–1990s intensified during 2000s. The companies that locate their warehouses in Burgundy have different strategies that could explain this outlying location. For example, the low cost of land, favorable terms of tax system and the presence of a labour pool with an important unemployed rate incentive could incentive some companies to locate their warehouses in an outlying region like the Burgundy.
Evaluation of the efficacy of a new insecticide paint against malaria vectors
2015
La malaria continúa siendo un problema de salud pública global. Se calcula que en el mundo hay 3.300 millones de personas en 97 países y territorios que corren el riesgo de padecer el paludismo, y que para 1.200 millones ese riesgo es elevado (WHO, 2014). El control de la malaria a gran escala está altamente basado en al control del vector, principalmente mediante el uso de mosquiteras tratadas con insecticidas de larga duración (LLINs), y en menor medida, el Rociamiento Residual Intradomiciliario. Todos los tratamientos recomendados de LLINs y la mayoría del Rociamiento Residual Intradomiciliario se basan en el uso de piretroides. La creciente resistencia de los vectores de malaria a los p…
The energy and identification continua of burnout and work engagement : Developmental profiles over eight years
2017
Abstract Understanding of the mutual developmental dynamics between burnout and work engagement is limited due to the lack of longitudinal studies with long follow-ups and multi-wave data. This study sought to identify subgroups of employees characterized by long-term exhaustion-vigor (energy continuum) and cynicism-dedication (identification continuum). A further important aim was to investigate differences between the identified subgroups in their experiences of progress in their personal work goals. Five-wave, eight-year follow-up data among Finnish white-collar professionals ( n = 168) were studied using Latent Profile Analysis (LPA). The analysis yielded three exhaustion-vigor subgrou…
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia
2021
Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3, which has previously been associated with aggressive cancers, and found high and subtype-specific expression of IGF2BP3 in B-cell ALL, that was associated with good outcome in high-risk patients. Results suggest that IGF2BP3 could be useful to improve stratification and prognosis of B-ALL. Abstract The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved i…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Fiscal consolidation and financial reforms
2015
We use data for a panel of 17 countries over the period 1980-2005 to investigate the impact of fiscal consolidation on the likelihood of financial reforms. We show that fiscal adjustments do not boost the implementation of financial reforms. However, tax-driven fiscal consolidation programs raise the likelihood of banking sector reforms. Moreover, we find that: (i) an increase in the degree of trade openness makes countries less likely to implement financial reforms; (ii) an increase in the interest rate spreads accelerates the path of financial reforms, especially, external capital account reforms; and (iii) an improvement in the quality of political institutions strongly enhances the prob…
Perlman syndrome: Clinical report and nine-year follow-up
2005
We present the clinical and follow-up data of a female infant with Perlman syndrome from birth to the age of 9 years. Main features of Perlman syndrome include polyhydramnios, fetal overgrowth, neonatal macrosomia, macrocephaly, dysmorphic facial features, visceromegaly, nephroblastomatosis, and a predisposition for Wilm's tumor. In our patient, the nephromegaly with nephroblastomatosis was not present at birth or during the neonatal period; it became evident in the first months of postnatal life. A Wilm's tumor was diagnosed when she was about 1 year old. Long term follow-up documents the natural history of Perlman syndrome and allows us to establish the long-term prognosis of the affected…
Market Potential and Regional Economic Growth in Spain, 1860-1930
2015
espanolEn este articulo se utilizan tecnicas parametricas y no parametricas para el analisis del impacto de los cambios registrados en el potencial de mercado de las regiones espanolas sobre su dinamica de crecimiento en el periodo 1860‐1930. El estudio del caso espanol permite analizar si la construccion de nuevas infraestructuras de transporte, asi como los cambios en la politica comercial, al afectar al potencial de mercado relativo de las regiones espanolas, acabaron por moldear sus trayectorias de crecimiento. Para la realizacion del analisis se utilizan nuevas estimaciones retrospectivas de PIB per capita de las NUTS III espanolas (provincias) y una estimacion a la Harris del potencia…
Improved innovative product strategy assessment model in market research context
2019
In the innovation economy, companies more often face the need quickly and efficiently evaluate not only their existing product and service portfolios in the context of the industry’s potential, but also evaluate theoretical concepts of innovations. There are various systems for evaluating innovation concepts and already existing products and/or services for companies that are planning to expand their business in a new industry. The innovation economy is characterized by the convergence of innovations and the most demanded products on the market with continuous market upgrades. A company which wants to grow in a new industry faces an assessment challenge between already existing, demanded pr…