Search results for "Wester"
showing 10 items of 1157 documents
Endothelin Antagonism: Effects of FP Receptor Agonists Prostaglandin F2αand Fluprostenol on Trabecular Meshwork Contractility
2006
Purpose This study analyzes additional mechanisms behind the ocular hypotensive effect of prostaglandin F (PGF) receptor (FP receptor) agonists PGF2alpha and fluprostenol (fluprostenol-isopropyl ester [travoprost]), which reduce intraocular pressure (IOP) in patients with glaucoma probably by enhancing uveoscleral flow. The trabecular meshwork (TM) is actively involved in IOP regulation through contractile mechanisms. Contractility of TM is induced by endothelin (ET)-1, a possible pathogenic factor in glaucoma. The involvement of FP receptor agonists in the ET-1 effects on TM function was studied. Methods The effects of FP receptor agonists on contractility of bovine TM (BTM) were investiga…
Tiburones de aguas profundas en el Mioceno medio de Alicante: implicaciones para la recuperación de los ecosistemas abisales mediterráneos después de…
2017
El estudio de la localidad clásica de El Chorrillo del Mioceno Medio (Serravaliense) en la Provincia de Alicante, ha permitido la recuperación de una interesante asociación de microrestos de tiburones caracterizada por al menos siete taxones (Deania calcea, ¿Isistius triangulus, ¿Squaliolus cf. schaubi, ¿Paraetmopterus sp., Pristiophorus sp., Scyliorhinus sp. y un Squaliforme indeterminado) pertenecientes a tres órdenes diferentes (Squaliformes, Pristiophoriformes y Carcharhiniformes). Asociados a estos microrestos se han identificado también macrodientes pertenecientes a Cosmopolitodus hastalis, Isurus sp., Hemipristis serra, Odontaspis sp., Carcharhinus spp. y ¿Otodus (Megaselachus) megal…
The earliest tupilakosaurid amphibian with diplospondylous vertebrae from the Late Permian of southern France
2007
5 pages; International audience; A well-preserved vertebral column from the Late Permian of Southern France (Lopingian, La Lieude Formation, Lodève Basin) is described. It is composed of diplospondylous vertebrae and is most comparable with the temnospondyl Tupilakosaurus previously known from the Early Triassic of Greenland and Russia. This new specimen therefore represents the earliest occurrence of a diplospondylous tupilakosaur, and extends the geographic range of the group to Western Europe. It is an aquatic temnospondyl that used the anguilliform undulatory mode of swimming.
The submerged syntax between Late Antiquity and the Modern Age. Sources, models, and interpretative strategies
2021
The present volume contains selected papers from the international conference on “The submerged syntax between Late Antiquity and the Modern Age. Sources, models, and interpretative strategies”, that took place in Palermo, 28-29 November 2019, hosted by the Department of Humanities at the University of Palermo. The conference was organized under the umbrella of a project of national relevance funded by the Italian Ministry of Education, University and Research, named “Parts of speech meet rhetorics: searching for syntax in the continuity between the Middle Ages and the Modern Age” (PRIN 20172F2FEZ, March 2017).
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development
2014
Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essential in the embryo proper. Loss of LRP1 leads to lethal vascular defects with lack of proper investment with mural cells of both large and small vessels. We further demonstrate that LRP1 modulates Gi-dependent sphingosine-1-phosphate (S1P) signaling and integrates S1P and PDGF-BB signaling pathways, which are both crucial for mural cell recruitment, via its intracellular domain. Loss of LRP1 leads to a lack of S1P-dependent inhibition of RAC1 and loss of constraint of PDGF-BB-induced cell migra…
Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids
2021
Abstract Background Irritable bowel syndrome (IBS) is a functional bowel disorder, in which recurrent abdominal pain is associated with defecation or a change in bowel habits. STW 5-II is a combination of six medicinal herbs with a clinically proven efficacy in managing IBS. Aim This study aims to establish an in vitro IBS model using mouse intestinal organoids and to explore the anti-inflammatory and tight junction protective activities of the multi-herbal preparation STW 5-II. Methods Intestinal organoids were cultured in 1:1 Matrigel™ and medium domes. Inflammation and tight junction disruption were induced by a cocktail of cytokines (TNFα, IFNγ, IL-1β, IL-6) and bacterial proteins (LPS,…
Comparison of outer membrane protein profiles of Vibrio vulnificus biotypes 1 and 2.
1993
The outer membrane proteins of 17 Vibrio vulnificus biotype 2 strains from Japanese and European eels, and 12 biotype 1 strains from clinical and environmental sources have been compared. The overall profile in both biotypes was similar, and a major protein band of molecular mass 36 kDa was detected in the majority of the strains. Differences in the minor bands allowed differentiation of strains from different origins, suggesting that outer membrane protein profiles could be useful as epidemiological markers in the species V. vulnificus. Immunoblotting with antisera to whole cells of selected strains of biotypes 1 and 2 showed a strong antigenic response to outer membrane proteins 66, 60, 4…
C4 Alpha-Chain Reference Typing Report
1990
Previously it was shown that C4A and C4B alpha-chains after separation on SDS-PAGE can provide valuable information on presence and absence, as well as the number of C4A and C4B genes expressed in an individual. All samples submitted for C4 reference typing were also subjected to C4 alpha-chain separation; the results were included in the Final C4 Reference Typing List [Complement Inflamm 1990;7:193-212]. In addition, in selected cases with assumed 'reversed antigenicity', Western blots of C4 alpha-chains with monoclonal anti-C4A and B antibodies were obtained. As a result, subtypic differences of C4B allotypes were detected by the comparison of monoclonal antibodies 1217 and 1228.
Embryonic neural cell adhesion molecules on human natural killer cells
1989
The neural cell adhesion molecules (NCAM) are surface glycoproteins that were first described in brain tissue. NCAM mediate adhesion in a variety of cell-cell interactions. In the present study we show that the so-called "embryonic" NCAM, i.e., the highly polysialylated forms of these proteins, are expressed on natural killer cells and some CD3+ cells in man. Homotypic binding of NCAM, believed to be of importance for cell-cell adhesion in neural tissues, appears not to be essential for NK cell-mediated killing. Yet, NCAM might be involved in NK cell migration, homing or related functions.
Peritoneal Cavity is a Route for Gut-Derived Microbial Signals to Promote Autoimmunity in Non-Obese Diabetic Mice
2015
Macrophages play a crucial role in innate immune reactions, and peritoneal macrophages (PMs) guard the sterility of this compartment mainly against microbial threat from the gut. Type 1 diabetes (T1D) is an autoimmune disease in which gut microbiota and gut immune system appear to contribute to disease pathogenesis. We have recently reported elevated free radical production and increased permeability of gut epithelium in non-obese diabetic (NOD) mice. Impaired barrier function could lead to bacterial leakage to the peritoneal cavity. To explore the consequences of impaired gut barrier function on extra-intestinal immune regulation, we characterized peritoneal lavage cells from young newly w…