Search results for "YV"

Sumatriptan Succinate Transdermal Delivery Systems for The Treatment of Migraine

2007

We have successfully obtained sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propylenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of sumatriptan succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically …

Influence of high power ultrasound on physical-chemical properties of polypropylene films aimed for food packaging: barrier and contact angle features

2017

Investigation was focused on the impact of high power ultrasound (HPUS), also called thermosonication, on the oxygen permeation properties (permeability, solubility and diffusion coefficients) of barrier films aimed for food packaging. For this purpose, biaxially oriented polypropylene (BOPP) coated with acrylic/polyvinylidene chloride (BOPPAcPVDC) and biaxially oriented coextruded polypropylene (BOPPcoex) were used. The physical–chemical profile of the samples was determined using goniometry. There is a significant impact only of extreme HPUS conditions (the longest time and the highest amplitude) on the permeability, solubility and diffusion coefficients of oxygen through the BOPP films. …

014: Underuse of recommended secondary preventive therapies in current routine clinical practice

2013

Aims Recommendations on the use of antithrombotic agents, antihypertensive drugs and statin for secondary prevention of coronary artery (CAD), ischemic cerebrovacular (CVD), and peripheral arterial (PAD) diseases are now well established. However, there may be a gap between clinical practice and evidence-based guidelines. We aimed to investigate the premorbid use of secondary prevention medications in patients with recurrent cardiovascular events. Methods and results We prospectively recorded all patients with CVD and CAD in Dijon, France from 2006 to 2010. Data about medical history and prior use of treatments were collected. Mutivariate analyses were performed to identify predictors of th…

SAXS investigation on aggregation phenomena in supercritical CO2.

2004

Synchrotron Small-Angle X-Ray scattering (SAXS) measurements on aggregate formation of a Polyvinyl acetate- b-Perfluoro octyl acrylate (PVAc- b-PFOA) block copolymer in supercritical CO(2) are here reported. Experiments were carried out for a series of different thermodynamic conditions, changing the solvent density by profiling both the pressure at constant temperature and the temperature at constant pressure. This block copolymer and in general fluorocarbon-hydrocarbon di-blocks form aggregates depending on the value of CO(2) density. A sharp transition between monomers dissolved as random coils and micelles characterized by a solvophilic shell and a solvophobic core occurs when the CO(2)…

Polyvinylpolypyrrolidone‐Stabilized Copper Nanoparticles as an Efficient and Recyclable Heterogeneous Catalyst for the Click of 1,2,3‐Triazoles in Wa…

2019

Depopulation in the Baltic states

2011

Šiame straispnyje nagrinėjami pagrindiniai Baltijos šalyse vykstančių demografinių procesų bruožai. Atkūrus nepriklausomybę Estijoje, Latvijoje ir Lietuvoje išryškėjo gyventojų skaičiaus mažėjimo tendencija, kurią nulėmė neigiama natūrali gyventojų kaita ir neigiama neto tarptautinė migracija (išvykusiųjų skaičius viršija atvykusiųjų skaičių). Kartų kaitos neužtikrinantis gimstamumo lygis, santykinai aukštas mirtingumo lygis (ypač vyrų), intensyvi emigracija ir gyventojų senėjimas stebimi visose Baltijos šalyse. Šios nepalankios tendencijos ypač pasireiškė šalims įstojus į Europos Sąjungą 2004 m. Nuo 1990 m. Latvija ir Lietuva pasižymi vienais iš didžiausių depopuliacijos tempų Europoje. De…

Mutagenesis scanning uncovers evolutionary constraints on tobacco etch Potyvirus membrane-associated 6K2 protein

2019

RNA virus high mutation rate is a double-edged sword. At the one side, most mutations jeopardize proteins functions; at the other side, mutations are needed to fuel adaptation. The relevant question then is the ratio between beneficial and deleterious mutations. To evaluate this ratio, we created a mutant library of the 6K2 gene of tobacco etch potyvirus that contains every possible single-nucleotide substitution. 6K2 protein anchors the virus replication complex to the network of endoplasmic reticulum membranes. The library was inoculated into the natural host Nicotiana tabacum, allowing competition among all these mutants and selection of those that are potentially viable. We identified 1…

Intra-specific variability and biological relevance of P3N-PIPO protein length in potyviruses

2013

Background:Pipo was recently described as a new ORF encoded within the genome of the Potyviridae family members (PNAS 105:5897-5902, 2008). It is embedded within the P3 cistron and is translated in the +2 reading frame relative to the potyviral long ORF as the P3N-PIPO fusion protein. In this work, we first collected pipo nucleotide sequences available for different isolates of 48 Potyvirus species. Second, to determine the biological implications of variation in pipo length, we measured infectivity, viral accumulation, cell-to-cell and systemic movements for two Turnip mosaic virus (TuMV) variants with pipo alleles of different length in three different susceptible host species, and tested…

Metamorphoses of Shamed Bodies : Sexual Violence in Euripides’s Helen

2021

In this paper I explore the connections between shame and embodiment in Euripides’s play Helen. The paper focuses on the play’s underlying theme of sexual violence and rape, and on the descriptions of metamorphoses that the mythological female victims often undergo in the face of rape. In my analysis on shame and embodiment I apply two insights from Giorgio Agamben’s analysis of the phenomenon of victim shame in The Remnants of Auschwitz. These are, first, the definition according to which shame is “to be consigned to what cannot be assumed”—that is, to be consigned to one’s self, being and physical body—and second, the claim that in shame one is affected by one’s own (bodily) passivity. Bu…

Does mindfulness-, acceptance-, and value-based intervention alleviate burnout? : A person-centered approach

2019

This study investigated individual differences in changes in burnout symptoms during a brief mindfulness-, acceptance-, and value-based intervention. It also studied whether the changes in burnout were simultaneous with the changes in mindfulness skills. The role of practices and learning experiences in these changes were investigated. The participants were employees of various occupations (n = 105, 80% women, Mage = 48 years). Latent profile analysis was used to investigate the associations between burnout and mindfulness skills during the intervention and a 4-month follow-up period. Six distinct profiles were found that differed in levels and changes of both burnout and mindfulness skills…